Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

Cellular Senescence and Radiation-induced Pulmonary Fibrosis

(2019) Yonghan He et al.   Translational Research

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

USP7: Structure, substrate specificity, and inhibition

(2019) Alexandra Pozhidaeva et al.   DNA REPAIR

USP7: Target Validation and Drug Discovery for Cancer Therapy

(2018) Jin Zhou et al.   Medicinal Chemistry

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

(2017) Veronica Tisato et al.   Journal of Hematology & Oncology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

(2017) Giovanna Carrà et al.   Oncotarget

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells

(2016) Gibok Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple facets of p53 in senescence induction and maintenance

(2016) Yoshikazu Johmura et al.   CANCER SCIENCE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

(2016) Omid Tavana et al.   NATURE MEDICINE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

(2016) Yoshikazu Johmura et al.   Nature Communications

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Regulation of p53 during senescence in normal human keratinocytes

(2015) Reuben H. Kim et al.   AGING CELL

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53

(2015) Kristina Kirschner et al.   PLoS Genetics

Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence

(2014) R. R. Nair et al.   JOURNAL OF CELL SCIENCE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

(2013) Y-H Fan et al.   Cell Death & Disease

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

CHIP-dependent p53 regulation occurs specifically during cellular senescence

(2010) Christina Sisoula et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Transcription-independent p53 apoptosis: an alternative route to death

(2009) Daniel Speidel   TRENDS IN CELL BIOLOGY