Extracellular Vesicles as Natural, Safe and Efficient Drug Delivery Systems

Improved loading of plasma derived-extracellular vesicles to encapsulate antitumor miRNAs

(2019) Margherita Alba Carlotta Pomatto et al.   Molecular Therapy-Methods & Clinical Development

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

(2019) María Sancho-Albero et al.   JOURNAL OF NANOBIOTECHNOLOGY

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

(2019) Christina Schindler et al.   PLoS One

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells

(2019) Catharina Melzer et al.   Cancers

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

(2018) M. Garofalo et al.   JOURNAL OF CONTROLLED RELEASE

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

(2018) Jing-Hung Wang et al.   MOLECULAR CANCER THERAPEUTICS

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Optimizing exosomal RNA isolation for RNA-Seq analyses of archival sera specimens

(2018) Emily N. Prendergast et al.   PLoS One

Exosome isolation from distinct biofluids using precipitation and column-based approaches

(2018) Tânia Soares Martins et al.   PLoS One

An improvised one-step sucrose cushion ultracentrifugation method for exosome isolation from culture supernatants of mesenchymal stem cells

(2018) Suchi Gupta et al.   Stem Cell Research & Therapy

Rapid Detection and Trapping of Extracellular Vesicles by Electrokinetic Concentration for Liquid Biopsy on Chip

(2018) Lucia Cheung et al.   Micromachines

Comparison of an Optimized Ultracentrifugation Method versus Size-Exclusion Chromatography for Isolation of Exosomes from Human Serum

(2018) Mingrui An et al.   JOURNAL OF PROTEOME RESEARCH

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display

(2018) Travis J. Antes et al.   JOURNAL OF NANOBIOTECHNOLOGY

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

(2018) Senthilkumar Kalimuthu et al.   Frontiers in Pharmacology

Exosomes from human placenta purified by affinity chromatography on sepharose bearing immobilized antibodies against CD81 tetraspanin contain many peptides and small proteins

(2018) Evgeniya E. Burkova et al.   IUBMB LIFE

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

(2018) Mariangela Garofalo et al.   Viruses-Basel

To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles

(2018) Gina D. Kusuma et al.   Frontiers in Pharmacology

Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma

(2018) Zsófia Onódi et al.   Frontiers in Physiology

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

(2017) Wei Jiang Goh et al.   International Journal of Nanomedicine

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

(2017) Giulia Corso et al.   Scientific Reports

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

(2016) Jina Ko et al.   ANALYST

In Vivo Delivery Systems for Therapeutic Genome Editing

(2016) Luyao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Surface Glycoproteins of Exosomes Shed by Myeloid-Derived Suppressor Cells Contribute to Function

(2016) Sitara Chauhan et al.   JOURNAL OF PROTEOME RESEARCH

Exosomes in tumor microenvironment: novel transporters and biomarkers

(2016) Zhen Wang et al.   Journal of Translational Medicine

Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation

(2016) Agata Abramowicz et al.   Molecular BioSystems

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

(2016) Mohamad Hadla et al.   Nanomedicine

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

(2016) Akhil Srivastava et al.   Scientific Reports

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Residual matrix from different separation techniques impacts exosome biological activity

(2016) Lucia Paolini et al.   Scientific Reports

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

(2016) Barbara W Sódar et al.   Scientific Reports

Trehalose prevents aggregation of exosomes and cryodamage

(2016) Steffi Bosch et al.   Scientific Reports

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics

(2015) Sybren L.N. Maas et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin

(2015) Giuseppe Toffoli et al.   Nanomedicine

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method

(2015) Daniel Enderle et al.   PLoS One

Heparin affinity purification of extracellular vesicles

(2015) Leonora Balaj et al.   Scientific Reports

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol

(2015) Mikhail A. Livshits et al.   Scientific Reports

Should Cell Culture Platforms Move towards EV Therapy Requirements?

(2015) Ana Aiastui   Frontiers in Immunology

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

(2015) Tamás Baranyai et al.   PLoS One

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry

(2014) Uta Erdbrügger et al.   CYTOMETRY PART A

Isolation of biologically-active exosomes from human plasma

(2014) Laurent Muller et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells

(2013) Karin Ekström et al.   PLoS One

Cryogenic Transmission Electron Microscopy Nanostructural Study of Shed Microparticles

(2013) Liron Issman et al.   PLoS One

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Immature Dendritic Cell-Derived Exosomes: a Promise Subcellular Vaccine for Autoimmunity

(2012) Weifan Yin et al.   INFLAMMATION

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Impact of Biofluid Viscosity on Size and Sedimentation Efficiency of the Isolated Microvesicles

(2012) Fatemeh Momen-Heravi et al.   Frontiers in Physiology

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Increasing vaccine potency through exosome antigen targeting

(2011) Zachary C. Hartman et al.   VACCINE

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages

(2010) Yukihiro Akao et al.   MOLECULAR THERAPY

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA