Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models

Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus

(2012) Akiko Sheala Shingo et al.   BEHAVIOURAL BRAIN RESEARCH

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice

(2012) Chloe Boitard et al.   HIPPOCAMPUS

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Screening Cognition in the Elderly with Metabolic Syndrome

(2012) Giovanni Viscogliosi et al.   Metabolic Syndrome and Related Disorders

Insulin in the Brain: Sources, Localization and Functions

(2012) Rasoul Ghasemi et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals

(2012) David Heras-Sandoval et al.   NEUROCHEMICAL RESEARCH

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

(2012) Kendra L. Puig et al.   PLoS One

High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission

(2011) Ismael Valladolid-Acebes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

(2011) Tomoko Kuwabara et al.   EMBO Molecular Medicine

Vascular Changes in Rat Hippocampus following a High Saturated Fat and Cholesterol Diet

(2011) Linnea R Freeman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

(2011) Elad Shemesh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents

(2011) Brian C. Shonesy et al.   NEUROBIOLOGY OF AGING

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Encephalopathies: the emerging diabetic complications

(2010) Anders A. F. Sima   ACTA DIABETOLOGICA

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes

(2010) W. Xu et al.   DIABETES

Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

(2010) Rosemarie Krug et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin receptor signaling in the development of neuronal structure and function

(2010) Shu-Ling Chiu et al.   Neural Development

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Insulin regulates Presenilin 1 localization via PI3K/Akt signaling

(2010) Masato Maesako et al.   NEUROSCIENCE LETTERS

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?

(2009) H. Umegaki   AGE AND AGEING

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

P88 Syndrome métabolique et risque de maladie d’Alzheimer ou de démence vasculaire incidente : étude au sein de la cohorte 3C

(2009) C. Raffaitin et al.   DIABETES & METABOLISM

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

(2009) Paula L. McClean et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

(2009) V. Solfrizzi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

(2009) D. R. Marks et al.   JOURNAL OF NEUROSCIENCE

A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia

(2009) Rahul Agrawal et al.   NEUROPHARMACOLOGY

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

(2008) Susan A. Farr et al.   ENDOCRINOLOGY

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock-in mice

(2008) Christa M. Studzinski et al.   JOURNAL OF NEUROCHEMISTRY

Expression of Insulin System in the Olfactory Epithelium: First Approaches to its Role and Regulation

(2008) M.-C. Lacroix et al.   JOURNAL OF NEUROENDOCRINOLOGY

Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

(2008) L. Sui et al.   LEARNING & MEMORY

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Sucrose-induced obesity impairs novel object recognition learning in young rats

(2008) Nicole Jurdak et al.   PHYSIOLOGY & BEHAVIOR

Acute stress or systemic insulin injection increases flunitrazepam sensitive-GABAAreceptor density in synaptosomes of chick forebrain: Modulation by systemic epinephrine

(2008) Mariana Paula Cid et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS