LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System

Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance

(2018) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

(2018) Miroslav Hons et al.   NATURE IMMUNOLOGY

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

(2017) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

Stromal Cell Niches in the Inflamed Central Nervous System

(2017) Natalia B. Pikor et al.   JOURNAL OF IMMUNOLOGY

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation

(2015) M. Paterka et al.   EMBO JOURNAL

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

Multiple Sclerosis and T Lymphocytes: An Entangled Story

(2015) Laurine Legroux et al.   Journal of Neuroimmune Pharmacology

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Quantifying Modes of 3D Cell Migration

(2015) Meghan K. Driscoll et al.   TRENDS IN CELL BIOLOGY

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

(2014) Pericles Calias et al.   PHARMACOLOGY & THERAPEUTICS

Plasticity of Human CD4 T Cell Subsets

(2014) Jens Geginat et al.   Frontiers in Immunology

Integrin modulators: a patent review

(2013) Tobias G Kapp et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Use of imaging to study leukocyte trafficking in the central nervous system

(2013) Elena Zenaro et al.   IMMUNOLOGY AND CELL BIOLOGY

2-photon imaging of phagocyte-mediated T cell activation in the CNS

(2013) Marija Pesic et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1

(2013) T. Katakai et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Suppress the Late Phase of the Immune Response in Lymph Nodes through P-Selectin Glycoprotein Ligand-1

(2013) S. Angiari et al.   JOURNAL OF IMMUNOLOGY

Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination

(2013) Abdolmohamad Rostami et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator

(2013) Marsilius Mues et al.   NATURE MEDICINE

Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response

(2012) Stefanie Kuerten et al.   ACTA NEUROPATHOLOGICA

Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity

(2012) Robert C. Axtell et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrins as receptor targets for neurological disorders

(2012) Xin Wu et al.   PHARMACOLOGY & THERAPEUTICS

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Immunopathogenesis of multiple sclerosis

(2011) Manuel Comabella et al.   CLINICAL IMMUNOLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells

(2010) Hema Mohan et al.   BRAIN PATHOLOGY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Mechanical modes of ‘amoeboid’ cell migration

(2009) Tim Lämmermann et al.   CURRENT OPINION IN CELL BIOLOGY

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites

(2009) Jiyun V. Kim et al.   JOURNAL OF IMMUNOLOGICAL METHODS

α4-Integrin antagonism with natalizumab

(2009) Olaf Stüve et al.   JOURNAL OF NEUROLOGY

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis

(2008) E Butti et al.   GENE THERAPY

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

(2008) Jiyun V. Kim et al.   NATURE

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy

(2007) Dimitrios Davalos et al.   JOURNAL OF NEUROSCIENCE METHODS