Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus

(2019) Antonis Fanouriakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, chronic, corticosteroid-dependent systemic lupus erythematosus: effect of conditioning regimen on outcome

(2018) Richard K. Burt et al.   BONE MARROW TRANSPLANTATION

The correlations of psychological status, quality of life, self-esteem, social support and body image disturbance in Chinese patients with Systemic Lupus Erythematosus

(2018) Qian Zhao et al.   Psychology Health & Medicine

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410

(2018) Liyang Dong et al.   Cell Death & Disease

Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis

(2018) S. Esmaeil Dorraji et al.   Scientific Reports

Therapeutic efficacy and adverse events of hydroxychloroquine administration in Japanese systemic/cutaneous lupus erythematosus patients

(2018) Chikako Kishi et al.   JOURNAL OF DERMATOLOGY

MicroRNA‑139‑5p elevates skeletal myogenic differentiation of human adult dental pulp stem cells through Wnt/β‑catenin signaling pathway

(2018) Yufei Xie et al.   Experimental and Therapeutic Medicine

Osteogenesis and aging: lessons from mesenchymal stem cells

(2018) Arantza Infante et al.   Stem Cell Research & Therapy

Therapeutic potential of allogeneic mesenchymal stromal cells transplantation for lupus nephritis

(2018) J Barbado et al.   LUPUS

Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study

(2018) Jun Liang et al.   Stem Cell Research & Therapy

Stem Cells Derived from Lipoma and Adipose Tissue—Similar Mesenchymal Phenotype but Different Differentiation Capacity Governed by Distinct Molecular Signature

(2018) Sanja Stojanović et al.   Cells

Down-regulation of Noggin and miR-138 coordinately promote osteogenesis of mesenchymal stem cells

(2017) Xing-Kun Sun et al.   JOURNAL OF MOLECULAR HISTOLOGY

Bone marrow-derived mesenchymal stem cells inhibit T follicular helper cell in lupus-prone mice

(2017) X Yang et al.   LUPUS

The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs

(2017) Juan Liu et al.   Current Stem Cell Research & Therapy

Intra-Articular Injection of Human Synovial Membrane-Derived Mesenchymal Stem Cells in Murine Collagen-Induced Arthritis: Assessment of Immunomodulatory Capacity In Vivo

(2017) Minglu Yan et al.   Stem Cells International

Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-β Feedback Loop

(2017) Lin Gao et al.   Arthritis & Rheumatology

Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis

(2017) Narae Park et al.   Scientific Reports

Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial

(2016) Jose M Álvaro-Gracia et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical Trials with Mesenchymal Stem Cells: An Update

(2016) Tiziana Squillaro et al.   CELL TRANSPLANTATION

Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study

(2016) Dandan Wang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

TNF-α inhibitors reduce the pathological Th1-Th17/Th2imbalance in cutaneous mesenchymal stem cells of psoriasis patients

(2016) Anna Campanati et al.   EXPERIMENTAL DERMATOLOGY

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

(2016) Madhvi Menon et al.   IMMUNITY

Decreased osteogenesis in mesenchymal stem cells derived from the aged mouse is associated with enhanced NF-κB activity

(2016) Tzu-hua Lin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus

(2016) J Zhao et al.   LUPUS

Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations

(2016) Michaela Hajkova et al.   Stem Cell Reviews and Reports

Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression

(2016) Lindsay C. Davies et al.   STEM CELLS

Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations

(2016) Michaela Hajkova et al.   Stem Cell Reviews and Reports

Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria

(2016) Jinyun Chen et al.   Stem Cells International

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

(2016) Mariano Di Trapani et al.   Scientific Reports

Mesenchymal stem cell transplantation can restore lupus disease-associated miRNA expression and Th1/Th2 ratios in a murine model of SLE

(2016) Eun Wha Choi et al.   Scientific Reports

Endoplasmic reticulum stress participates in the progress of senescence of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus

(2015) Zhifeng Gu et al.   CELL AND TISSUE RESEARCH

Bone marrow mesenchymal stem cells suppressing activation of allogeneic cytokine-induced killer/natural killer cells either by direct or indirect interaction

(2015) Yang Li et al.   CELL BIOLOGY INTERNATIONAL

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

(2015) Dandan Wang et al.   Cellular & Molecular Immunology

Human Vascular Wall Mesenchymal Stromal Cells Contribute to Abdominal Aortic Aneurysm Pathogenesis Through an Impaired Immunomodulatory Activity and Increased Levels of Matrix Metalloproteinase-9

(2015) Carmen Ciavarella et al.   CIRCULATION JOURNAL

PTEN/Akt-p27kip1Signaling Promote the BM-MSCs Senescence and Apoptosis in SLE Patients

(2015) Wei Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MAVS Coordination of Antiviral Innate Immunity

(2015) Christine Vazquez et al.   JOURNAL OF VIROLOGY

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards

(2015) Hafsa Munir et al.   STEM CELLS AND DEVELOPMENT

Extracellular Vesicles Secreted by Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stromal Cells Fail to Suppress Lymphocyte Proliferation

(2015) Ana Valéria Gouveia de Andrade et al.   STEM CELLS AND DEVELOPMENT

The molecular basis for functional plasticity in type I interferon signaling

(2015) Gideon Schreiber et al.   TRENDS IN IMMUNOLOGY

Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus

(2015) Haifeng Chen et al.   Arthritis & Rheumatology

Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study

(2015) Jiwon Hwang et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Childhood onset systemic lupus erythematosus: how is it different from adult SLE?

(2014) Amita Aggarwal et al.   International Journal of Rheumatic Diseases

High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus

(2014) D. Shi et al.   PATHOLOGIE BIOLOGIE

Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus

(2014) Tony N. Marion et al.   Seminars in Immunopathology

Human Mesenchymal Stromal Cells from Adult and Neonatal Sources: A Comparative In Vitro Analysis of Their Immunosuppressive Properties Against T Cells

(2014) Marta E. Castro-Manrreza et al.   STEM CELLS AND DEVELOPMENT

A CD8 T Cell/Indoleamine 2,3-Dioxygenase Axis Is Required for Mesenchymal Stem Cell Suppression of Human Systemic Lupus Erythematosus

(2014) Dandan Wang et al.   Arthritis & Rheumatology

Association of TNF-αwith Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

(2014) Linyu Geng et al.   Journal of Immunology Research

Overexpression of dnIKK in mesenchymal stem cells leads to increased migration and decreased invasion upon TNFα stimulation

(2013) Florian Haasters et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combination Cell Therapy Using Mesenchymal Stem Cells and Regulatory T-Cells Provides a Synergistic Immunomodulatory Effect Associated with Reciprocal Regulation of Th1/Th2 and Th17/Treg Cells in a Murine Acute Graft-Versus-Host Disease Model

(2013) Jung-Yeon Lim et al.   CELL TRANSPLANTATION

Molecular Pathways: Human Leukocyte Antigen G (HLA-G)

(2013) G. Curigliano et al.   CLINICAL CANCER RESEARCH

Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway

(2013) Yingzhe Zhou et al.   CYTOTHERAPY

Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway

(2013) Zhifeng Gu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

(2013) Patricia Luz-Crawford et al.   Stem Cell Research & Therapy

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials

(2012) Susan Manzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus

(2012) William Stohl et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

(2012) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Transplantation for Autoimmune Diseases in North and South America: A Report of the Center for International Blood and Marrow Transplant Research

(2012) Marcelo C. Pasquini et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Mesenchymal stem cells: a double-edged sword in regulating immune responses

(2012) W Li et al.   CELL DEATH AND DIFFERENTIATION

IL-17: A new actor in IFN-driven systemic autoimmune diseases

(2012) Aurélie Ambrosi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Enhanced Apoptosis and Senescence of Bone-Marrow-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

(2012) Xia Li et al.   STEM CELLS AND DEVELOPMENT

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

(2011) E. Sanchez et al.   ANNALS OF THE RHEUMATIC DISEASES

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

The immunomodulatory capacity of mesenchymal stem cells

(2011) Antje Gebler et al.   TRENDS IN MOLECULAR MEDICINE

Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study

(2010) J. Liang et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon-γ-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus

(2010) Francesca Schena et al.   ARTHRITIS AND RHEUMATISM

B Cell-Targeted Therapies for Systemic Lupus Erythematosus

(2010) R. John Looney   DRUGS

Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses

(2010) Amit Golding et al.   IMMUNOLOGY

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus

(2010) Y. Nie et al.   LUPUS

Efficacy and Adverse Events of Mycophenolate Mofetil Versus Cyclophosphamide for Induction Therapy of Lupus Nephritis

(2010) Nanticha Kamanamool et al.   MEDICINE

Frequency and determinants of flare and persistently active disease in systemic lupus erythematosus

(2009) Mandana Nikpour et al.   ARTHRITIS AND RHEUMATISM

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

(2009) Lindolfo da Silva Meirelles et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF- -Producing CD8+ Treg Cells Are Associated with Immunological Remission of Lupus

(2009) L. Zhang et al.   JOURNAL OF IMMUNOLOGY

Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients

(2009) F. Carrion et al.   LUPUS

A perspective on B-cell-targeting therapy for SLE

(2009) R. John Looney et al.   Modern Rheumatology

Mesenchymal Stem Cell Transplantation Reverses Multiorgan Dysfunction in Systemic Lupus Erythematosus Mice and Humans

(2009) Lingyun Sun et al.   STEM CELLS

Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by interleukins 2, 7 and 15

(2008) C Bocelli-Tyndall et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α–producing antigen-presenting cells

(2008) Bing Yan et al.   ARTHRITIS AND RHEUMATISM

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases

(2008) I. L. Weissman et al.   BLOOD

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes

(2008) S. Tabera et al.   HAEMATOLOGICA

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Bone Marrow-Derived Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated from Healthy Donors and Systemic Lupus Erythematosus Patients

(2007) Elisabetta Traggiai et al.   STEM CELLS

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS