A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

Reverse GWAS: Using genetics to identify and model phenotypic subtypes

(2019) Andy Dahl et al.   PLoS Genetics

PCSK9

(2018) Michael D. Shapiro et al.   CIRCULATION RESEARCH

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

(2018) Tanya M Teslovich et al.   HUMAN MOLECULAR GENETICS

Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke

(2018) Michael V. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of LIPC -250G/A and -514C/T polymorphisms and hypertension: a systematic review and meta-analysis

(2018) Xingsheng Zhao et al.   Lipids in Health and Disease

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

(2018) Johanna M. Colijn et al.   OPHTHALMOLOGY

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

(2017) Markku Laakso et al.   JOURNAL OF LIPID RESEARCH

Covariate selection for association screening in multiphenotype genetic studies

(2017) Hugues Aschard et al.   NATURE GENETICS

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

(2017) James P. Davis et al.   PLoS Genetics

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

(2016) Peter Würtz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies

(2015) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

Genetics of human metabolism: an update

(2015) Gabi Kastenmüller et al.   HUMAN MOLECULAR GENETICS

Association of USF1 and APOA5 polymorphisms with familial combined hyperlipidemia in an Italian population

(2015) Maria Donata Di Taranto et al.   MOLECULAR AND CELLULAR PROBES

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

(2015) Harmen H. M. Draisma et al.   Nature Communications

CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration

(2015) Ya-Feng Wang et al.   Scientific Reports

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium

(2014) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolomic Biomarkers for Obesity in Humans: A Short Review

(2014) Sebastian Rauschert et al.   ANNALS OF NUTRITION AND METABOLISM

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Mendelian randomization of blood lipids for coronary heart disease

(2014) Michael V. Holmes et al.   EUROPEAN HEART JOURNAL

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort

(2013) Eugene P. Rhee et al.   Cell Metabolism

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

(2012) Michael Inouye et al.   PLoS Genetics

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

(2011) Yi Yu et al.   HUMAN MOLECULAR GENETICS

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

(2011) T. Tukiainen et al.   HUMAN MOLECULAR GENETICS

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Metabonomic, transcriptomic, and genomic variation of a population cohort

(2010) Michael Inouye et al.   Molecular Systems Biology

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

(2010) Mathew J. Barber et al.   PLoS One

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

(2010) B. M. Neale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism

(2009) Pasi Soininen et al.   ANALYST

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case–cohort study, 1984–2002

(2008) C Holzapfel et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Evidence of different metabolic phenotypes in humans

(2008) M. Assfalg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics