Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine
Authors
Keywords
-
Journal
Translational Psychiatry
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-11-28
DOI
10.1038/s41398-019-0660-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
- (2019) Carl M. Sellgren et al. NATURE NEUROSCIENCE
- iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
- (2019) Peiyan Ni et al. MOLECULAR PSYCHIATRY
- Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study
- (2019) Ragy R. Girgis et al. PSYCHIATRY RESEARCH
- N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study
- (2019) Emeline Mullier et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies
- (2019) Amber Berdenis van Berlekom et al. SCHIZOPHRENIA BULLETIN
- Comparative characterization of human induced pluripotent stem cells (hiPSC) derived from patients with schizophrenia and autism
- (2019) Lena-Marie Grunwald et al. Translational Psychiatry
- PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders
- (2018) Brielle R. Ferguson et al. Frontiers in Neural Circuits
- Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience
- (2018) JP Kesby et al. Translational Psychiatry
- Gephyrin: a key regulatory protein of inhibitory synapses and beyond
- (2018) Femke L. Groeneweg et al. HISTOCHEMISTRY AND CELL BIOLOGY
- mRNA-Based Genetic Reprogramming
- (2018) Luigi Warren et al. MOLECULAR THERAPY
- N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial
- (2018) Paul Klauser et al. Translational Psychiatry
- Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development
- (2018) Donna L. McPhie et al. Translational Psychiatry
- Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder
- (2017) Bradley Watmuff et al. PHARMACOGENOMICS
- N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis
- (2017) Philippe Conus et al. SCHIZOPHRENIA BULLETIN
- Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia
- (2017) D A Maas et al. Translational Psychiatry
- The Neural Cell Adhesion Molecule (NCAM) Promotes Clustering and Activation of EphA3 Receptors in GABAergic Interneurons to Induce Ras Homolog Gene Family, Member A (RhoA)/Rho-associated protein kinase (ROCK)-mediated Growth Cone Collapse
- (2016) Chelsea S. Sullivan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurodevelopmental origins of bipolar disorder: iPSC models
- (2016) K. Sue O'Shea et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells
- (2016) Bradley Watmuff et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Stem cell models of neuropsychiatric disorders
- (2016) Rakesh Karmacharya et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders
- (2016) Mingyan Lin et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement
- (2016) Sang-Young Kim et al. SCHIZOPHRENIA BULLETIN
- Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology?
- (2016) P. Steullet et al. SCHIZOPHRENIA RESEARCH
- Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses
- (2016) Quynh-Anh Nguyen et al. eLife
- Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies
- (2015) Javier Arnedo et al. AMERICAN JOURNAL OF PSYCHIATRY
- Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
- (2015) R. Gao et al. CURRENT MOLECULAR MEDICINE
- 60 years of advances in neuropsychopharmacology for improving brain health, renewed hope for progress
- (2015) Mark J. Millan et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders
- (2015) Mark J. Millan et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia
- (2015) Kim Q. Do et al. SCHIZOPHRENIA BULLETIN
- Schizophrenia: a tale of two critical periods for prefrontal cortical development
- (2015) L D Selemon et al. Translational Psychiatry
- Neuroligins, synapse balance and neuropsychiatric disorders
- (2014) Marzena Maćkowiak et al. Pharmacological Reports
- iPS cell technologies: significance and applications to CNS regeneration and disease
- (2014) Hideyuki Okano et al. Molecular Brain
- Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients
- (2014) H M Chen et al. Translational Psychiatry
- Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
- (2013) Yan Liu et al. Nature Protocols
- Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models
- (2012) Anita Kulak et al. ANTIOXIDANTS & REDOX SIGNALING
- Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia
- (2012) Patricio O’Donnell EUROPEAN JOURNAL OF NEUROSCIENCE
- Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
- (2012) Yichen Shi et al. Nature Protocols
- Losing your inhibition: Linking cortical GABAergic interneurons to schizophrenia
- (2012) Melis Inan et al. NEUROBIOLOGY OF DISEASE
- Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
- (2012) A. Watanabe et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Inhibitory Interneurons, Oxidative Stress, and Schizophrenia
- (2012) E. M. Sullivan et al. SCHIZOPHRENIA BULLETIN
- Oxydative stress alters nuclear shape through lamins dysregulation
- (2012) Aurélia Barascu et al. Nucleus
- Cortical Deficits of Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Clinical, Protein, and Cell Type-Specific Features
- (2011) Allison A. Curley et al. AMERICAN JOURNAL OF PSYCHIATRY
- Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
- (2011) David A. Lewis et al. TRENDS IN NEUROSCIENCES
- Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia
- (2008) Colin Kehrer Frontiers in Molecular Neuroscience
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started