Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation

Knockdown of SF3B1 inhibits cell proliferation, invasion and migration triggering apoptosis in breast cancer via aberrant splicing

(2020) Ling Zhang et al.   Breast Cancer

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

(2020) Alina-Andreea Zimta et al.   Frontiers in Oncology

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

(2019) Qianjing Zhang et al.   Artificial Cells Nanomedicine and Biotechnology

RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation

(2019) Kaikai Ding et al.   ONCOGENE

Spliceosome Component SF3B1 as Novel Prognostic Biomarker and Therapeutic Target for Prostate Cancer

(2019) Juan M. Jiménez-Vacas et al.   Translational Research

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

(2019) W. Brian Dalton et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

(2018) Andrea Pellagatti et al.   BLOOD

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

(2018) Michael Seiler et al.   Cell Reports

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B

(2018) Xuexia Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Genetics of Endometrial Carcinoma

(2018) Daphne W. Bell et al.   Annual Review of Pathology-Mechanisms of Disease

A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer

(2017) Jing Gong et al.   Cell Reports

Alternative splicing and cell survival: from tissue homeostasis to disease

(2016) Maria Paola Paronetto et al.   CELL DEATH AND DIFFERENTIATION

Genetic alterations in endometrial cancer by targeted next-generation sequencing

(2016) Ya-Sian Chang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

(2016) Tassa Saldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

(2016) Constantin Cretu et al.   MOLECULAR CELL

Splicing-factor alterations in cancers

(2016) Olga Anczuków et al.   RNA

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation

(2016) Yi Huang et al.   Oncotarget

Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

(2016) Nancy Martínez-Montiel et al.   Biomed Research International

Disease-associated mutation inSRSF2misregulates splicing by altering RNA-binding affinities

(2015) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USA Endometrial Cancer Projections to 2030: should we be concerned?

(2014) M Aamir Sheikh et al.   Future Oncology

mRNA stability in the nucleus

(2014) Han Liu et al.   Journal of Zhejiang University-SCIENCE B

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

(2014) H Dolatshad et al.   LEUKEMIA

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events

(2014) Angela N. Brooks et al.   PLoS One

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition

(2013) H. Cheng et al.   CANCER RESEARCH

High antitumor activity of pladienolide B and its derivative in gastric cancer

(2013) Momoko Sato et al.   CANCER SCIENCE

Coherence between Cellular Responses andin VitroSplicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs

(2013) Kerstin A. Effenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

(2012) F. Thol et al.   BLOOD

Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

(2012) V Visconte et al.   LEUKEMIA

Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK

(2012) M. R. Fernandez et al.   MOLECULAR AND CELLULAR BIOLOGY

Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis

(2011) Xiu-ying Xiao et al.   CANCER LETTERS

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

(2010) Jipei Liao et al.   Molecular Cancer

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

(2009) Michele K. Dougherty et al.   MOLECULAR CELL

Conditional Loss of Uterine Pten Unfailingly and Rapidly Induces Endometrial Cancer in Mice

(2008) T. Daikoku et al.   CANCER RESEARCH

Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines

(2008) M. S. Pino et al.   CLINICAL CANCER RESEARCH