Article
Environmental Sciences
Arshad Ali, Ayaz Ali, Hema S. S. Devi, Jayasimha R. R. Daddam, Rabiah Sarwar, Farheen Khan Badrealam
Summary: The aim of this study was to identify an efficacious, novel therapeutic biomarker for the successful diagnosis of lung cancer at the early stage of the disease and the molecular insights involved. The expression levels of HDAC2 and YY1 were found to be upregulated in lung cancer cell lines and tumor samples. Inhibition of HDAC2 reduced YY1 expression, and knockdown of YY1 inhibited proliferation, migration, invasion, and cell cycle progression in lung cancer cell lines by suppressing c-Myc. These findings suggest that HDAC2's anticancer role may be attributed to YY1 regulation and it could serve as a potential novel candidate biomarker for lung cancer diagnosis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Zhiqiang Sun, Qingqing Xu, Yali Ma, Suxia Yang, Jun Shi
Summary: Upregulation of circ_0000524 and CXCL16, as well as low expression of miR-500a-5p, were observed in MN tissues. In cell experiments, circ_0000524 was found to regulate podocyte apoptosis through modulating miR-500a-5p and CXCL16.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Jingfeng Gu, Liang Dong, Yun Wang, Wenjia Nie, Wencong Liu, Ji-an Zhao
Summary: YY1-induced LINC01224 regulates CRC development by modulating the miR-485-5p/MYO6 axis. LINC01224 sponges miR-485-5p to influence its regulation on CRC, while upregulation of miR-485-5p suppresses proliferation, migration, and invasion of CRC cells and promotes apoptosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhigang Zhao, Shankun Zhao, Lianmin Luo, Qian Xiang, Zhiguo Zhu, Jiamin Wang, Yangzhou Liu, Jintai Luo
Summary: The study demonstrates a tumor-suppressive role of miR-199b-5p in invasion and metastasis of PCa by inhibiting DDR1 expression and EMT, leading to poor prognosis in patients. Additionally, the miR-199b-5p-DDR1-ERK signaling axis represents a novel mechanism for regulating EMT in PCa metastases.
BRITISH JOURNAL OF CANCER
(2021)
Article
Neurosciences
Xin Lin, Yang Yang, Ye Ji, Guangxi Wang, Wenbo Xu, Bo Wang, Hangyu Guo, Jiyu Ren, Jinglong Yan, Nanxiang Wang
Summary: Spinal cord injury (SCI) leads to glial scar formation, inhibiting axonal growth and neurological recovery. The miR-135a-5p/SP1 axis regulates astrocyte proliferation and migration, providing a potential target for effective SCI treatment.
Article
Environmental Sciences
Guanghui Wang, Xiyuan Wei, Shan Gao, Wenheng Chen, Yang Geng, Jia Liu, Hongya Guan
Summary: Circ_LRP6 plays a role in the occurrence and development of osteosarcoma by affecting the proliferation, migration, and invasion of osteosarcoma cells. It interacts with miR-122-5p and miR-204-5p and modulates their target gene HMGB1. The downregulation of miR-122-5p and miR-204-5p and the overexpression of HMGB1 partially restore and weaken the inhibitory effect of circ_LRP6 on osteosarcoma progression.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Wen Li, Shanshan Wang, Boquan Shan, Xiang Cheng, Hui He, Jianbing Qin, Yi Tang, Heyan Zhao, Meiling Tian, Xinhua Zhang, Guohua Jin
Summary: The study demonstrates that circHECTD1 promotes proliferation and migration of GBM cells by interacting with miR-320-5p and binding with SLC2A1 to enhance tumor growth.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Carmen Asensio-Lopez, Yassine Sassi, Fernando Soler, Maria Josefa Fernandez del Palacio, Domingo Pascual-Figal, Antonio Lax
Summary: Elevation of miR-199a-5p post-myocardial infarction leads to pathological cardiac hypertrophy by increasing soluble sST2 levels. AntimiR199a therapy regulates Sirt1 and inactivates P300 protein to inhibit Yy1, reducing sST2 release by cardiomyocytes after myocardial infarction. Pharmacological inhibition of miR-199a rescues cardiac hypertrophy and heart failure in mice, offering a potential therapeutic approach for cardiac failure.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Veterinary Sciences
Xueli Xu, Hui Lu, Dong Xu, Zonggang Yu, Nini Ai, Kaiming Wang, Xintong Li, Jun He, Jun Jiang, Haiming Ma, Yuebo Zhang
Summary: miR-708-5p plays a crucial role in skeletal muscle development, inhibiting cell proliferation and promoting differentiation in C2C12 myoblasts. Its target genes are significantly enriched in pathways related to muscle growth and development, with Pik3ca, Pik3r3, and Irs1 identified as key target genes.
VETERINARY SCIENCES
(2022)
Article
Oncology
Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Chen
Summary: This study investigates the regulatory effect of the circ_0084043-miR-134-5p axis on melanoma and its impact on the expression levels of Pyk2, RAC1, Cyclin D1, MMP2, and MMP9. The results show that PCDH9, regulated by the circ_0084043-miR-134-5p axis, can suppress the malignant behavior of melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weina Wang, Xuyao Dai, Yue Li, Mo Li, Zongqi Chi, Xiaoyu Hu, Zhenshan Wang
Summary: Primary cilia, acting as antennae to sense external signals, play a crucial role in transducing extracellular stimuli into cellular responses. This study identifies a microRNA, miR-669a-5p, that is highly expressed in the cilia-enriched fraction and promotes cilium elongation. Mechanistically, miR-669a-5p targets G3BPs to inhibit HDAC6 expression, which further upregulates AKAP12 expression, ultimately leading to greater cilium length. These findings provide potential therapeutic targets for treating ciliopathies.
Article
Immunology
Misun Kim, Hyein Jo, Yoojung Kwon, Myeong Seon Jeong, Hyun Suk Jung, Youngmi Kim, Dooil Jeoung
Summary: The study demonstrates the pivotal role of the miR-154-5p-MCP1 axis in allergic inflammation, indicating that miR-154-5p can mediate allergic reactions in vitro and in vivo by regulating the expression of MCP1.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yun Zhou, Zhenghong Sha, Yong Yang, Shuimei Wu, Hong Chen
Summary: This study demonstrated that lncRNA NEAT1 regulates the proliferation, invasion, and apoptosis of gastric cancer cells through tumor-associated miRNAs.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Shuai Gong, Yi Zhang, Lina Pang, Liye Wang, Wei He
Summary: This study identifies a novel circular RNA, circ_001722, that is significantly upregulated in osteosarcoma tissues and cells. It is found that downregulation of circ_001722 can suppress the proliferation and invasion of osteosarcoma cells. Further experiments confirm that circ_001722 competitively binds to miR-204-5p and prevents its decrease in the level of RUNX2, thereby promoting the progression of osteosarcoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wen Zhong Liu, Yong Xie, Hong Lu, Hong Cheng, Zhi Rong Zeng, Li Ya Zhou, Ye Chen, Jiang Bin Wang, Yi Qi Du, Nong Hua Lu
Article
Gastroenterology & Hepatology
Fenfen Zhou, Therwa Hamza, Ashley S. Fleur, Yongrong Zhang, Hua Yu, Kevin Chen, Jonathon E. Heath, Ye Chen, Haihui Huang, Hanping Feng
INFLAMMATORY BOWEL DISEASES
(2018)
Article
Cell Biology
Youlian Zhou, Zhitao Ou, Xiaoping Tang, Yongjian Zhou, Haoming Xu, Xianfei Wang, Kang Li, Jie He, Yanlei Du, Hong Wang, Ye Chen, Yuqiang Nie
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Microbiology
Youlian Zhou, Zhenjiang Zech Xu, Yan He, Yunsheng Yang, Le Liu, Qianyun Lin, Yugiang Nie, Mingsong Li, Fachao Zhi, Side Liu, Amnon Amir, Antonio Gonzalez, Anupriya Tripathi, Minhu Chen, Gary D. Wu, Rob Knight, Hongwei Zhou, Ye Chen
Article
Gastroenterology & Hepatology
Bingyun Lu, Jiamin Wang, Jing Li, Le Liu, Ye Chen
Article
Cell Biology
Zhongqiu Wang, Qingxin Wang, Xia Wang, Li Zhu, Jie Chen, Bailin Zhang, Ye Chen, Zhiyong Yuan
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Yan-Ru Chen, Wan-Ying Feng, Yuan-Xiong Cheng, Hao Zhu, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: The study demonstrates that siRNAs designed for knocking down mouse-specific lncRNA AA388235 can induce death in human tumor cells, and similar effects were observed for other mouse-specific lncRNAs selected randomly, suggesting that non-human species-specific lncRNAs can be a potential library for designing siRNAs for tumor treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Review
Cell Biology
Yuan Xie, Kai-Wei Fan, Shi-Xing Guan, Yang Hu, Yi Gao, Wei-Jie Zhou
Summary: LECT2 is a multifunctional protein with chemotactic properties, playing various roles in different physiological and pathological conditions. It has been identified as a potential molecular biomarker and therapeutic target.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wenyi Li, Zhaokun Wu, Weidong Meng, Chaoting Zhang, Mingzhen Cheng, Yuehong Chen, Yini Zou, Kejun Li, Simin Lin, Wenjun Xiong, Ying Wang, Yixiong Lin, Wenhui Ma, Weijie Zhou
Summary: This study reveals the significant role of IL-6 in tumor evasion and highlights a novel target to improve the efficacy of immunotherapy in colorectal cancer (CRC). IL-6 overexpression is associated with poor prognosis in CRC. IL-6 deficiency reduces tumor development in mice and leads to high expression of CD8+ T cells in tumors. Furthermore, IL-6 blockade enhances the sensitivity of CRC to anti-PD-1 therapy.
Article
Multidisciplinary Sciences
Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou
Summary: This study identifies a circular RNA called circBNC2, which inhibits G2/M arrest of epithelial cells to prevent fibrosis in damaged kidney and liver, providing a potential target for intervention in fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ze-Tao Zhan, Lu Liu, Ming-Zhen Cheng, Yi Gao, Wei-Jie Zhou
Summary: This study investigated the effects of 6 common antidiabetic drugs on anti-PD1 immune checkpoint inhibitor in tumor treatment. The results showed that acarbose and sitagliptin enhanced tumor inhibition, while glimepiride, pioglitazone, and insulin weakened the tumor inhibition.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wenhui Ma, Zhuoluo Xu, Yutian Wang, Wenyi Li, Zhigang Wei, Tao Chen, Tingyu Mou, Mingzhen Cheng, Jun Luo, Tingyue Luo, Yuehong Chen, Jiang Yu, Weijie Zhou, Guoxin Li
