Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages

(2018) Chien wen Su et al.   Scientific Reports

Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy

(2017) Ruby L. C. Hoo et al.   Scientific Reports

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

(2016) Valerie A. Gerriets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

(2016) Afiat Berbudi et al.   Journal of Innate Immunity

Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b+ macrophages

(2016) Anna A. De Boer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

(2016) J. Surendar et al.   PARASITE IMMUNOLOGY

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

(2015) L. Guo et al.   BLOOD

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes

(2015) Afiat Berbudi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

(2015) Leonie Hussaarts et al.   FASEB JOURNAL

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

(2015) L Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

(2015) Stephanie Flaherty et al.   Jove-Journal of Visualized Experiments

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

(2014) Tracey McLaughlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

ST2 Deficiency Does Not Impair Type 2 Immune Responses during Chronic Filarial Infection but Leads to an Increased Microfilaremia Due to an Impaired Splenic Microfilarial Clearance

(2014) Jesuthas Ajendra et al.   PLoS One

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

Fatty Acids, Lipid Mediators, and T-Cell Function

(2014) Anja J. de Jong et al.   Frontiers in Immunology

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Adipocyte-derived lipids modulate CD4+T-cell function

(2013) Andreea Ioan-Facsinay et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity

(2013) D. C. Saucillo et al.   JOURNAL OF IMMUNOLOGY

Role of Adipokines Signaling in the Modulation of T Cells Function

(2013) Claudio Procaccini et al.   Frontiers in Immunology

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

(2012) K. van der Weerd et al.   DIABETES

Adiponectin Induces Pro-inflammatory Programs in Human Macrophages and CD4+T Cells

(2012) Xiang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China

(2012) Yuhong Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Innate immune activation in obesity

(2012) Carey N. Lumeng   MOLECULAR ASPECTS OF MEDICINE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

(2011) I. R. Klein-Wieringa et al.   ANNALS OF THE RHEUMATIC DISEASES

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

(2011) Kees Meijer et al.   PLoS One

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

(2011) Bin Feng et al.   PLoS One

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway

(2010) M. Galgani et al.   JOURNAL OF IMMUNOLOGY

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

(2010) Vivekanandhan Aravindhan et al.   PLoS Neglected Tropical Diseases

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

T-lymphocyte Infiltration in Visceral Adipose Tissue

(2008) Ulrich Kintscher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+regulatory T cells

(2008) Marc P. Hübner et al.   IMMUNOLOGY

Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in Atherogenesis

(2007) Yoshihisa Okamoto et al.   CIRCULATION RESEARCH