Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma

(2019) Julieann C. Lee et al.   ACTA NEUROPATHOLOGICA

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

(2019) Patrick Sin-Chan et al.   CANCER CELL

MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes

(2018) Youwei Zhu et al.   CANCER LETTERS

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

(2018) Matija Snuderl et al.   Nature Communications

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children’s Oncology Group Randomized ACNS0332 Trial

(2018) Eugene I. Hwang et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma: From Myth to Molecular

(2017) Vijay Ramaswamy et al.   JOURNAL OF CLINICAL ONCOLOGY

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Pineoblastoma—The Experience at St. Jude Children's Research Hospital

(2017) Kara A. Parikh et al.   NEUROSURGERY

Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms’ tumor: a meta-analysis

(2017) Zhenyu Pan et al.   Oncotarget

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

(2016) Jonathon Torchia et al.   CANCER CELL

Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data

(2016) Martin Mynarek et al.   NEURO-ONCOLOGY

Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

(2016) Hsin-Yi Chen et al.   Frontiers in Oncology

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

SIFT missense predictions for genomes

(2015) Robert Vaser et al.   Nature Protocols

Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?

(2015) Vijay Ramaswamy et al.   NEURO-ONCOLOGY

Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Children's Oncology Group

(2015) Regina I. Jakacki et al.   PEDIATRIC BLOOD & CANCER

Germ-line and somatic DICER1 mutations in pineoblastoma

(2014) Leanne de Kock et al.   ACTA NEUROPATHOLOGICA

MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State

(2014) Yulin Li et al.   CANCER CELL

Trilateral retinoblastoma: a systematic review and meta-analysis

(2014) Marcus C de Jong et al.   LANCET ONCOLOGY

Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences

(2014) T J Pugh et al.   ONCOGENE

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

(2014) Dinesh Rakheja et al.   Nature Communications

Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

(2014) Giovana T. Torrezan et al.   Nature Communications

Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-Year, Single-Institution Retrospective Review

(2014) Benjamin Farnia et al.   World Neurosurgery

Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

(2014) Jian An et al.   Cell Reports

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

(2013) Peter Canning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-106a Represses the Rb Tumor Suppressor p130 to Regulate Cellular Proliferation and Differentiation in High-Grade Serous Ovarian Carcinoma

(2013) Z. Liu et al.   MOLECULAR CANCER RESEARCH

A TARBP2-Dependent miRNA Expression Profile Underlies Cancer Stem Cell Properties and Provides Candidate Therapeutic Reagents in Ewing Sarcoma

(2012) Claudio De Vito et al.   CANCER CELL

GermlineDICER1mutation and associated loss of heterozygosity in a pineoblastoma: Figure 1

(2012) Nelly Sabbaghian et al.   JOURNAL OF MEDICAL GENETICS

Cancer-associated somaticDICER1hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage

(2012) MS Anglesio et al.   JOURNAL OF PATHOLOGY

Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation

(2012) David Nittner et al.   NATURE CELL BIOLOGY

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Treatment of young children with CNS-primitive neuroectodermal tumors/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy

(2012) Carsten Friedrich et al.   NEURO-ONCOLOGY

In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs

(2012) A. M. Gurtan et al.   RNA

miR-17 92 cooperates with RB pathway mutations to promote retinoblastoma

(2011) K. Conkrite et al.   GENES & DEVELOPMENT

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma

(2011) S. Miller et al.   NEURO-ONCOLOGY

Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study

(2011) M. Fèvre-Montange et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

(2011) Alireza Heravi-Moussavi et al.   NEW ENGLAND JOURNAL OF MEDICINE

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

High incidence of allelic loss at 16q12.2 region spanning RB2/p130 gene in retinoblastoma

(2010) Kadam Priya et al.   CANCER BIOLOGY & THERAPY

Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer

(2010) Pilar Garre et al.   NATURE GENETICS

p18Ink4c and p53 Act as Tumor Suppressors in Cyclin D1-Driven Primitive Neuroectodermal Tumor

(2009) R. Saab et al.   CANCER RESEARCH

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy

(2008) Stephen W. Gilheeney et al.   JOURNAL OF NEURO-ONCOLOGY

A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET

(2008) Murali Chintagumpala et al.   NEURO-ONCOLOGY