Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice

(2014) Y. Fujita et al.   JOURNAL OF IMMUNOLOGY

Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells

(2013) Sadik H. Kassim et al.   CELLULAR IMMUNOLOGY

Leptin promotes lupus T-cell autoimmunity

(2013) Gil Amarilyo et al.   CLINICAL IMMUNOLOGY

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation

(2013) Ramesh Yentrapalli et al.   PLoS One

Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice

(2012) Fei Gu et al.   CLINICAL IMMUNOLOGY

Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

(2012) Ding-Lei Su et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Apoptosis and Senescence of Bone-Marrow-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

(2012) Xia Li et al.   STEM CELLS AND DEVELOPMENT

The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro

(2011) Shuang Liu et al.   AGING CELL

Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases

(2011) Gordon I. A. MacDonald et al.   ARTHRITIS AND RHEUMATISM

Cell Contact Accelerates Replicative Senescence of Human Mesenchymal Stem Cells Independent of Telomere Shortening and p53 Activation: Roles of Ras and Oxidative Stress

(2011) Jennifer H. Ho et al.   CELL TRANSPLANTATION

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Reversal of aging by NFκB blockade

(2010) Adam S. Adler et al.   CELL CYCLE

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

(2010) Sona Hubackova et al.   CELL CYCLE

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth

(2010) Serif Senturk et al.   HEPATOLOGY

Mesenchymal Stromal Cells

(2009) Maria Ester Bernardo et al.   Annals of the New York Academy of Sciences

Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis

(2009) A.E. Kerstetter et al.   EXPERIMENTAL NEUROLOGY

Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients

(2009) F. Carrion et al.   LUPUS

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Inflammatory signaling and cellular senescence

(2008) Jian-Lin Ren et al.   CELLULAR SIGNALLING

Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study

(2008) Motoko Sasaki et al.   FREE RADICAL RESEARCH

Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

(2008) Kwang Seok Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One