Article
Dentistry, Oral Surgery & Medicine
Liping Wang, Jingyi Cheng, Junhui Huang, Ting Xiao, Zhangui Tang
Summary: This study demonstrates that IL-13 and its receptor IL-13R alpha 2 are highly expressed in oral submucous fibrosis. IL-13 promotes the proliferation, migration, and secretion of fiber-related proteins in fibroblasts through the PI3K/AKT/mTOR pathway targeting IL-13R alpha 2.
Article
Biochemistry & Molecular Biology
Rui Yang, Yiyong Tang, Jingyi Hou, Menglei Yu, Yi Long, Alike Yamuhanmode, Qingyue Li, Fangqi Li, Yuanhao Zhang, Maslah Warsame, Congda Zhang, Huiyong Shen
Summary: This study explored the role of IL-6 and the PI3K-Akt signaling pathway in the fibrotic process in synovial fibroblasts of frozen shoulder (FS). The findings indicate that IL-6 is up-regulated in FS synovial fibroblasts and promotes fibrosis through the PI3K-Akt signaling pathway.
MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xuelian Zhang, Ming Li, Wenjie Li, Linxiu Yue, Taiyuan Zhang, Qi Tang, Naidan Zhang, Xianyong Lan, Chuanying Pan
Summary: This study aims to investigate the damage of chlorpyrifos (CPF) on male reproduction in pigs and its potential molecular mechanisms. CPF was found to have broad-spectrum toxic effects on ST cells and porcine sperms. RNA sequencing and WB results suggest that CPF may regulate cell survival through the PI3K-AKT pathway. This study may lay the foundation for improving male fertility in pigs and provide theoretical information for human infertility.
Article
Biochemistry & Molecular Biology
Yi Huang, Yun Huang, Ge Zhu, Bingzhi Zhang, Yujia Zhu, Bin Chen, Xiaoxia Gao, Jie Yuan
Summary: A compound named D1399 isolated from Meconopsis grandis Prain has shown strong antitumor activity against lung cancer cells by inducing apoptosis and inhibiting tumor growth, without causing weight loss. This study provides the first evidence for the antitumor activity of D1399 and suggests its potential as a promising candidate for antitumor drug development.
Article
Cell Biology
Jiayang Cai, Zhang Ye, Yuanyuan Hu, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shiao Tong, Shenqi Zhang, Liquan Wu, Ji'an Yang, Qianxue Chen
Summary: In this study, we found that fatostatin induces ferroptosis in glioblastoma by inhibiting the AKT/mTORC1/GPX4 signaling pathway. Fatostatin also inhibits cell proliferation and the EMT process through the AKT/mTORC1 signaling pathway. Additionally, we developed a p28-functionalized PLGA nanoparticle loaded with fatostatin, which can penetrate the blood-brain barrier and target GBM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shuai Zhou, Kang Lin Qu, Jin Ang Li, Shi Lei Chen, Yi Gang Zhang, Chao Zhu, Hao Jin, Yong Wang, Qing Pang, Hui Chun Liu
Summary: The study found that EMI2 is highly expressed in cholangiocarcinoma and promotes the progression of the cancer through the PI3K/Akt signaling pathway. YY1, as one of the transcription factors of EMI2, can reduce the expression of EMI2 when silenced, thereby inhibiting the progression of CCA.
CANCER CELL INTERNATIONAL
(2021)
Article
Plant Sciences
Chang-Min Hsu, Jen-Jie Lin, Jui-Hsin Su, Chih- Liu
Summary: The study found that 13-acetoxysarcocrassolide, extracted from Taiwanese soft coral, could induce apoptosis in hepatocellular carcinoma cells through mitochondrial dysfunction and inactivation of the PI3K/AKT/mTOR/p70S6K pathway. This research is of great significance for evaluating the potential of 13-acetoxysarcocrassolide as a therapeutic agent for hepatocellular carcinoma.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Oncology
Atsushi Ito, Yuichi Akama, Naoko Satoh-Takayama, Kanako Saito, Takuma Kato, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park, Motoshi Takao, Motomu Shimaoka
Summary: This study investigates the dynamic interactions between innate lymphoid cells (ILC2s) and myeloid-derived suppressor cells (MDSCs) during the progression of breast cancer metastasis to the lung. The results show that ILC2s are activated in both micro- and macro-metastatic regions, suggesting sustained activation throughout the metastatic cascade. Furthermore, ILC2s may induce the immunosuppressive functions of MDSCs during the later stages of metastasis, while also instigating extracellular matrix remodeling by activating PMN-MDSCs during the early stages of metastasis.
Article
Biochemistry & Molecular Biology
Xinbing Sui, Xuemeng Han, Peng Chen, Qibiao Wu, Jiao Feng, Ting Duan, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Yu Xiang, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Ruonan Zhang, Bi Chen, Mingming Zhang, Zuyi Yang, Na Kong, Tian Xie, Xia Ding
Summary: Baicalin, a natural active ingredient from Scutellaria baicalensis Georgi, has shown potential antitumor effects against various cancer types. The study revealed that baicalin exerts its antitumor activity mainly by inducing Akt-dependent cell cycle arrest and promoting apoptosis in lung cancer cells, suggesting it may be a promising candidate for developing new drugs for lung cancer treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Geriatrics & Gerontology
Jieting Peng, Xun Xiao, Shizhen Li, Xing Lyu, Hui Gong, Shengyu Tan, Lini Dong, Yan Y. Sanders, Xiangyu Zhang
Summary: This study investigates the effects of aspirin on lung fibroblast differentiation and pulmonary fibrosis. The results show that aspirin reduces the expression of fibrotic markers, promotes autophagy, and decreases lung fibrosis. The mechanism involves the PI3K/AKT/mTOR-dependent autophagy pathway.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Da Eun Hong, Ji Eun Yu, Seung Sik Yoo, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Summary: CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and death. Autophagy is regulated by CHI3L1 through the activation of JNK signaling. CHI3L1 overexpression promotes the formation of autophagosomes, while CHI3L1 depletion reduces their formation. The findings suggest that CHI3L1-induced autophagy could be a novel therapeutic approach to lung cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Ting Hong, Saiqi Li, Xiaoyu Guo, Yazhong Wei, Jingjing Zhang, Xiaohui Su, Miao Zhou, Haizhen Jin, Qing Miao, Lei Shen, Minfang Zhu, Bin He
Summary: IL-13 has been found to have anti-apoptotic effects during sepsis, aiding in the recovery of heart function. This protective effect is likely achieved through enhancing the phosphorylation of STAT3 Ser727 and is associated with ILC2. These findings offer a promising potential treatment for sepsis-induced cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mingyao Qiu, Yusheng Xie, Haiqin Wu, Mingxia Lin
Summary: The study found that DHA can reduce the proliferation of CFs and induce apoptosis through inhibiting the PI3K/AKT pathway, thereby inhibiting myocardial fibrosis. This provides a new potential drug target and direction for the treatment of cardiovascular diseases.
Article
Respiratory System
Zili Zhou, Shixiu Liang, Zicong Zhou, Jieyi Liu, Jinming Zhang, Xiaojing Meng, Fei Zou, Haijin Zhao, Changhui Yu, Shaoxi Cai
Summary: This study found that lung fibroblast activation is associated with airway remodeling during asthma progression. In a mouse asthma model, the inhibition of SCD1 significantly improved airway remodeling and lung fibroblast activation. The study also found that the PI3K-Akt-mTOR-SREBP1 pathway is involved in the regulation of SCD1 expression and lung fibroblast activation. Therefore, the inhibition of SCD1 may be a therapeutic strategy for airway remodeling in asthma.
RESPIRATORY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Huachun Cui, Na Xie, Sami Banerjee, Jing Ge, Sijia Guo, Gang Liu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Review
Physiology
Gang Liu, Ross Summer
ANNUAL REVIEW OF PHYSIOLOGY, VOL 81
(2019)
Article
Biochemistry & Molecular Biology
Tapasi Rana, Chunsun Jiang, Gang Liu, Toshio Miyata, Veena Antony, Victor J. Thannickal, Rui-Ming Liu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Review
Geriatrics & Gerontology
Rui-Ming Liu, Gang Liu
EXPERIMENTAL GERONTOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Dingyuan Jiang, Huachun Cui, Na Xie, Sami Banerjee, Rui-Ming Liu, Huaping Dai, Victor J. Thannickal, Gang Liu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Huachun Cui, Na Xie, Sami Banerjee, Jing Ge, Dingyuan Jiang, Tapan Dey, Qiana L. Matthews, Rui-Ming Liu, Gang Liu
Summary: This study demonstrates that in lung fibrosis, myofibroblasts enhance glycolysis to produce lactate, which regulates the pathogenic phenotype of alveolar macrophages. Lactate induces profibrotic gene expression in macrophages, promoting the fibrotic process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Respiratory System
Dingyuan Jiang, Tapan Dey, Gang Liu
Summary: The latest studies have significantly advanced the understanding of the role and regulation of lung myofibroblasts in lung fibrosis, leading to the emergence of new therapeutic strategies.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Pathology
Chunsun Jiang, Gang Liu, Lu Cai, Jessy Deshane, Veena Antony, Victor J. Thannickal, Rui-Ming Liu
Summary: The increased sensitivity to apoptosis of alveolar type 2 cells (ATII) and the increased resistance to apoptosis of (myo)fibroblasts, known as the apoptosis paradox, could be attributed to the regulation of plasminogen activator inhibitor 1 (PAI-1), which is up-regulated in both cell types in idiopathic pulmonary fibrosis (IPF). The findings suggest that the age-related changes in PAI-1 levels may underlie the apoptosis sensitivity and resistance in ATII and fibroblast cells in IPF lungs. The genetic deletion of PAI-1 in mice led to alterations in p53, p21, and Bax protein expression, impacting the apoptosis response in these cells and ultimately affecting lung fibrosis development.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Fu Jun Li, Ranu Surolia, Huashi Li, Zheng Wang, Gang Liu, Tejaswini Kulkarni, Adriana V. F. Massicano, James A. Mobley, Santanu Mondal, Joao A. de Andrade, Scott A. Coonrod, Paul R. Thompson, Keith Wille, Suzanne E. Lapi, Mohammad Athar, Victor J. Thannickal, A. Brent Carter, Veena B. Antony
Summary: Environmental exposures of cadmium and carbon black were found to increase in lung tissue of idiopathic pulmonary fibrosis (IPF) subjects, leading to higher levels of citrullinated vimentin (Cit-Vim). Cit-Vim was associated with higher expression in IPF patients, especially smokers, and induced fibroblast invasion and fibrosis related gene expression. These findings suggest a potential role for Cit-Vim as a damage-associated molecular pattern molecule in lung fibrosis caused by environmental exposures.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Yan Y. Sanders, Gang Liu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Respiratory System
Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M. Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon
Summary: The study demonstrated that AICAR exerts protective effects in lung injury post exposure to bromine gas by upregulating lung HO-1 levels.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Huachun Cui, Gang Liu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Tapasi Rana, Chunsun Jiang, Sami Banerjee, Nengjun Yi, Jaroslaw W. Zmijewski, Gang Liu, Rui-Ming Liu
Summary: Cellular senescence, especially the senescence of alveolar epithelial type II (ATII) cells, plays a crucial role in aging and aging-related diseases such as idiopathic pulmonary fibrosis (IPF). Plasminogen activator inhibitor 1 (PAI-1), a serine protease inhibitor, was found to bind to proteasome components and inhibit proteasome activity, leading to ATII cell senescence by preventing p53 degradation. This study provides insights into the molecular mechanisms underlying ATII cell senescence and its potential implications for the pathogenesis of lung fibrosis and other age-related diseases.
Article
Medicine, Research & Experimental
Huachun Cui, Dingyuan Jiang, Sami Banerjee, Na Xie, Tejaswini Kulkarni, Rui-Ming Liu, Steven R. Duncan, Gang Liu
Article
Medicine, Research & Experimental
Huachun Cui, Sami Banerjee, Sijia Guo, Na Xie, Jing Ge, Dingyuan Jiang, Martin Zornig, Victor J. Thannickal, Gang Liu