The Role of Tumor Microenvironment in Genomic Instability of Malignant Tumors

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

(2018) Pernilla Roswall et al.   NATURE MEDICINE

DNA Damage, Repair, and Cancer Metabolism

(2018) Marc-Olivier Turgeon et al.   Frontiers in Oncology

Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

(2018) Subodh Kumar et al.   Blood Cancer Journal

Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis

(2018) Paulo A. Gameiro et al.   Cell Reports

Nucleotide excision repair is a potential therapeutic target in multiple myeloma

(2017) R Szalat et al.   LEUKEMIA

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

(2017) Hui-Ting Lee et al.   NUCLEIC ACIDS RESEARCH

High somatic mutation and neoantigen burden are correlated with decreased progression-free survival in multiple myeloma

(2017) A Miller et al.   Blood Cancer Journal

Tumour microenvironment factors shaping the cancer metabolism landscape

(2016) Dimitrios Anastasiou   BRITISH JOURNAL OF CANCER

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

(2016) Vyom Sharma et al.   Oncotarget

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

(2015) Abigail Hielscher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Interpretation of cytogenetic results in multiple myeloma for clinical practice

(2015) A M Rajan et al.   Blood Cancer Journal

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

(2015) F. Cottini et al.   Cancer Discovery

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

(2014) Aurélie Morin et al.   INTERNATIONAL JOURNAL OF CANCER

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

(2014) Yusaku Nakabeppu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma

(2014) M Affer et al.   LEUKEMIA

Tumor and the Microenvironment: A Chance to Reframe the Paradigm of Carcinogenesis?

(2014) Mariano Bizzarri et al.   Biomed Research International

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines

(2013) N. P. Degtyareva et al.   NUCLEIC ACIDS RESEARCH

Microenvironment Promotes Tumor Cell Reprogramming in Human Breast Cancer Cell Lines

(2013) Fabrizio D’Anselmi et al.   PLoS One

Genomic Instability in Cancer

(2013) T. Abbas et al.   Cold Spring Harbor Perspectives in Biology

Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma

(2012) S. Koduru et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Genomics in Multiple Myeloma

(2011) Nikhil C. Munshi et al.   CLINICAL CANCER RESEARCH

A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial

(2011) K D Boyd et al.   LEUKEMIA

Gender and ploidy in cancer survival

(2011) Susanne Schulze et al.   CELLULAR ONCOLOGY

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients

(2010) Yanran Cao et al.   EXPERIMENTAL HEMATOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer

(2009) O. Dakhova et al.   CLINICAL CANCER RESEARCH

Tumor Hypoxia as a Modifier of DNA Strand Break and Cross-Link Repair

(2009) Norman Chan et al.   CURRENT MOLECULAR MEDICINE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Dysfunctional homologous recombination mediates genomic instability and progression in myeloma

(2008) M. A. Shammas et al.   BLOOD

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2

(2008) H Nakamura et al.   ONCOGENE

Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells

(2008) Francisco Javier Rodríguez-Jiménez et al.   STEM CELLS