The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly

tRNA Maturation Defects Lead to Inhibition of rRNA Processing via Synthesis of pppGpp

(2019) Aude Trinquier et al.   MOLECULAR CELL

Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state

(2019) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide effects on Escherichia coli transcription from ppGpp binding to its two sites on RNA polymerase

(2019) Patricia Sanchez-Vazquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional investigation of the Small Ribosomal Subunit Biogenesis GTP ase A (RsgA) from Pseudomonas aeruginosa

(2019) Serena Rocchio et al.   FEBS Journal

Role of Era in assembly and homeostasis of the ribosomal small subunit

(2019) Aida Razi et al.   NUCLEIC ACIDS RESEARCH

The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus

(2019) Alison Wood et al.   PLoS Genetics

The Hfq chaperone helps the ribosome mature

(2018) Indra Mani Sharma et al.   EMBO JOURNAL

The RNA‐binding protein Hfq is important for ribosome biogenesis and affects translation fidelity

(2018) José M Andrade et al.   EMBO JOURNAL

Elevated levels of Era GTPase improve growth, 16S rRNA processing, and 70S ribosome assembly of Escherichia coli lacking highly conserved multifunctional YbeY endoribonuclease

(2018) Anubrata Ghosal et al.   JOURNAL OF BACTERIOLOGY

The universally conserved GTPase HflX is an RNA helicase that restores heat-damagedEscherichia coliribosomes

(2018) Sandip Dey et al.   JOURNAL OF CELL BIOLOGY

The essential nature of YqfG, a YbeY homologue required for 3′ maturation of Bacillus subtilis 16S ribosomal RNA is suppressed by deletion of RNase R

(2018) Kathrin Baumgardt et al.   NUCLEIC ACIDS RESEARCH

Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli

(2018) Yong Zhang et al.   mBio

Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA

(2018) Patrick Pausch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

(2018) Renuka Kudva et al.   eLife

Structural and biochemical analysis ofEscherichia coliObgE, a central regulator of bacterial persistence

(2017) Sotirios Gkekas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of elusive translational GTPases come to light and inform on the process of ribosome biogenesis in bacteria

(2017) Michelle R. Gibbs et al.   MOLECULAR MICROBIOLOGY

RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket

(2017) Jorge Pedro López-Alonso et al.   NUCLEIC ACIDS RESEARCH

Structure and dynamics of bacterial ribosome biogenesis

(2017) Joseph H. Davis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Disassembly of theStaphylococcus aureushibernating 100S ribosome by an evolutionarily conserved GTPase

(2017) Arnab Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly

(2017) Aida Razi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invited review: Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamily

(2016) Oliver Daumke et al.   BIOPOLYMERS

Review: Translational GTPases

(2016) Cristina Maracci et al.   BIOPOLYMERS

Modular Assembly of the Bacterial Large Ribosomal Subunit

(2016) Joseph H. Davis et al.   CELL

Walker-A Motif Acts to Coordinate ATP Hydrolysis with Motor Output in Viral DNA Packaging

(2016) Damian delToro et al.   JOURNAL OF MOLECULAR BIOLOGY

ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response

(2016) Wilma Ross et al.   MOLECULAR CELL

The magic dance of the alarmones (p)ppGpp

(2016) Wieland Steinchen et al.   MOLECULAR MICROBIOLOGY

Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways

(2016) Jorge P. López-Alonso et al.   NUCLEIC ACIDS RESEARCH

Binding properties of YjeQ (RsgA), RbfA, RimM and Era to assembly intermediates of the 30S subunit

(2016) Brett Thurlow et al.   NUCLEIC ACIDS RESEARCH

The conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome

(2016) Mackenzie L. Coatham et al.   NUCLEIC ACIDS RESEARCH

The stringent response regulates adaptation to darkness in the cyanobacteriumSynechococcus elongatus

(2016) Rachel D. Hood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of YbeY-Protein Interactions Involved in 16S rRNA Maturation and Stress Regulation in Escherichia coli

(2016) Maarten Vercruysse et al.   mBio

Modeling the mechanisms of biological GTP hydrolysis

(2015) Alexandra T.P. Carvalho et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Initiation of mRNA translation in bacteria: structural and dynamic aspects

(2015) Claudio O. Gualerzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

rRNA regulation during growth and under stringent conditions inStaphylococcus aureus

(2015) Benjamin Kästle et al.   ENVIRONMENTAL MICROBIOLOGY

Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

(2015) Yanqing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of BipA in GTP form bound to the ratcheted ribosome

(2015) Veerendra Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

(2015) Wieland Steinchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

(2015) Yanqing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8

(2015) Gang Li et al.   PLoS One

Novel MntR-Independent Mechanism of Manganese Homeostasis in Escherichia coli by the Ribosome-Associated Protein HflX

(2014) G. Kaur et al.   JOURNAL OF BACTERIOLOGY

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

(2014) Stefan Arenz et al.   Nature Communications

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

(2014) Boya Feng et al.   PLOS BIOLOGY

Functional Interaction between Ribosomal Protein L6 and RbgA during Ribosome Assembly

(2014) Megha Gulati et al.   PLoS Genetics

The 100S ribosome: ribosomal hibernation induced by stress

(2014) Hideji Yoshida et al.   Wiley Interdisciplinary Reviews-RNA

Intersection of the stringent response and the CodY regulon in low GC Gram-positive bacteria

(2013) Tobias Geiger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

GTPases involved in bacterial ribosome maturation

(2013) Simon Goto et al.   JOURNAL OF BIOCHEMISTRY

Multiple Exoribonucleases Catalyze Maturation of the 3′ Terminus of 16S Ribosomal RNA (rRNA)

(2013) Shaheen Sulthana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Magic Spot: A ppGpp Binding Site on E. coli RNA Polymerase Responsible for Regulation of Transcription Initiation

(2013) Wilma Ross et al.   MOLECULAR CELL

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex

(2013) Yuhong Zuo et al.   MOLECULAR CELL

Mutational analysis of the ribosome assembly GTPase RbgA provides insight into ribosome interaction and ribosome-stimulated GTPase activation

(2013) Megha Gulati et al.   NUCLEIC ACIDS RESEARCH

Differential regulation by ppGpp versus pppGpp in Escherichia coli

(2013) Undine Mechold et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of a hitherto unknown nucleotide-binding domain and an intricate interdomain regulation in HflX-a ribosome binding GTPase

(2013) Nikhil Jain et al.   NUCLEIC ACIDS RESEARCH

The ribosome modulates the structural dynamics of the conserved GTPase HflX and triggers tight nucleotide binding

(2012) Jeffrey J. Fischer et al.   BIOCHIMIE

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Crystal structure analysis of the translation factor RF3 (release factor 3)

(2012) Kiyohito Kihira et al.   FEBS LETTERS

DEAD-Box RNA Helicases in Bacillus subtilis Have Multiple Functions and Act Independently from Each Other

(2012) M. Lehnik-Habrink et al.   JOURNAL OF BACTERIOLOGY

Structural Insights into Methyltransferase KsgA Function in 30S Ribosomal Subunit Biogenesis

(2012) Daniel Boehringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation

(2012) Asha Ivy Jacob et al.   MOLECULAR CELL

Direct binding targets of the stringent response alarmone (p)ppGpp

(2012) Usheer Kanjee et al.   MOLECULAR MICROBIOLOGY

Binding Mechanism of Metal⋅NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases

(2012) Richard U. Rymer et al.   STRUCTURE

The Stringent Response of Staphylococcus aureus and Its Impact on Survival after Phagocytosis through the Induction of Intracellular PSMs Expression

(2012) Tobias Geiger et al.   PLoS Pathogens

Assembly of Bacterial Ribosomes

(2011) Zahra Shajani et al.   Annual Review of Biochemistry

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

An HflX-Type GTPase from Sulfolobus solfataricus Binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States

(2011) F. Blombach et al.   JOURNAL OF BACTERIOLOGY

The Universally Conserved Prokaryotic GTPases

(2011) N. Verstraeten et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Differential stringent control of Escherichia coli rRNA promoters: effects of ppGpp, DksA and the initiating nucleotides

(2011) T. Kolmsee et al.   MICROBIOLOGY-SGM

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA

(2011) C. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopy

(2011) Qiang Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome-associated GTPases: The role of RNA for GTPase activation

(2011) Nina Clementi et al.   RNA Biology

Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy

(2011) A. Jomaa et al.   RNA

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

RsgA releases RbfA from 30S ribosome during a late stage of ribosome biosynthesis

(2010) Simon Goto et al.   EMBO JOURNAL

Direct Targets of CodY in Staphylococcus aureus

(2010) C. D. Majerczyk et al.   JOURNAL OF BACTERIOLOGY

Thermodynamic Characterization of ppGpp Binding to EF-G or IF2 and of Initiator tRNA Binding to Free IF2 in the Presence of GDP, GTP, or ppGpp

(2010) Vladimir A. Mitkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Discretely calibrated regulatory loops controlled by ppGpp partition gene induction across the ‘feast to famine’ gradient in Escherichia coli

(2010) Matthew F. Traxler et al.   MOLECULAR MICROBIOLOGY

Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing

(2010) Bryan W. Davies et al.   MOLECULAR MICROBIOLOGY

Appropriate maturation and folding of 16S rRNA during 30S subunit biogenesis are critical for translational fidelity

(2010) B. Roy-Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism for Activation of GTP Hydrolysis on the Ribosome

(2010) R. M. Voorhees et al.   SCIENCE

Role of GTPases in Bacterial Ribosome Assembly

(2009) Robert A. Britton   Annual Review of Microbiology

The Molecular Alarmone (p)ppGpp Mediates Stress Responses, Vancomycin Tolerance, and Virulence in Enterococcus faecalis

(2009) J. Abranches et al.   JOURNAL OF BACTERIOLOGY

Properties of HflX, an Enigmatic Protein from Escherichia coli

(2009) D. Dutta et al.   JOURNAL OF BACTERIOLOGY

The ObgE/CgtA GTPase influences the stringent response to amino acid starvation inEscherichia coli

(2009) Nicole S. Persky et al.   MOLECULAR MICROBIOLOGY

ppGpp inhibits the activity of Escherichia coli DnaG primase

(2009) Monika Maciąg et al.   PLASMID

Structure of ERA in complex with the 3' end of 16S rRNA: Implications for ribosome biogenesis

(2009) C. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation of ribosome degradation during starvation in Escherichia coli

(2009) M. A. Zundel et al.   RNA

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides

(2008) Nikhil Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosome Collisions and Translation Efficiency: Optimization by Codon Usage and mRNA Destabilization

(2008) Namiko Mitarai et al.   JOURNAL OF MOLECULAR BIOLOGY

Fine structure of the promoter-  region 1.2 interaction

(2008) S. P. Haugen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a translation termination complex formed with release factor RF2

(2008) A. Korostelev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of YlqF, a circularly permuted GTPase: Implications for its GTPase activation in 50 S ribosomal subunit assembly

(2008) Do Jin Kim et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS