Genetics of human metabolism: an update

Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample

(2015) Esther Ng et al.   ENVIRONMENTAL RESEARCH

Nonadditive Effects of Genes in Human Metabolomics

(2015) Yakov A. Tsepilov et al.   GENETICS

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

(2015) Harmen H. M. Draisma et al.   Nature Communications

The Human Blood Metabolome-Transcriptome Interface

(2015) Jörg Bartel et al.   PLoS Genetics

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

(2015) Ayşe Demirkan et al.   PLoS Genetics

Nonadditive Effects of Genes in Human Metabolomics

(2015) Yakov A. Tsepilov et al.   GENETICS

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

Using Gene Expression to Improve the Power of Genome-Wide Association Analysis

(2014) Yen-Yi Ho et al.   HUMAN HEREDITY

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses

(2014) Janina S. Ried et al.   HUMAN MOLECULAR GENETICS

Genetic regulation of mouse liver metabolite levels

(2014) A. Ghazalpour et al.   Molecular Systems Biology

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism

(2014) Wei Chen et al.   NATURE GENETICS

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

A decade of innovation in pharmaceutical R&D: the Chorus model

(2014) Paul K. Owens et al.   NATURE REVIEWS DRUG DISCOVERY

Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

(2014) Anja Kittel et al.   PLoS One

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

(2014) A. R. Stiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AGXT2: a promiscuous aminotransferase

(2014) Roman N. Rodionov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links

(2014) Rico Rueedi et al.   PLoS Genetics

Genetic Determinants Influencing Human Serum Metabolome among African Americans

(2014) Bing Yu et al.   PLoS Genetics

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma

(2013) J. S. Ried et al.   ALLERGY

A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort

(2013) Eugene P. Rhee et al.   Cell Metabolism

Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway

(2013) Jason H.Y. Wu et al.   Circulation-Cardiovascular Genetics

Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine

(2013) Marcus E. Kleber et al.   Circulation-Cardiovascular Genetics

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

(2013) W. Xie et al.   DIABETES

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality

(2013) Ilkka Seppälä et al.   EUROPEAN HEART JOURNAL

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

(2013) Ann-Kristin Petersen et al.   HUMAN MOLECULAR GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma

(2013) Johannes Raffler et al.   Genome Medicine

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

(2012) Ann-Kristin Petersen et al.   BMC BIOINFORMATICS

Current status on genome–metabolome-wide associations: an opportunity in nutrition research

(2012) Ivan Montoliu et al.   Genes and Nutrition

A Genome-Wide Assessment of Variability in Human Serum Metabolism

(2012) Mun-Gwan Hong et al.   HUMAN MUTATION

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

(2012) Jacqueline N. Milton et al.   PLoS One

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

(2012) Michael Inouye et al.   PLoS Genetics

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information

(2012) Jan Krumsiek et al.   PLoS Genetics

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

(2011) Jan Krumsiek et al.   BMC Systems Biology

UGT1A1 is a major locus influencing bilirubin levels in African Americans

(2011) Guanjie Chen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

(2011) T. Tukiainen et al.   HUMAN MOLECULAR GENETICS

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Genome-wide association of serum bilirubin levels in Korean population

(2010) Tae-Wook Kang et al.   HUMAN MOLECULAR GENETICS

Genetic loci influencing kidney function and chronic kidney disease

(2010) John C Chambers et al.   NATURE GENETICS

Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

(2010) Gordan Lauc et al.   PLoS Genetics

Genome-wide association meta-analysis for total serum bilirubin levels

(2009) A. D. Johnson et al.   HUMAN MOLECULAR GENETICS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

Systems biology: Metabonomics

(2008) Jeremy K. Nicholson et al.   NATURE

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

(2008) David Melzer et al.   PLoS Genetics