Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis

Organocatalytic Asymmetric Synthesis of Cyclic Compounds Bearing a Trifluoromethylated Stereogenic Center: Recent Developments

(2019) Xiang-Hong He et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

(2019) Takuya Ishii et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Construction of Quaternary All-Carbon Centers via Copper-Catalyzed Arylation of Tertiary Carbon-Centered Radicals

(2019) Lianqian Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene Catalyzed Radical Coupling of Aldehydes with Redox-Active Esters

(2019) Runjiang Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Vicinal Alkylacylation of Alkenes

(2019) Takuya Ishii et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Nitroarenes as Enantioselective Single-Electron-Transfer Oxidants for Carbene-Catalyzed Radical Reactions

(2019) Hongling Wang et al.   ORGANIC LETTERS

A Copper Catalyst with a Cinchona-Alkaloid-Based Sulfonamide Ligand for Asymmetric Radical Oxytrifluoromethylation of Alkenyl Oximes

(2018) Xi-Tao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Construction of Halogenated Quaternary Carbon Centers by Brønsted Base Catalyzed [4+2] Cycloaddition of α-Haloaldehydes

(2018) Qiang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An asymmetric tertiary carbon center with a tetrafluoroethylene (–CF 2 CF 2 –) fragment: Novel construction method and application in a chiral liquid crystalline molecule

(2018) Keigo Yamashika et al.   JOURNAL OF FLUORINE CHEMISTRY

Diastereo- and Enantioselective Synthesis of Spirooxindoles with Contiguous Tetrasubstituted Stereocenters via Catalytic Coupling of Two Tertiary Radicals

(2018) Zhi-Yong Song et al.   JOURNAL OF ORGANIC CHEMISTRY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Intermolecular selective carboacylation of alkenes via nickel-catalyzed reductive radical relay

(2018) Xian Zhao et al.   Nature Communications

Design, synthesis and anticonvulsant evaluation of fluorinated benzyl amino enaminones

(2018) John Apraku et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective Catalytic Formation of Cross-Tetramers from Tetrafluoroethylene, Ethylene, Alkynes, and Aldehydes via Nickelacycles as Key Reaction Intermediates

(2018) Takuya Kawashima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What Are the Radical Intermediates in Oxidative N-Heterocyclic Carbene Organocatalysis?

(2018) Vianney Regnier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)2Zn: Synthesis and Antiproliferative Evaluation

(2017) Jing Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbene-Catalyzed Reductive Coupling of Nitrobenzyl Bromide and Nitroalkene via the Single-Electron-Transfer (SET) Process and Formal 1,4-Addition

(2017) Yuhuang Wang et al.   ORGANIC LETTERS

N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate

(2017) Xiang-Yu Chen et al.   Chemical Science

The dual role of thiourea in the thiotrifluoromethylation of alkenes

(2017) Paolo Ricci et al.   Chemical Science

On the design of complex drug candidate syntheses in the pharmaceutical industry

(2017) Martin D. Eastgate et al.   Nature Reviews Chemistry

N-Heterocyclic Carbene Catalyzed γ-Dihalomethylenation of Enals by Single-Electron Transfer

(2016) Wen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?

(2016) Daniel J. Foley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings

(2016) Zhong-Liang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes via Radical Process

(2016) Fei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radicals: Reactive Intermediates with Translational Potential

(2016) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbene-catalysed reductive coupling of nitrobenzyl bromides and activated ketones or imines via single-electron-transfer process

(2016) Bao-Sheng Li et al.   Nature Communications

Academia–Industry Symbiosis in Organic Chemistry

(2015) Quentin Michaudel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Advances in Transition-Metal-Mediated Di-and Monofluoroalkylations

(2015) Chuanfa Ni et al.   ACTA CHIMICA SINICA

Catalysis of Radical Reactions: A Radical Chemistry Perspective

(2015) Armido Studer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in the One-Step Synthesis of Distally Fluorinated Ketones

(2015) Yuwen Zeng et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β-Hydroxylation of Enals

(2015) Yuexia Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Formation of Fluorine-Containing Ketones via the Selective Cross-Trimerization Reaction of Tetrafluoroethylene, Ethylene, and Aldehydes

(2015) Masato Ohashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidatively Initiated NHC-Catalyzed Enantioselective Synthesis of 3,4-Disubstituted Cyclopentanones from Enals

(2015) Nicholas A. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NHC-catalysed benzoin condensation – is it all down to the Breslow intermediate?

(2015) Julia Rehbein et al.   Chemical Science

Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups

(2014) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective N-Heterocyclic Carbene-Catalyzed β-Hydroxylation of Enals Using Nitroarenes: An Atom Transfer Reaction That Proceeds via Single Electron Transfer

(2014) Nicholas A. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

N-Heterocyclic Carbene Organocatalytic Reductive β,β-Coupling Reactions of Nitroalkenes via Radical Intermediates

(2014) Yu Du et al.   ORGANIC LETTERS

Copper-Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols

(2013) Zhi-Min Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Trifluoromethylation-Initiated Radical 1,2-Aryl Migration in α,α-Diaryl Allylic Alcohols

(2013) Xiaowu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines

(2013) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)–N Bond Formation of Conjugated Tosyl Amides

(2013) Wangqing Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light-Mediated Atom Transfer Radical Addition via Oxidative and Reductive Quenching of Photocatalysts

(2012) Carl-Johan Wallentin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Oxytrifluoromethylation of Unactivated Alkenes

(2012) Rong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles

(2010) Bo Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

Synthesis and Evaluation of a Novel Indoledione Class of Long Chain Fatty Acid Elongase 6 (ELOVL6) Inhibitors

(2009) Toshiyuki Takahashi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesizing our future

(2009) Ryoji Noyori   Nature Chemistry

Biomimetic Carbene-Catalyzed Oxidations of Aldehydes Using TEMPO

(2008) Joyram Guin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents

(2008) Olugbeminiyi O. Fadeyi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-Catalyzed C-Allylation of Benzoins and an NHC-Catalyzed Three Component Coupling Derived Thereof: Compatibility of NHC- and Pd-Catalysts

(2008) Raphaël Lebeuf et al.   ORGANIC LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS