Development of protein mimics for intracellular delivery

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guanidinium-Rich, Glycerol-Derived Oligocarbonates: A New Class of Cell-Penetrating Molecular Transporters That Complex, Deliver, and Release siRNA

(2015) Paul A. Wender et al.   MOLECULAR PHARMACEUTICS

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

(2014) Wenyi Li et al.   AMINO ACIDS

Competitive interactions of amphipathic polycationic peptides and cationic fluorescent probes with lipid membrane: Experimental approaches and computational model

(2014) Victor V. Lemeshko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Importance of Sequence Specific Hydrophobicity in Synthetic Protein Transduction Domain Mimics

(2014) Federica Sgolastra et al.   BIOMACROMOLECULES

Design of Aromatic-Containing Cell-Penetrating Peptide Mimics with Structurally Modified π Electronics

(2014) Brittany M. deRonde et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

(2014) Giulio Gasparini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation

(2014) Ilja Tabujew et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Antifungal Plant Defensins: Mechanisms of Action and Production

(2014) Kim Vriens et al.   MOLECULES

Orthogonal functionalisation of α-helix mimetics

(2014) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antimicrobial peptides from scorpion venoms

(2014) Patrick L. Harrison et al.   TOXICON

Designing Mimics of Membrane Active Proteins

(2013) Federica Sgolastra et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fifteen Years of Cell-Penetrating, Guanidinium-Rich Molecular Transporters: Basic Science, Research Tools, and Clinical Applications

(2013) Erika Geihe Stanzl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of Functionalizable and Degradable Polymers by Ring-Opening Metathesis Polymerization

(2013) Joshua M. Fishman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors

(2013) Patrick T. Weiser et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic Aspects of Peptide-Membrane Interactions Determined by Optical, Dielectric and Piezoelectric Techniques: An Overview

(2013) Maria Oliveira et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Defensin-based anti-infective strategies

(2013) Miriam Wilmes et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

(2013) Eun-Kyoung Bang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers

(2013) Haruko Takahashi et al.   MACROMOLECULAR BIOSCIENCE

Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-Negative Activity

(2013) Hitesh D. Thaker et al.   ACS Medicinal Chemistry Letters

Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and Anti-Inflammatory Activities

(2012) Abhigyan Som et al.   Clinical and Vaccine Immunology

Recent Advances in Computational Modeling of α.-Helical Membrane- Active Peptides

(2012) Anton Polyansky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Arginine in α-Defensins

(2012) Nathan W. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Nanoscopic Membrane Curvature Generation from Quantum Mechanical Models and Synthetic Transporter Sequences

(2012) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses

(2012) Hitesh D. Thaker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells

(2012) A. Özgül Tezgel et al.   MOLECULAR THERAPY

Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

(2012) E. I. Geihe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial polymers as synthetic mimics of host-defense peptides

(2012) Kenichi Kuroda et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Poly(disulfide)s

(2012) Eun-Kyoung Bang et al.   Chemical Science

Self-Activation in De Novo Designed Mimics of Cell-Penetrating Peptides

(2011) Abhigyan Som et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Transduction Domain Mimics: The Role of Aromatic Functionality

(2011) Abhigyan Som et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

De Novo Designed Protein Transduction Domain Mimics from Simple Synthetic Polymers

(2011) A. Özgül Tezgel et al.   BIOMACROMOLECULES

Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action

(2011) Maria Luisa Mangoni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

(2011) Marco Scocchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds

(2011) Hitesh D. Thaker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization

(2011) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Guanidine-Containing Methacrylamide (Co)polymers via aRAFT: Toward a Cell-Penetrating Peptide Mimic

(2011) Nicolas J. Treat et al.   ACS Macro Letters

PEP and CADY-mediated delivery of fluorescent peptides and proteins into living cells

(2010) Laetitia Kurzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Overview on Plant Antimicrobial Peptides

(2010) Ana Maria Benko-Iseppon et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Computational studies of protegrin antimicrobial peptides: A review

(2010) Dan S. Bolintineanu et al.   PEPTIDES

Bioreducible polymers for gene delivery

(2010) Tae-il Kim et al.   REACTIVE & FUNCTIONAL POLYMERS

Polymers for Drug Delivery Systems

(2010) William B. Liechty et al.   Annual Review of Chemical and Biomolecular Engineering

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanisms of Antimicrobial, Cytolytic, and Cell-Penetrating Peptides: From Kinetics to Thermodynamics

(2009) Paulo F. Almeida et al.   BIOCHEMISTRY

Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity

(2009) Semra Colak et al.   BIOMACROMOLECULES

A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems

(2009) Tae-il Kim et al.   BIOMATERIALS

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent advances in the development of aryl-based foldamers

(2009) Ishu Saraogi et al.   CHEMICAL SOCIETY REVIEWS

Antimicrobial Polymers Prepared by Ring-Opening Metathesis Polymerization: Manipulating Antimicrobial Properties by Organic Counterion and Charge Density Variation

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

“Doubly Selective” Antimicrobial Polymers: How Do They Differentiate between Bacteria?

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation

(2009) Mei Ou et al.   JOURNAL OF CONTROLLED RELEASE

General Synthetic Route to Cell-Permeable Block Copolymers via ROMP

(2009) Erin M. Kolonko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

(2009) Christina B. Cooley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer Scaffolds for Biomaterials Applications

(2009) Molly S. Shoichet   MACROMOLECULES

The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

(2009) Dries Vercauteren et al.   MOLECULAR THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Foldamers with Heterogeneous Backbones

(2008) W. Seth Horne et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antimicrobial peptide mimics for improved therapeutic properties

(2008) Shahar Rotem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Novel Biodegradable Poly(disulfide amine)s for Gene Delivery with High Efficiency and Low Cytotoxicity

(2008) Mei Ou et al.   BIOCONJUGATE CHEMISTRY

Cell-penetrating peptides: from molecular mechanisms to therapeutics

(2008) May C. Morris et al.   BIOLOGY OF THE CELL

Synthetic Mimic of Antimicrobial Peptide with Nonmembrane-Disrupting Antibacterial Properties

(2008) Gregory J. Gabriel et al.   BIOMACROMOLECULES

Investigating the Effect of Increasing Charge Density on the Hemolytic Activity of Synthetic Antimicrobial Polymers

(2008) Zoha M. AL-Badri et al.   BIOMACROMOLECULES

Cardiomyocyte-targeted siRNA delivery by prostaglandin E2-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis

(2008) Sun Hwa Kim et al.   BIOMATERIALS

Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems

(2008) Tae-il Kim et al.   BIOMATERIALS

Synthetic mimics of antimicrobial peptides

(2008) Abhigyan Som et al.   BIOPOLYMERS

De novo designed synthetic mimics of antimicrobial peptides

(2008) Richard W Scott et al.   CURRENT OPINION IN BIOTECHNOLOGY

Peptide-Based Nanoparticle for Ex Vivo and In Vivo Dug Delivery

(2008) Laurence Crombez et al.   CURRENT PHARMACEUTICAL DESIGN

A Polymeric Domain That Promotes Cellular Internalization

(2008) Erin M. Kolonko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stimuli-Responsive Polyguanidino-Oxanorbornene Membrane Transporters as Multicomponent Sensors in Complex Matrices

(2008) Andreas Hennig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach

(2008) Karen Lienkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Disinfecting Antimicrobial Surfaces

(2008) Ahmad E. Madkour et al.   LANGMUIR

VEGF siRNA Delivery System Using Arginine-Grafted Bioreducible Poly(disulfide amine)

(2008) Sun Hwa Kim et al.   MOLECULAR PHARMACEUTICS

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY

Synthesis and characterization of amphiphilic o-phenylene ethynylene oligomers

(2008) Morris M. Slutsky et al.   NEW JOURNAL OF CHEMISTRY

Extending helicity—capturing the helical character of longer ortho-phenylene ethynylene oligomers

(2008) Ticora V. Jones et al.   NEW JOURNAL OF CHEMISTRY

Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

(2008) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The design of guanidinium-rich transporters and their internalization mechanisms

(2007) Paul A. Wender et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy

(2007) Sébastien Deshayes et al.   ADVANCED DRUG DELIVERY REVIEWS

Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans

(2007) André Ziegler   ADVANCED DRUG DELIVERY REVIEWS

Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery

(2007) Chao Lin et al.   JOURNAL OF CONTROLLED RELEASE

Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers

(2007) Gregory J. Gabriel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY