- Home
- Publications
- Publication Search
- Publication Details
Title
Phase separation-deficient TDP43 remains functional in splicing
Authors
Keywords
-
Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-10-26
DOI
10.1038/s41467-019-12740-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
- (2019) Jacob R. Mann et al. NEURON
- Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
- (2019) Fatima Gasset-Rosa et al. NEURON
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
- (2019) Peter T Nelson et al. BRAIN
- Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions
- (2018) Erik W. Martin et al. BIOCHEMISTRY
- Functional Implications of Intracellular Phase Transitions
- (2018) Alex S. Holehouse et al. BIOCHEMISTRY
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
- (2018) Seema Qamar et al. CELL
- TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues
- (2018) Hao-Ru Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
- (2018) Elizabeth L. Guenther et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
- (2018) Feng Luo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNA buffers the phase separation behavior of prion-like RNA binding proteins
- (2018) Shovamayee Maharana et al. SCIENCE
- Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
- (2018) Michael P. Hughes et al. SCIENCE
- Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
- (2018) Elizabeth L. Guenther et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
- (2018) Feng Luo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
- (2018) Elke Bogaert et al. Cell Reports
- Pi-Pi contacts are an overlooked protein feature relevant to phase separation
- (2018) Robert McCoy Vernon et al. eLife
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
- (2018) Leeanne McGurk et al. MOLECULAR CELL
- Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
- (2018) L. McGurk et al. Acta Neuropathologica Communications
- The wisdom of crowds: regulating cell function through condensed states of living matter
- (2017) Simon Alberti JOURNAL OF CELL SCIENCE
- Phase separation drives heterochromatin domain formation
- (2017) Amy R. Strom et al. NATURE
- Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
- (2017) Lindsay A. Becker et al. NATURE
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- (2017) Adam G. Larson et al. NATURE
- Biomolecular condensates: organizers of cellular biochemistry
- (2017) Salman F. Banani et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
- (2017) Pallavi P. Gopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
- (2017) Jacob P. Brady et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
- (2017) Tariq Afroz et al. Nature Communications
- The TDP-43 N-terminal domain structure at high resolution
- (2016) Miguel Mompeán et al. FEBS Journal
- Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
- (2016) Chi W. Pak et al. MOLECULAR CELL
- ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
- (2016) Alexander E. Conicella et al. STRUCTURE
- In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes
- (2016) Hermann Broder Schmidt et al. Cell Reports
- ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
- (2016) Liangzhong Lim et al. PLOS BIOLOGY
- The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei
- (2015) Siheng Xiang et al. CELL
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Nuclear bodies: the emerging biophysics of nucleoplasmic phases
- (2015) Lian Zhu et al. CURRENT OPINION IN CELL BIOLOGY
- Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
- (2015) Yuan Lin et al. MOLECULAR CELL
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
- (2015) Tetsuro Murakami et al. NEURON
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Protein disorder, prion propensities, and self-organizing macromolecular collectives
- (2013) Liliana Malinovska et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion
- (2013) Lei-Lei Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
- (2013) E. S. Arnold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes
- (2012) Aksana A Labokha et al. EMBO JOURNAL
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Coacervation of tropoelastin
- (2010) Giselle C. Yeo et al. ADVANCES IN COLLOID AND INTERFACE SCIENCE
- SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations
- (2010) S. Millecamps et al. JOURNAL OF MEDICAL GENETICS
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo
- (2009) A. D'Ambrogio et al. NUCLEIC ACIDS RESEARCH
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started