PTEN/Akt-p27kip1Signaling Promote the BM-MSCs Senescence and Apoptosis in SLE Patients

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress

(2012) Gulinuer Muteliefu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance

(2012) Ning Kong et al.   ARTHRITIS AND RHEUMATISM

Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients

(2012) Zhifeng Gu et al.   CELLULAR SIGNALLING

Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice

(2012) Fei Gu et al.   CLINICAL IMMUNOLOGY

AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells

(2012) Fengju OuYang et al.   FOOD CHEMISTRY

Enhanced Apoptosis and Senescence of Bone-Marrow-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

(2012) Xia Li et al.   STEM CELLS AND DEVELOPMENT

Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis

(2011) Min-Jung Park et al.   ARTHRITIS AND RHEUMATISM

Rb1 Protects Endothelial Cells from Hydrogen Peroxide-Induced Cell Senescence by Modulating Redox Status

(2011) Ding-Hui Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

JNK signaling activity regulates cell–cell adhesions via TM4SF5-mediated p27Kip1 phosphorylation

(2011) Hyeonjung Kim et al.   CANCER LETTERS

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Hydrogen Sulfide and l-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase Cζ/λ (PKCζ/λ) in 3T3l1 Adipocytes

(2011) Prasenjit Manna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amelioration of Experimental Autoimmune Encephalomyelitis by β-elemene Treatment is Associated with Th17 and Treg Cell Balance

(2011) Rongwei Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study

(2010) J. Liang et al.   ANNALS OF THE RHEUMATIC DISEASES

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

(2010) Amber Wilson et al.   BMC GENOMICS

PI(3)King Apart PTEN's Role in Cancer

(2010) S. Zhang et al.   CLINICAL CANCER RESEARCH

Allogenic bone-marrow-derived mesenchymal stem cells transplantation as a novel therapy for systemic lupus erythematosus

(2010) Huayong Zhang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bone Marrow Mesenchymal Stem Cells: Historical Overview and Concepts

(2010) Pierre Charbord   HUMAN GENE THERAPY

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation

(2010) Flavio Carrión et al.   IMMUNOLOGY LETTERS

House Dust Mite Sublingual Immunotherapy

(2009) Robyn E. O'Hehir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients

(2009) F. Carrion et al.   LUPUS

Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

(2009) J L Attema et al.   ONCOGENE

Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells

(2009) Jun-Young Heo et al.   STEM CELLS

Tuberin, p27 and mTOR in different cells

(2008) S. Burgstaller et al.   AMINO ACIDS

AMP-Activated Protein Kinase Signaling Results in Cytoplasmic Sequestration of p27

(2008) J. D. Short et al.   CANCER RESEARCH

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

The death domain-containing kinase RIP1 regulates p27Kip1 levels through the PI3K–Akt–forkhead pathway

(2008) Seongmi Park et al.   EMBO REPORTS

Id-1 activates Akt-mediated Wnt signaling and p27Kip1 phosphorylation through PTEN inhibition

(2008) J-Y Lee et al.   ONCOGENE