Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
Authors
Keywords
-
Journal
LEUKEMIA
Volume 28, Issue 8, Pages 1725-1735
Publisher
Springer Nature
Online
2014-02-12
DOI
10.1038/leu.2014.70
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells
- (2013) B. A. Walker et al. BLOOD
- Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes
- (2013) Lixing Yang et al. CELL
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Super-Enhancers in the Control of Cell Identity and Disease
- (2013) Denes Hnisz et al. CELL
- Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
- (2013) S. C. J. Parker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC addiction: a potential therapeutic target in MM
- (2012) W. M. Kuehl et al. BLOOD
- Addiction to c-MYC in multiple myeloma
- (2012) T. Holien et al. BLOOD
- Frequent PVT1 Rearrangement and Novel Chimeric Genes PVT1-NBEA and PVT1-WWOX Occur in Multiple Myeloma with 8q24 Abnormality
- (2012) H. Nagoshi et al. CANCER RESEARCH
- Molecular pathogenesis of multiple myeloma and its premalignant precursor
- (2012) W. Michael Kuehl et al. JOURNAL OF CLINICAL INVESTIGATION
- Germline Deletion of Igh 3' Regulatory Region Elements hs 5, 6, 7 (hs5-7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus
- (2012) S. A. Volpi et al. JOURNAL OF IMMUNOLOGY
- The role of CTCF binding sites in the 3′ immunoglobulin heavy chain regulatory region
- (2012) Barbara K. Birshtein Frontiers in Genetics
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Mapping of Chromosome 1p Deletions in Myeloma Identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as Being Genes in Regions Associated with Adverse Survival
- (2011) K. D. Boyd et al. CLINICAL CANCER RESEARCH
- Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma
- (2011) W-J Chng et al. LEUKEMIA
- Initial genome sequencing and analysis of multiple myeloma
- (2011) Michael A. Chapman et al. NATURE
- Mapping and analysis of chromatin state dynamics in nine human cell types
- (2011) Jason Ernst et al. NATURE
- Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma
- (2010) D. Hose et al. HAEMATOLOGICA
- Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management
- (2010) R A Kyle et al. LEUKEMIA
- Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells
- (2009) Ernesto Pérez-Persona et al. BRITISH JOURNAL OF HAEMATOLOGY
- Frequent upregulation ofMYCin plasma cell leukemia
- (2009) Laura Chiecchio et al. GENES CHROMOSOMES & CANCER
- Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
- (2009) L. Chiecchio et al. HAEMATOLOGICA
- AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies
- (2008) Marta Chesi et al. CANCER CELL
- Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors
- (2008) Ana Gabrea et al. GENES CHROMOSOMES & CANCER
- Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma
- (2007) A. Dispenzieri et al. BLOOD
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started