Journal
ENVIRONMENTAL POLLUTION
Volume 284, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2021.117508
Keywords
PFOS; Oocyte quality; Meiotic competency; Fertilization ability; Apoptosis
Categories
Funding
- National Key Research and Development Program of China [2018YFC1003802]
Ask authors/readers for more resources
The study reveals that exposure to PFOS affects the quality of oocytes by disrupting meiotic competency, cytoskeleton assembly, and mitochondrial function, leading to oxidative stress-induced apoptosis.
Perfluorooctane sulfonate (PFOS) is a widely used artificial surfactant with potential toxicity to humans and animals. However, little is known about the impact of PFOS on the female germ cell development. Here, we report that PFOS exposure weakens oocyte quality by disturbing oocyte meiotic competency and fertilization ability. Specifically, PFOS exposure impaired cytoskeleton assembly including spindle organization and actin polymerization to cause the oocyte maturation arrest. In addition, PFOS exposure also impaired the mitochondrial dynamics and function, resulting in the increased levels of reactive oxygen species (ROS) and DNA damage as well as generation of apoptosis. Lastly, PFOS exposure compromised the distribution of cortical granules (CGs) and their component ovastacin, leading to the failure of sperm binding and fertilization. Altogether, our study illustrates that oxidative stress-induced apoptosis is a major cause for the deteriorated quality of porcine oocytes exposed to PFOS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available