Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer

CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics

(2019) Debarati Ghosh et al.   Cancer Cell International

GATA6: a new predictor for prognosis in ovarian Cancer

(2019) Weiwei Shen et al.   HUMAN PATHOLOGY

The Diverse Consequences of FOXC1 Deregulation in Cancer

(2019) L. Niall Gilding et al.   Cancers

GATA5 inhibits hepatocellular carcinoma cells malignant behaviours by blocking expression of reprogramming genes

(2019) Haipeng Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MYC modulators in cancer: a patent review

(2019) Xiao-Na Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

(2019) Lei Gao et al.   Nature Communications

Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development

(2018) Shen-Ju Chou et al.   BRAIN RESEARCH

bHLH transcription factors in neural development, disease, and reprogramming

(2018) Daniel J. Dennis et al.   BRAIN RESEARCH

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

(2018) Stephen Safe et al.   Cancer Prevention Research

Pathogenic Germline Variants in 10,389 Adult Cancers

(2018) Kuan-lin Huang et al.   CELL

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

CRISPR therapeutic tools for complex genetic disorders and cancer (Review)

(2018) Stella Baliou et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Epithelial-to-Mesenchymal Transition in Cancer

(2018) Joëlle Roche   Cancers

GATA4 inhibits cell differentiation and proliferation in pancreatic cancer

(2018) Yan Gong et al.   PLoS One

A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage

(2018) Juan Manuel Vazquez et al.   Cell Reports

Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

(2018) Sonali Bhattacharjee et al.   Cancers

GATA transcription factors in development and disease

(2018) Mathieu Tremblay et al.   DEVELOPMENT

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

(2018) Lavinia Carabet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic myelomonocytic leukemia treated with 5-azacytidine – results from the Hellenic 5-Azacytidine Registry: proposal of a new risk stratification system

(2018) Panagiotis T. Diamantopoulos et al.   LEUKEMIA & LYMPHOMA

Upregulation of Fibroblast Growth Factors Caused by Heart and Neural Crest Derivatives Expressed 2 Suppression in Endometriotic Cells: A Possible Therapeutic Target in Endometriosis

(2018) Nao Kato et al.   Reproductive Sciences

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

(2018) Ari Loren Mendell et al.   Frontiers in Molecular Neuroscience

Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23

(2018) Natalina Quarto et al.   Frontiers in Physiology

Essential roles of Tbx3 in embryonic skin development during epidermal stratification

(2017) Ryo Ichijo et al.   GENES TO CELLS

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

(2017) Sonali Bhattacharjee et al.   IUBMB LIFE

Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins

(2017) Shabana Khan et al.   JOURNAL OF NEUROSCIENCE

Impact of Detergents on Membrane Protein Complex Isolation

(2017) Yu-Chen Lee et al.   JOURNAL OF PROTEOME RESEARCH

The Unique immunologic and microbial aspects of pregnancy

(2017) Gil Mor   PLACENTA

Molecular signatures of longevity: Insights from cross-species comparative studies

(2017) Siming Ma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

(2017) Heather C. Bruner et al.   Cold Spring Harbor Perspectives in Biology

A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer

(2017) Nicholas Villarino et al.   Oncotarget

Overexpression of SlPRE2, an atypical bHLH transcription factor, affects plant morphology and fruit pigment accumulation in tomato

(2017) Zhiguo Zhu et al.   Scientific Reports

Fox transcription factors: from development to disease

(2016) Maria L. Golson et al.   DEVELOPMENT

The emerging role of GATA transcription factors in development and disease

(2016) Marjolein HFM Lentjes et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

(2016) Paola Martinelli et al.   GUT

DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells

(2016) Tomoko Sasamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role and functioning of bHLH transcription factors in jasmonate signalling

(2016) Jonas Goossens et al.   JOURNAL OF EXPERIMENTAL BOTANY

CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations

(2016) Alexis Guernet et al.   MOLECULAR CELL

The role of GATA2 in lethal prostate cancer aggressiveness

(2016) Veronica Rodriguez-Bravo et al.   Nature Reviews Urology

Changes in the enhancer landscape during early placental development uncover a trophoblast invasion gene-enhancer network

(2016) Geetu Tuteja et al.   PLACENTA

Evolution of Plasticity: Mechanistic Link between Development and Reversible Acclimation

(2016) Julian E. Beaman et al.   TRENDS IN ECOLOGY & EVOLUTION

How elephants beat cancer

(2016) Stephen J Gaughran et al.   eLife

The emerging roles of Oct4 in tumor-initiating cells

(2015) Ying-Jie Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Cellular Identity in Cancer

(2015) Nilotpal Roy et al.   DEVELOPMENTAL CELL

An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors

(2015) Andrew T. Chang et al.   GENES & DEVELOPMENT

Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans

(2015) Lisa M. Abegglen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth

(2015) Inan Olmez et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

(2015) Cheryl M. Koh et al.   JOURNAL OF CLINICAL INVESTIGATION

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

(2015) Lauren R Polstein et al.   Nature Chemical Biology

TET1 is a tumor suppressor of hematopoietic malignancy

(2015) Luisa Cimmino et al.   NATURE IMMUNOLOGY

Modeling the relationship of epigenetic modifications to transcription factor binding

(2015) Liang Liu et al.   NUCLEIC ACIDS RESEARCH

Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells

(2015) Itaru Imayoshi et al.   Frontiers in Cellular Neuroscience

Acute loss of TET function results in aggressive myeloid cancer in mice

(2015) Jungeun An et al.   Nature Communications

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance

(2015) Altamira Arce-Cerezo et al.   Scientific Reports

Insights into the Evolution of Longevity from the Bowhead Whale Genome

(2015) Michael Keane et al.   Cell Reports

Expression of Connective Tissue Growth Factor in Male Breast Cancer: Clinicopathologic Correlations and Prognostic Value

(2015) Miangela M. Lacle et al.   PLoS One

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Molecular Pathways: Targeting ETS Gene Fusions in Cancer

(2014) F. Y. Feng et al.   CLINICAL CANCER RESEARCH

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

(2014) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Traversing the basement membrane in vivo: A diversity of strategies

(2014) Laura C. Kelley et al.   JOURNAL OF CELL BIOLOGY

Hey1 and Hey2 Control the Spatial and Temporal Pattern of Mammalian Auditory Hair Cell Differentiation Downstream of Hedgehog Signaling

(2014) A. Benito-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin

(2014) Z Liu et al.   ONCOGENE

Sodium salicylate switches glucose depletion-induced necrosis to autophagy and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells

(2014) Sung-Chul Lim et al.   ONCOLOGY REPORTS

Cyclin D2 is a GATA4 cofactor in cardiogenesis

(2014) A. Yamak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

A new twist to the GATA switch

(2013) S. Philipsen   BLOOD

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

(2013) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Small Molecule Inhibition of PAX3-FOXO1 through AKT Activation Suppresses Malignant Phenotypes of Alveolar Rhabdomyosarcoma

(2013) M. Jothi et al.   MOLECULAR CANCER THERAPEUTICS

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression

(2013) Jonathan Chou et al.   NATURE CELL BIOLOGY

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

(2013) Catherine Frelin et al.   NATURE IMMUNOLOGY

Heritable genome editing in C. elegans via a CRISPR-Cas9 system

(2013) Ari E Friedland et al.   NATURE METHODS

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells

(2013) Sandeep N. Shah et al.   PLoS One

Evolutionary History of Chordate PAX Genes: Dynamics of Change in a Complex Gene Family

(2013) Vanessa Rodrigues Paixão-Côrtes et al.   PLoS One

Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells

(2013) Ariel B Abraham et al.   Proteome Science

Identification of a Developmental Gene Expression Signature, Including HOX Genes, for the Normal Human Colonic Crypt Stem Cell Niche: Overexpression of the Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis

(2013) Seema Bhatlekar et al.   STEM CELLS AND DEVELOPMENT

Control of Vertebrate Development by MYC

(2013) P. J. Hurlin   Cold Spring Harbor Perspectives in Medicine

Pluripotency transcription factors and cancer stem cells: small genes make a big difference

(2013) Anfei Liu et al.   Chinese Journal of Cancer

Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis

(2012) Divya Patel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drugging the undruggable: Transcription therapy for cancer

(2012) Chunhong Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

(2012) Madhu S. Kumar et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Signaling from the Sympathetic Nervous System Regulates Hematopoietic Stem Cell Emergence during Embryogenesis

(2012) Simon R. Fitch et al.   Cell Stem Cell

Wnt Signaling Regulates Postembryonic Hypothalamic Progenitor Differentiation

(2012) Xu Wang et al.   DEVELOPMENTAL CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function

(2012) Sung-Uk Lee et al.   IMMUNOLOGICAL REVIEWS

The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer

(2012) YUNYAN WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells

(2012) Aurelie Borrull et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group

(2012) Verena I. Gaidzik et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer and Pregnancy: Parallels in Growth, Invasion, and Immune Modulation and Implications for Cancer Therapeutic Agents

(2012) Shernan G. Holtan et al.   MAYO CLINIC PROCEEDINGS

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

(2012) S M Kumar et al.   ONCOGENE

Human mortality improvement in evolutionary context

(2012) O. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development

(2012) Ruben Gutzat et al.   TRENDS IN PLANT SCIENCE

PAX Genes in Cancer; Friends or Foes?

(2012) Caiyun G. Li et al.   Frontiers in Genetics

The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma

(2011) Kai Doberstein et al.   CARCINOGENESIS

Hand2 Loss-of-Function in Hand1 -Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development

(2011) Ralston M. Barnes et al.   CIRCULATION RESEARCH

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis

(2011) F. Ali et al.   DEVELOPMENT

GATA5 interacts with GATA4 and GATA6 in outflow tract development

(2011) Brigitte Laforest et al.   DEVELOPMENTAL BIOLOGY

HMGB factors are required for posterior digit development through integrating signaling pathway activities

(2011) Junji Itou et al.   DEVELOPMENTAL DYNAMICS

Minireview: Intrinsic and Extrinsic Factors in Thyroid Gland Development: An Update

(2011) Mario De Felice et al.   ENDOCRINOLOGY

GATA Factors Regulate Proliferation, Differentiation, and Gene Expression in Small Intestine of Mature Mice

(2011) Eva Beuling et al.   GASTROENTEROLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1

(2011) Ujjal K Bhawal et al.   JOURNAL OF PATHOLOGY

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Phosphorylation Regulates OLIG2 Cofactor Choice and the Motor Neuron-Oligodendrocyte Fate Switch

(2011) Huiliang Li et al.   NEURON

PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein

(2011) C G Li et al.   ONCOGENE

Hes1 Is Required for Appropriate Morphogenesis and Differentiation during Mouse Thyroid Gland Development

(2011) Aurore Carre et al.   PLoS One

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peto's Paradox: evolution's prescription for cancer prevention

(2011) Aleah F. Caulin et al.   TRENDS IN ECOLOGY & EVOLUTION

Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

(2010) Shigeru Saito et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Developmental function of HMGN proteins

(2010) Takashi Furusawa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma

(2010) Baojin Fu et al.   CANCER BIOLOGY & THERAPY

Steroid hormone receptors in cancer development: A target for cancer therapeutics

(2010) Nihal Ahmad et al.   CANCER LETTERS

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers

(2010) Ja-Lok Ku et al.   CARCINOGENESIS

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Pax6 Is a Human Neuroectoderm Cell Fate Determinant

(2010) Xiaoqing Zhang et al.   Cell Stem Cell

Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate

(2010) Kelli L. VanDussen et al.   DEVELOPMENTAL BIOLOGY

Characterization and In Vivo Pharmacological Rescue of a Wnt2-Gata6 Pathway Required for Cardiac Inflow Tract Development

(2010) Ying Tian et al.   DEVELOPMENTAL CELL

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives

(2010) Ralston M. Barnes et al.   DEVELOPMENTAL DYNAMICS

Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling

(2010) Taeko Kobayashi et al.   GENES TO CELLS

Paired box gene 5is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway

(2010) Weili Liu et al.   HEPATOLOGY

From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation

(2010) Tomonori Hosoya et al.   IMMUNOLOGICAL REVIEWS

Non-syndromic Oligodontia with a Novel Mutation of PAX9

(2010) N. Suda et al.   JOURNAL OF DENTAL RESEARCH

PAX5  Enhances the Epithelial Behavior of Human Mammary Carcinoma Cells

(2010) L. J-P Vidal et al.   MOLECULAR CANCER RESEARCH

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Human FOXP3 and cancer

(2010) F Martin et al.   ONCOGENE

Genome-Wide Classification and Evolutionary Analysis of the bHLH Family of Transcription Factors in Arabidopsis, Poplar, Rice, Moss, and Algae

(2010) L. Carretero-Paulet et al.   PLANT PHYSIOLOGY

Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression

(2010) Jun Liu et al.   PROSTATE

Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo

(2010) Anna Ferrer-Vaquer et al.   Cell Adhesion & Migration

Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

(2009) Lizhong Wang et al.   CANCER CELL

Loss of VHL and Hypoxia Provokes PAX2 Up-Regulation in Clear Cell Renal Cell Carcinoma

(2009) V.-D. Luu et al.   CLINICAL CANCER RESEARCH

Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis

(2009) A. N. Smith et al.   DEVELOPMENT

Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo

(2009) Heidi Bildsoe et al.   DEVELOPMENTAL BIOLOGY

ThePAX258gene subfamily: A comparative perspective

(2009) Debbie K. Goode et al.   DEVELOPMENTAL DYNAMICS

HMGB1 attenuates anti-metastatic defence of the liver in colorectal cancer

(2009) Yi Luo et al.   EUROPEAN JOURNAL OF CANCER

PAX6 Is Expressed in Pancreatic Cancer and Actively Participates in Cancer Progression through Activation of the MET Tyrosine Kinase Receptor Gene

(2009) Joseph B. Mascarenhas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A

(2009) Yi-Hong Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

Is There Such a Thing as a Renal Stem Cell?

(2009) M. H. Little et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study

(2009) Guo-Xia Tong et al.   MODERN PATHOLOGY

Origin and Diversification of Basic-Helix-Loop-Helix Proteins in Plants

(2009) N. Pires et al.   MOLECULAR BIOLOGY AND EVOLUTION

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells

(2009) Carolin Schild et al.   MOLECULAR CARCINOGENESIS

The evolution of Fox genes and their role in development and disease

(2009) Sridhar Hannenhalli et al.   NATURE REVIEWS GENETICS

GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis

(2009) A B Dydensborg et al.   ONCOGENE

217 CHROMATIN PROTEIN HMGB2 REGULATES ARTICULAR CARTILAGE SURFACE MAINTENANCE VIA BETA-CATENIN PATHWAYS

(2009) N. Taniguchi et al.   OSTEOARTHRITIS AND CARTILAGE

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages

(2008) Susan Bassham et al.   BMC BIOLOGY

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model

(2008) Hosein Kouros-Mehr et al.   CANCER CELL

AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies

(2008) Marta Chesi et al.   CANCER CELL

PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma

(2008) Y.-J. Chen et al.   CANCER RESEARCH

Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

(2008) Jacob Hanna et al.   CELL

Pax9mediated cell survival in oral squamous carcinoma cell enhanced byc-myb

(2008) Jung-Chang Lee et al.   CELL BIOCHEMISTRY AND FUNCTION

Thyroid stem cells: lessons from normal development and thyroid cancer

(2008) D. Thomas et al.   ENDOCRINE-RELATED CANCER

Identification of novel DNA methylation markers in cervical cancer

(2008) Hung-Cheng Lai et al.   INTERNATIONAL JOURNAL OF CANCER

Paxgenes in embryogenesis and oncogenesis

(2008) Qiuyu Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The amphioxus genome and the evolution of the chordate karyotype

(2008) Nicholas H. Putnam et al.   NATURE

Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia

(2008) S.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells

(2008) Yaser Atlasi et al.   STEM CELLS