Update on the Role of the Non-Canonical Wnt/Planar Cell Polarity Pathway in Neural Tube Defects

Variants identified in PTK7 associated with neural tube defects

(2019) Yunping Lei et al.   Molecular Genetics & Genomic Medicine

Wnt/PCP Signaling Contribution to Carcinoma Collective Cell Migration and Metastasis

(2019) Kacey VanderVorst et al.   CANCER RESEARCH

De novo Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application

(2019) Weidi Wang et al.   Frontiers in Genetics

Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis

(2018) Hannah Blencowe et al.   Annals of the New York Academy of Sciences

Genetic analysis of Wnt/PCP genes in neural tube defects

(2018) Zhongzhong Chen et al.   BMC Medical Genomics

Threshold for neural tube defect risk by accumulated singleton loss-of-function variants

(2018) Zhongzhong Chen et al.   CELL RESEARCH

Planar cell polarity in organ formation

(2018) Deborah J Henderson et al.   CURRENT OPINION IN CELL BIOLOGY

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Digenic variants of planar cell polarity genes in human neural tube defect patients

(2018) Linlin Wang et al.   MOLECULAR GENETICS AND METABOLISM

Coming to Consensus: A Unifying Model Emerges for Convergent Extension

(2018) Robert J. Huebner et al.   DEVELOPMENTAL CELL

Overview on neural tube defects: From development to physical characteristics

(2018) Laura Avagliano et al.   Birth Defects Research

Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization

(2017) Fares Kharfallah et al.   HUMAN MOLECULAR GENETICS

Planar cell polarity in development and disease

(2017) Mitchell T. Butler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of cellular and PCP signalling by the Scribble polarity module

(2017) Michal Milgrom-Hoffman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Models of convergent extension during morphogenesis

(2017) Asako Shindo   Wiley Interdisciplinary Reviews-Developmental Biology

Inositol, neural tube closure and the prevention of neural tube defects

(2017) Nicholas D.E. Greene et al.   Birth Defects Research

Inositol for the prevention of neural tube defects: a pilot randomised controlled trial

(2016) Nicholas D. E. Greene et al.   BRITISH JOURNAL OF NUTRITION

Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects

(2016) X. Qiao et al.   CLINICAL SCIENCE

Regulation of cell protrusions by small GTPases during fusion of the neural folds

(2016) Ana Rolo et al.   eLife

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Role of the planar cell polarity geneProtein tyrosine kinase 7in neural tube defects in humans

(2015) Mingqin Wang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Rare LRP6 Variants Identified in Spina Bifida Patients

(2015) Yunping Lei et al.   HUMAN MUTATION

Loss-of-function de novo mutations play an important role in severe human neural tube defects

(2015) Philippe Lemay et al.   JOURNAL OF MEDICAL GENETICS

Role of the planar cell polarity geneProtein tyrosine kinase 7in neural tube defects in humans

(2015) Mingqin Wang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure

(2015) E. M. McGreevy et al.   Biology Open

Expanding the mutational spectrum associated to neural tube defects: Literature revision and description of novelVANGL1mutations

(2014) E. Merello et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Genetic studies ofANKRD6as a molecular switch between Wnt signaling pathways in human neural tube defects

(2014) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

(2014) J. N. Murdoch et al.   Disease Models & Mechanisms

Insight into planar cell polarity

(2014) Michael Sebbagh et al.   EXPERIMENTAL CELL RESEARCH

Association between VANGL1 Gene Polymorphisms and Neural Tube Defects

(2014) Baoxing Chang et al.   NEUROPEDIATRICS

Rewiring cell polarity signaling in cancer

(2014) R Halaoui et al.   ONCOGENE

Identification of Novel CELSR1 Mutations in Spina Bifida

(2014) Yunping Lei et al.   PLoS One

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease

(2014) Madeline Hayes et al.   Nature Communications

PTK7 modulates Wnt signaling activity via LRP6

(2013) N. Bin-Nun et al.   DEVELOPMENT

Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/ -catenin-dependent cell fate decisions during vertebrate development

(2013) M. Hayes et al.   DEVELOPMENT

Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway

(2013) Redouane Allache et al.   HUMAN MOLECULAR GENETICS

Neural tube defects: recent advances, unsolved questions, and controversies

(2013) Andrew J Copp et al.   LANCET NEUROLOGY

Mutations in Planar Cell Polarity Gene SCRIB Are Associated with Spina Bifida

(2013) Yunping Lei et al.   PLoS One

Morphogenetic movements in the neural plate and neural tube: mouse

(2013) R'ada Massarwa et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

(2012) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects

(2012) Diana M. Juriloff et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Epithelial fusion during neural tube morphogenesis

(2012) Yun-Jin Pai et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Convergent extension: using collective cell migration and cell intercalation to shape embryos

(2012) M. Tada et al.   DEVELOPMENT

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling

(2012) Maria L. Macheda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Analysis of Disheveled 2 and Disheveled 3 in Human Neural Tube Defects

(2012) Patrizia De Marco et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

De novo mutations in human genetic disease

(2012) Joris A. Veltman et al.   NATURE REVIEWS GENETICS

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion

(2011) Christina Pyrgaki et al.   DEVELOPMENTAL BIOLOGY

PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling

(2011) Hanna Peradziryi et al.   EMBO JOURNAL

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

FZD6is a novel gene for human neural tube defects

(2011) Patrizia De Marco et al.   HUMAN MUTATION

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Identification and characterization of novel rare mutations in the planar cell polarity genePRICKLE1in human neural tube defects

(2011) Ciprian M. Bosoi et al.   HUMAN MUTATION

Planar cell polarity in Drosophila

(2011) Saw Myat Thanda W. Maung et al.   Organogenesis

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure

(2010) Muriel J. Harris et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Contribution of VANGL2 mutations to isolated neural tube defects

(2010) Z Kibar et al.   CLINICAL GENETICS

Zebrafish Neural Tube Morphogenesis Requires Scribble-Dependent Oriented Cell Divisions

(2010) Mihaela Žigman et al.   CURRENT BIOLOGY

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling

(2010) Francesca Puppo et al.   EMBO REPORTS

VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish

(2010) Annie Reynolds et al.   MECHANISMS OF DEVELOPMENT

VANGL2Mutations in Human Cranial Neural-Tube Defects

(2010) Yun-Ping Lei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apical constriction: A cell shape change that can drive morphogenesis

(2009) Jacob M. Sawyer et al.   DEVELOPMENTAL BIOLOGY

Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases

(2009) Yasuhiro Minami et al.   DEVELOPMENTAL DYNAMICS

Novel mutations inVANGL1in neural tube defects

(2009) Zoha Kibar et al.   HUMAN MUTATION

EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion

(2009) Noraishah M. Abdul-Aziz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway

(2009) Isabelle Roszko et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic Basis of Neural Tube Defects

(2009) Alexander G. Bassuk et al.   Seminars in Pediatric Neurology

Planar Cell Polarity Signaling: The Developing Cell's Compass

(2009) E. K. Vladar et al.   Cold Spring Harbor Perspectives in Biology

Planar Cell Polarity: Keeping Hairs Straight Is Not So Simple

(2009) H. McNeill   Cold Spring Harbor Perspectives in Biology

Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States

(2008) B. S. Mosley et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo

(2008) Vitezslav Bryja et al.   MOLECULAR BIOLOGY OF THE CELL

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

(2008) S. Leah Etheridge et al.   PLoS Genetics

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES