Exosomes: Versatile Nano Mediators of Immune Regulation

Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma

(2019) Nykia D. Walker et al.   Cell Death & Disease

Personalized medicine and back ‐ allogeneic exosomes for cancer immunotherapy

(2019) Monisha Samuel et al.   JOURNAL OF INTERNAL MEDICINE

CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides

(2019) Shu-Wei Wu et al.   Frontiers in Immunology

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

(2018) Simona Anticoli et al.   Biotechnology Journal

Inorganic nanoparticles: A potential cancer therapy for human welfare

(2018) Arivalagan Pugazhendhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

(2018) Xiaochen Wang et al.   JOURNAL OF MEDICAL GENETICS

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

(2018) Simona Anticoli et al.   Biotechnology Journal

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

(2017) Zhen Lu et al.   JOURNAL OF HEPATOLOGY

Role of Lymphocyte Subsets in the Immune Response to Primary B Cell–Derived Exosomes

(2017) Sarah C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

NK Cell–derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells

(2017) Alireza Shoae-Hassani et al.   JOURNAL OF IMMUNOTHERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7

(2017) Gao Wei et al.   Scientific Reports

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells

(2017) Lei Li et al.   Scientific Reports

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

(2016) Kae M. Pusic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells

(2016) Norina Tang et al.   FASEB JOURNAL

Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex

(2016) Sang-Ho Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosisviamembrane TNF-α mediated NF-κB pathway

(2016) Wei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction

(2016) Haibo Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

(2016) Xiao-Li Li et al.   Journal of Neuroinflammation

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

(2016) Subhrajit Saha et al.   Nature Communications

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes

(2016) Stefanie Hiltbrunner et al.   Oncotarget

Exosome-mediated small RNA delivery for gene therapy

(2016) Yu Zhou et al.   Wiley Interdisciplinary Reviews-RNA

Exosomes in cancer: small particle, big player

(2015) Xu Zhang et al.   Journal of Hematology & Oncology

Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response Against Intracranial Glioma in Mice

(2015) Ning Bu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Exosomes: Novel Biomarkers for Clinical Diagnosis

(2015) Jin Lin et al.   TheScientificWorldJOURNAL

Exosomes: Novel Biomarkers for Clinical Diagnosis

(2015) Jin Lin et al.   Scientific World Journal

Killer B Lymphocytes and Their Fas Ligand Positive Exosomes as Inducers of Immune Tolerance

(2015) Steven K. Lundy et al.   Frontiers in Immunology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells

(2014) Andrea Sobo-Vujanovic et al.   CELLULAR IMMUNOLOGY

Experimental immunology Umbilical cord blood-derived dendritic cells loaded with BGC823 tumor antigens and DC-derived exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumor immunity in vitro and in vivo

(2014) Shasha Guan et al.   Central European Journal of Immunology

Induction of Exosome Release in Primary B Cells Stimulated via CD40 and the IL-4 Receptor

(2014) S. C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

Thymus Exosomes-Like Particles Induce Regulatory T Cells

(2014) G.-J. Wang et al.   JOURNAL OF IMMUNOLOGY

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

(2014) Sukhbir Kaur et al.   MATRIX BIOLOGY

Harnessing the exosome-induced immune response for cancer immunotherapy

(2014) Ulf Gehrmann et al.   SEMINARS IN CANCER BIOLOGY

Human B Cell-Derived Lymphoblastoid Cell Lines Constitutively Produce Fas Ligand and Secrete MHCII+FasL+ Killer Exosomes

(2014) Matthew W. Klinker et al.   Frontiers in Immunology

Natural CD8+25+ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma

(2013) Yufeng Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes

(2013) Ulf Gehrmann et al.   CANCER RESEARCH

CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model

(2013) Xuesong Yu et al.   CELLULAR IMMUNOLOGY

Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction

(2013) Lei Yu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

(2013) Aya D. Pusic et al.   JOURNAL OF NEUROIMMUNOLOGY

Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells

(2013) Karin Ekström et al.   PLoS One

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

(2013) Joanna Baginska et al.   Frontiers in Immunology

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Functional transfer of microRNA by exosomes

(2012) W. Stoorvogel   BLOOD

Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells

(2012) Chin Y. Soo et al.   IMMUNOLOGY

Immature Dendritic Cell-Derived Exosomes: a Promise Subcellular Vaccine for Autoimmunity

(2012) Weifan Yin et al.   INFLAMMATION

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

(2012) Xiao Li et al.   PLoS One

Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling

(2012) Jessica Wahlgren et al.   PLoS One

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

(2012) Stephan Munich et al.   OncoImmunology

Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

(2011) R. B. Rountree et al.   CANCER RESEARCH

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

(2011) R Alonso et al.   CELL DEATH AND DIFFERENTIATION

CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity

(2011) Haifeng Zhang et al.   Cellular & Molecular Immunology

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

TGF-β1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4+Foxp3+ regulatory T cells

(2010) Zhijian Cai et al.   Cellular & Molecular Immunology

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn

(2010) Esther Zumaquero et al.   EXPERIMENTAL CELL RESEARCH

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

(2010) Julia Esser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

(2010) Sophie Viaud et al.   JOURNAL OF IMMUNOTHERAPY

Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats

(2010) Xiaojun Yang et al.   JOURNAL OF SURGICAL RESEARCH

The endocytic matrix

(2010) Giorgio Scita et al.   NATURE

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes forin vivofunction

(2009) Melanie A. Ruffner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

(2009) Sophie Viaud et al.   PLoS One

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

B cell activation regulates exosomal HLA production

(2008) Shuji Arita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity☆

(2008) Krisztián Papp et al.   MOLECULAR IMMUNOLOGY

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

(2008) Venkateswara Rao Simhadri et al.   PLoS One

Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells

(2008) Tal Tamari et al.   THROMBOSIS AND HAEMOSTASIS