Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

The E3 ligase Itch in immune regulation and beyond

(2015) Daisuke Aki et al.   IMMUNOLOGICAL REVIEWS

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation

(2015) Christopher Riling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the road with WRAP53β: guardian of Cajal bodies and genome integrity

(2015) Sofia Henriksson et al.   Frontiers in Genetics

Autoregulation of the 26S proteasome by in situ ubiquitination

(2014) Andrew D. Jacobson et al.   MOLECULAR BIOLOGY OF THE CELL

Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O

(2014) Nazar Mashtalir et al.   MOLECULAR CELL

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

(2013) Javier H. Jara et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy

(2013) Sara K. Custer et al.   HUMAN MOLECULAR GENETICS

Signals controlling Cajal body assembly and function

(2013) Michael D. Hebert   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein

(2013) Deborah Y. Kwon et al.   MOLECULAR BIOLOGY OF THE CELL

Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy

(2012) Olga Tapia et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-Survival Motor Neuron

(2012) Ke-Jun Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

The COPI vesicle complex binds and moves with survival motor neuron within axons

(2011) Cyril Jayakumar Peter et al.   HUMAN MOLECULAR GENETICS

Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1

(2011) Kenneth Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleolus directly regulates p53 export and degradation

(2011) Mark T. Boyd et al.   JOURNAL OF CELL BIOLOGY

Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage

(2011) Andrew S. Gilder et al.   MOLECULAR BIOLOGY OF THE CELL

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

(2010) Christopher Hooper et al.   BMC BIOLOGY

Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis

(2010) Yingshan Piao et al.   BRAIN RESEARCH

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts

(2010) Shih-Hsien Hsu et al.   CLINICA CHIMICA ACTA

A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity

(2010) S. Cho et al.   GENES & DEVELOPMENT

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

(2010) X. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

(2009) MingFang Tao et al.   CURRENT BIOLOGY

The role of RNP biogenesis in spinal muscular atrophy

(2009) Ashwin Chari et al.   CURRENT OPINION IN CELL BIOLOGY

The HECT Domain of the Ubiquitin Ligase Rsp5 Contributes to Substrate Recognition

(2009) Jacqueline R. E. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

The Cajal body

(2008) Glenn E. Morris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing

(2008) Zhenxi Zhang et al.   CELL

Regulation of SMN Protein Stability

(2008) B. G. Burnett et al.   MOLECULAR AND CELLULAR BIOLOGY

Inactivation of the SMN Complex by Oxidative Stress

(2008) Lili Wan et al.   MOLECULAR CELL