Article
Obstetrics & Gynecology
Berna Aslan Cetin, Pelin Ocal, Tulay Irez, Ezel Uslu, Kubra Irmak, Suat Karatas
Summary: The study found a correlation between sialic acid levels in follicular fluid and oocyte quality during in vitro fertilization (IVF), but not with clinical parameters. Sialic acid levels in the follicular fluid may play a role in normal oocyte maturation or act as a compensatory mechanism against reactive oxygen species during the maturation process.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ziyu Guo, Jihong Yang, Guangping Yang, Ting Feng, Xinyue Zhang, Yao Chen, Ruizhi Feng, Yun Qian
Summary: The study found that higher levels of NAM in large follicles are associated with larger follicle development and higher rates of oocyte maturation and fertilization. Adding 5mM NAM during in vitro maturation process can improve mice oocyte quality and reduce damage caused by oxidative stress.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Cem Demirel, Firat Tulek, Hale Goksever Celik, Ersan Donmez, Gulsum Tuysuz, Bilgi Gokcan
Summary: There is currently no evidence to suggest that SARS-CoV-2 can be transmitted sexually or through IVF procedures. Additionally, there have been no reports of viral RNA presence in follicular fluid of SARS-CoV-2-positive women, indicating that the suspension of IVF treatments during the pandemic may not be directly related to virus transmission concerns.
REPRODUCTIVE SCIENCES
(2021)
Article
Genetics & Heredity
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Syeda Qurat-ul-Ain Zahra, Yousaf Latif Khan, Zahira Hassan, Nilgun Ozturk Turhan, Hikmet Hakan Aydin
Summary: The study found that patients with low melatonin levels in follicular fluid had significantly higher oxidative stress markers, cfDNA levels, and lower relative expression of certain miRNAs compared to other groups. These patients also had lower fertilization rates and fewer high-quality day 3 embryos.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Patricia Cosme, Ana B. Rodriguez, Maria Garrido, Javier Espino
Summary: Infertility is a growing global public health concern that has socio-psychological implications for couples. Advances in reproductive medicine have led to successful treatments like assisted reproductive techniques (ART), but the search for new therapeutic tools to improve success rates is ongoing. Recent research has focused on the antioxidant properties of pineal indolamine melatonin and its role in reproductive physiology, suggesting it may be a promising agent to counteract the negative effects of oxidative stress in fertility treatments. This narrative review aims to summarize the current state of research on melatonin's importance in reproductive physiology and evaluate its potential use in ART to improve fertility success rates.
Article
Reproductive Biology
Hao Tian, Qi Qi, Fengxiang Yan, Chunxin Wang, Fujun Hou, Weimin Ren, Li Zhang, Jian Hou
Summary: Supplementation of prepubertal oocytes with sericin and FLI in IVM medium significantly improved the blastocyst development rate, suggesting the potential for enhancing the developmental competence of oocytes in juvenile in vitro embryo transfer technology. These findings may contribute to the advancement of assisted reproductive technologies in relevant fields.
Article
Biochemistry & Molecular Biology
Di Zhang, Jia Lv, Rongxin Tang, Ying Feng, Yongfeng Zhao, Xiaoyang Fei, Richeng Chian, Qigui Xie
Summary: The study investigated exosomal microRNAs in human ovarian follicular fluid to explore their potential association with oocyte quality. Analysis revealed that several exosomal miRNAs were critical for maintaining oocyte quality, suggesting they may be potential biomarkers for evaluating oocyte quality, which is important in clinical settings.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Xinyang Zhao, Xu Zhang, Shanshan Wu, Jichun Tan
Summary: The duration of ovarian stimulation has a significant impact on IVF outcomes. The length of the menstrual cycle can be used to predict ovarian response and the duration of ovarian stimulation. There is a correlation between the duration of ovarian stimulation and the number of oocytes, fertilization rate, and high-quality blastocyst formation rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Jingyue Chen, Yilong Miao, Qian Gao, Zhaokang Cui, Bo Xiong
Summary: The study reveals that exposure to PFOS affects the quality of oocytes by disrupting meiotic competency, cytoskeleton assembly, and mitochondrial function, leading to oxidative stress-induced apoptosis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Euihyun Kim, Kihae Ra, Myung-Shin Lee, Geon A. Kim
Summary: Exosomes derived from porcine follicular fluid can improve the morphology and functionality of pig oocytes when added to the maturation medium. Therefore, it is suggested to use FF-derived exosomes in controlled experiments in embryology to enhance the reliability of experimental data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jiaxin Zhang, Xiaofei Ge, Zhiqin Bu
Summary: This study aimed to investigate whether the duration of late-follicular elevated progesterone (LFEP) affected pregnancy outcomes in IVF patients treated with pituitary downregulation protocols. The results showed that patients with a LFEP duration of 2 days had the lowest clinical pregnancy rate, regardless of the LFEP definition. However, after adjusting for confounders, the duration of LFEP was not significantly associated with the clinical pregnancy rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Anke Bullach, Tom Trapphoff, Sebastian Zuehlke, Michael Spiteller, Stefan Dieterle
Summary: This study found that a variety of endocrine-disrupting chemicals were present in human follicular fluid, with nonylphenol and Mirex being the most concentrated. These chemicals led to significantly reduced maturation and fertilization rates, but did not have a significant impact on the clinical pregnancy rate. The source of clothing and textiles may affect the accumulation of these chemicals in follicular fluid.
REPRODUCTIVE SCIENCES
(2021)
Article
Reproductive Biology
Juan Carlos Gutierrez-Anez, Andrea Lucas-Hahn, Klaus-Gerd Hadeler, Patrick Aldag, Heiner Niemann
Summary: The study found that adding melatonin during in vitro culture can improve cumulus-oocyte competence and embryo development in prepubertal and adult dairy cattle, enhancing embryo quality.
Article
Multidisciplinary Sciences
Safiyya Faruk Usman, Ibraheem Rais Shuaibu, Korede Durojaiye, Nubwa Medugu, Kenneth Chukwuemeka Iregbu
Summary: The study found that the presence of microorganisms in follicular fluid did not negatively impact fertilization and pregnancy rates in women undergoing IVF-ET treatment cycles.
Article
Immunology
Yue-Rong Wu, Yong-Hong Dong, Chen-Jian Liu, Xiao-Dan Tang, Ning-Nan Zhang, Jie Shen, Ze Wu, Xiao-Ran Li, Jing-Yi Shao
Summary: This study investigated the microbial composition of follicular fluid in infertile patients and its impact on infertility. The results suggested that Lactobacillus could have a positive effect on female pregnancy, while other microbes might have a negative impact. Therefore, this study provided a theoretical basis for the future microbiological treatment of female infertility.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Cell Biology
Roberto Pariente, Ignacio Bejarano, Ana Beatriz Rodriguez, Jose Antonio Pariente, Javier Espino
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Maria Patron, Veronica Granatiero, Javier Espino, Rosario Rizzuto, Diego De Stefani
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Biochemistry & Molecular Biology
Elena Fernandez-Delgado, Felipe de la Cruz-Martinez, Carmen Galan, Lourdes Franco, Javier Espino, Emilio Vinuelas-Zahinos, Francisco Luna-Giles, Ignacio Bejarano
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Nutrition & Dietetics
Ivan Cruz-Chamorro, Nuria Alvarez-Sanchez, Guillermo Santos-Sanchez, Justo Pedroche, Maria-Soledad Fernandez-Pachon, Francisco Millan, Maria Carmen Millan-Linares, Patricia Judith Lardone, Ignacio Bejarano, Juan Miguel Guerrero, Antonio Carrillo-Vico
Article
Multidisciplinary Sciences
Javier Espino, Elena Fernandez-Delgado, Samuel Estirado, Felipe de la Cruz-Martinez, Sergio Villa-Carballar, Emilio Vinuelas-Zahinos, Francisco Luna-Giles, Jose A. Pariente
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Patricia Cosme, Ana B. Rodriguez, Javier Espino, Maria Garrido
Article
Chemistry, Medicinal
Silvia Gutierrez-Tarrino, Javier Espino, Francisco Luna-Giles, Ana B. Rodriguez, Jose A. Pariente, Emilio Vinuelas-Zahinos
Summary: Research on anticancer coordination complexes has led to the development of important drugs like cisplatin, carboplatin, and oxaliplatin, but with high toxicity and side effects. New types of platinum and palladium complexes have emerged as potential anticancer drugs, with Pt(II) complexes showing strong cytotoxicity against various tumor cell lines, while Pd(II) complexes exhibit weaker antitumor effects.
Article
Biochemistry & Molecular Biology
Elena Fernandez-Delgado, Samuel Estirado, Javier Espino, Emilio Vinuelas-Zahinos, Francisco Luna-Giles, Ana B. Rodriguez Moratinos, Jose A. Pariente
Summary: One of the commonly used strategies for drug development is the coordination of bioactive ligands to transition metals. In this study, four Pt(II) complexes were synthesized and characterized, and their anticancer abilities were investigated in different cancer cell lines. The results showed that modulating the lipophilicity of the ligands can help improve the cytotoxic effect of the metal complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Guillermo Santos-Sanchez, Eduardo Ponce-Espana, Juan Carlos Lopez, Nuria Alvarez-Sanchez, Ana Isabel Alvarez-Lopez, Justo Pedroche, Francisco Millan, Maria Carmen Millan-Linares, Patricia Judith Lardone, Ignacio Bejarano, Ivan Cruz-Chamorro, Antonio Carrillo-Vico
Summary: Anxiety is a prevalent psychiatric disorder worldwide, causing economic burden. Commercial anxiolytic treatments have limitations and high costs, leading to a search for natural and safer alternatives. This study found that lupin protein hydrolysate (LPH) has anxiolytic effects and could potentially be used in nutritional therapies for anxiety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samuel Estirado, Elena Fernandez-Delgado, Emilio Vinuelas-Zahinos, Francisco Luna-Giles, Ana B. Rodriguez, Jose A. Pariente, Javier Espino
Summary: This study evaluated the antitumoral potential of PtDPhPzTn against TNBC cells, showing enhanced cytotoxicity compared to cisplatin and PtPzTn, inducing apoptosis, causing S phase arrest, and impairing cell migration. Melatonin was found to enhance the anticancer effects of PtDPhPzTn, increasing apoptosis and inhibiting cell migration when used together.
Article
Biology
Ignacio Bejarano, Monica Dorado-Silva, Helia Sarmiento-Soto, Nuria Alvarez-Sanchez, Patricia Judith Lardone, Juan Miguel Guerrero, Pascual Sanchez-Martin, Antonio Carrillo-Vico
Summary: Despite advances in assisted reproduction technology, success rates remain low. The study found that the expression of GPX3 in cumulus cells was significantly reduced in embryos that successfully implanted, suggesting its potential as a poor prognostic indicator of implantation success.