VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage

Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals

(2013) Iria Barcia-Sanjurjo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

(2013) Markku Varjosalo et al.   NATURE METHODS

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

(2013) Il-Jin Kim et al.   Nature Communications

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo

(2013) T P Molitor et al.   Oncogenesis

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage

(2012) Marta Sanz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence

(2012) Yoon Ha Choi et al.   NUCLEIC ACIDS RESEARCH

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1

(2012) Jinkyung Kim et al.   Scientific Reports

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

(2011) Joon Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase

(2011) Wanil Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

(2011) Marta Sanz-García et al.   Journal of Proteomics

The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis

(2011) Carolyn S. Schober et al.   MECHANISMS OF DEVELOPMENT

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

(2011) Alberto Valbuena et al.   PLoS One

Genome-wide analysis of germ cell proliferation in C. elegans identifies VRK-1 as a key regulator of CEP-1/p53

(2010) Katherine Waters et al.   DEVELOPMENTAL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells

(2010) Yoon Ha Choi et al.   PLoS One

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Is Caused by a Mutation in the VRK1 Gene

(2009) Paul Renbaum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mice Deficient in the Serine/Threonine Protein Kinase VRK1 Are Infertile Due to a Progressive Loss of Spermatogonia1

(2009) Matthew S. Wiebe et al.   BIOLOGY OF REPRODUCTION

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities

(2008) Marta Sanz-García et al.   MOLECULAR & CELLULAR PROTEOMICS

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

(2008) Alberto Valbuena et al.   PLoS One