Towards an understanding of regulating Cajal body activity by protein modification

A role for the survival of motor neuron protein in mRNP assembly and transport

(2016) Paul G Donlin-Asp et al.   CURRENT OPINION IN NEUROBIOLOGY

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

(2016) Ke-Jun Han et al.   HUMAN MOLECULAR GENETICS

Cajal bodies are linked to genome conformation

(2016) Qiuyan Wang et al.   Nature Communications

SMN and coilin negatively regulate dyskerin association with telomerase RNA

(2016) Aaron R. Poole et al.   Biology Open

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

(2015) Tamara Ratovitski et al.   CELL CYCLE

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin   to promote nuclear translocation

(2015) S. A. Jeong et al.   JOURNAL OF CELL SCIENCE

The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization

(2015) Alma Husedzinovic et al.   MOLECULAR BIOLOGY OF THE CELL

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

(2015) Dorothy Yanling Zhao et al.   NATURE

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

(2015) Karoline B Kuchenbaecker et al.   NATURE GENETICS

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle

(2015) Lara Cantarero et al.   Scientific Reports

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

(2015) Duy Nguyen et al.   Cell Reports

SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

(2015) Ivan Novotný et al.   Cell Reports

Deletion of Drosophila Nopp140 induces subcellular ribosomopathies

(2014) Fang He et al.   CHROMOSOMA

Phosphoregulation of the human SMN complex

(2014) Alma Husedzinovic et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair

(2014) Sofia Henriksson et al.   GENES & DEVELOPMENT

The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis

(2014) O. Tapia et al.   JOURNAL OF CELL SCIENCE

Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability

(2014) Y. Li et al.   JOURNAL OF CELL SCIENCE

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II

(2014) S. Hutten et al.   JOURNAL OF CELL SCIENCE

Label-Free Quantitative Proteomic Profiling Identifies Disruption of Ubiquitin Homeostasis As a Key Driver of Schwann Cell Defects in Spinal Muscular Atrophy

(2014) Arwin Aghamaleky Sarvestany et al.   JOURNAL OF PROTEOME RESEARCH

The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies

(2014) Martin Machyna et al.   MOLECULAR CELL

Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target

(2014) Rachael A. Powis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Targeting vertebrate intron-encoded box C/D 2′-O-methylation guide RNAs into the Cajal body

(2014) Aline Marnef et al.   NUCLEIC ACIDS RESEARCH

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis

(2014) Martina Magni et al.   NUCLEIC ACIDS RESEARCH

Validity of Acute Stroke Lesion Volume Estimation by Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomographic Score Depends on Lesion Location in 496 Patients With Middle Cerebral Artery Stroke

(2014) Julian Schröder et al.   STROKE

SMA-Causing Missense Mutations in Survival motor neuron (Smn) Display a Wide Range of Phenotypes When Modeled in Drosophila

(2014) Kavita Praveen et al.   PLoS Genetics

Dynamic control of Cajal body number during zebrafish embryogenesis

(2014) Magdalena Strzelecka et al.   Nucleus

Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis

(2014) I. I. Enwerem et al.   Biology Open

At the “Junction” of Spinal Muscular Atrophy Pathogenesis: The Role of Neuromuscular Junction Dysfunction in SMA Disease Progression

(2013) B. Goulet et al.   CURRENT MOLECULAR MEDICINE

Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects

(2013) Marie Eve Brault et al.   HUMAN MOLECULAR GENETICS

Signals controlling Cajal body assembly and function

(2013) Michael D. Hebert   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Whole-genome screening identifies proteins localized to distinct nuclear bodies

(2013) Ka-wing Fong et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

(2013) Z. Wu et al.   JOURNAL OF CELL SCIENCE

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein

(2013) Deborah Y. Kwon et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

(2013) Stig E Bojesen et al.   NATURE GENETICS

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

(2013) Jun Tang et al.   PLoS One

Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes

(2013) E. L. Garcia et al.   RNA

Phosphorylation regulates coilin activity and RNA association

(2013) H. J. Broome et al.   Biology Open

An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function

(2012) Francesco Lotti et al.   CELL

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

(2012) Sarah Schulz et al.   EMBO REPORTS

Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy

(2012) Olga Tapia et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-Survival Motor Neuron

(2012) Ke-Jun Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies

(2012) Benoît Renvoisé et al.   JOURNAL OF CELL SCIENCE

The integrator complex is required for integrity of Cajal bodies

(2012) H. Takata et al.   JOURNAL OF CELL SCIENCE

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

(2012) J. Chung et al.   JOURNAL OF CELL SCIENCE

In Vitro RNase and Nucleic Acid Binding Activities Implicate Coilin in U snRNA Processing

(2012) Hanna J. Broome et al.   PLoS One

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects

(2012) Kavita Praveen et al.   Cell Reports

Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A

(2011) Chia-Yen Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

(2011) F. Zhong et al.   GENES & DEVELOPMENT

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

(2011) Marta Sanz-García et al.   Journal of Proteomics

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study

(2011) Götz Thomalla et al.   LANCET NEUROLOGY

Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

(2011) George Z. Mentis et al.   NEURON

Coilin Phosphomutants Disrupt Cajal Body Formation, Reduce Cell Proliferation and Produce a Distinct Coilin Degradation Product

(2011) Zunamys I. Carrero et al.   PLoS One

SMN in spinal muscular atrophy and snRNP biogenesis

(2011) Tristan H. Coady et al.   Wiley Interdisciplinary Reviews-RNA

Phosphorylation and the Cajal body: Modification in search of function

(2010) Michael D. Hebert   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nucleolar targeting of coilin is regulated by its hypomethylation state

(2010) Olga Tapia et al.   CHROMOSOMA

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts

(2010) Shih-Hsien Hsu et al.   CLINICA CHIMICA ACTA

Mutation in the Q28SDD31SD site, but not in the two SQ sites of the survival of motor neuron protein, affects its foci formation

(2010) Aoki   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cajal body surveillance of U snRNA export complex assembly

(2010) Tatsuya Suzuki et al.   JOURNAL OF CELL BIOLOGY

Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT

(2010) W Oh et al.   ONCOGENE

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

(2010) Salah Mahmoudi et al.   PLOS BIOLOGY

Coilin phosphorylation mediates interaction with SMN and SmB′

(2009) Cory G. Toyota et al.   CHROMOSOMA

Pathogenic NAP57 mutations decrease ribonucleoprotein assembly in dyskeratosis congenita

(2009) P. N. Grozdanov et al.   HUMAN MOLECULAR GENETICS

The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy

(2009) B. Renvoise et al.   HUMAN MOLECULAR GENETICS

Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines

(2009) S. M. Hearst et al.   JOURNAL OF CELL SCIENCE

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

Fibroblast growth factor-2 regulates the stability of nuclear bodies

(2009) A.-F. Bruns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

The SMN Protein is a Key Regulator of Nuclear Architecture in Differentiating Neuroblastoma Cells

(2009) Allyson K. Clelland et al.   TRAFFIC

Poly (ADP-Ribose) Polymerase 1 Is Required for Protein Localization to Cajal Body

(2009) Elena Kotova et al.   PLoS Genetics

Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5

(2008) Alexander-Francisco Bruns et al.   BIOLOGICAL CHEMISTRY

PML NBs (ND10) and Daxx: from nuclear structure to protein function

(2008) Cory et al.   Frontiers in Bioscience-Landmark

SUMO-1 transiently localizes to Cajal bodies in mammalian neurons

(2008) J. Navascues et al.   JOURNAL OF STRUCTURAL BIOLOGY

Regulation of SMN Protein Stability

(2008) B. G. Burnett et al.   MOLECULAR AND CELLULAR BIOLOGY

Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP

(2008) C. Trahan et al.   RNA