Shank3 Exons 14–16 Deletion in Glutamatergic Neurons Leads to Social and Repetitive Behavioral Deficits Associated With Increased Cortical Layer 2/3 Neuronal Excitability

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function

(2019) Li Wang et al.   MOLECULAR PSYCHIATRY

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

RNA-Sequencing and Bioinformatics Analysis of Long Noncoding RNAs and mRNAs in the Prefrontal Cortex of Mice Following Repeated Social Defeat Stress

(2019) Xian Wang et al.   Biomed Research International

A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability

(2019) Li Wang et al.   MOLECULAR PSYCHIATRY

Shank3 modulates sleep and expression of circadian transcription factors

(2019) Ashley M Ingiosi et al.   eLife

Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

(2019) Ye-Eun Yoo et al.   Frontiers in Molecular Neuroscience

Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex

(2018) Mari A. Virtanen et al.   Brain Structure & Function

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

SHANK genes in autism: Defining therapeutic targets

(2018) Adele Mossa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice

(2018) Chantelle Fourie et al.   Frontiers in Cellular Neuroscience

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

(2018) Taesun Yoo et al.   Frontiers in Cellular Neuroscience

SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction

(2018) Sebastiano Bariselli et al.   Frontiers in Molecular Neuroscience

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

(2017) Wenting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

(2017) S C Page et al.   MOLECULAR PSYCHIATRY

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

(2017) Aslihan Selimbeyoglu et al.   Science Translational Medicine

VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line

(2017) Sebastiano Bariselli et al.   SYNAPSE

Neuroanatomical Substrates of Rodent Social Behavior: The Medial Prefrontal Cortex and Its Projection Patterns

(2017) Jaewon Ko   Frontiers in Neural Circuits

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

(2017) Sameer C. Dhamne et al.   Molecular Autism

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

(2017) Yeunkum Lee et al.   Frontiers in Molecular Neuroscience

Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder

(2017) Dominik Reim et al.   Frontiers in Molecular Neuroscience

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function

(2016) Thomas C. Jaramillo et al.   Autism Research

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

(2016) Kun Li et al.   CELL

The spectrum of epilepsy and electroencephalographic abnormalities due toSHANK3loss-of-function mutations

(2016) J. Lloyd Holder et al.   EPILEPSIA

Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals

(2016) Sonja Halbedl et al.   JOURNAL OF NEUROCHEMISTRY

Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors

(2016) S. Ha et al.   JOURNAL OF NEUROSCIENCE

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

(2016) C Vicidomini et al.   MOLECULAR PSYCHIATRY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Neurobiology of social behavior abnormalities in autism and Williams syndrome

(2016) Boaz Barak et al.   NATURE NEUROSCIENCE

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

(2016) Rui T Peixoto et al.   NATURE NEUROSCIENCE

SHANK3 controls maturation of social reward circuits in the VTA

(2016) Sebastiano Bariselli et al.   NATURE NEUROSCIENCE

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

Morphological Alterations in the Thalamus, Striatum and Pallidum in Autism Spectrum Disorder

(2016) Manuela Schuetze et al.   NEUROPSYCHOPHARMACOLOGY

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

(2016) F. Yi et al.   SCIENCE

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

(2016) Xiaoming Wang et al.   Nature Communications

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

(2016) Federica Filice et al.   Molecular Brain

Striatal Circuits as a Common Node for Autism Pathophysiology

(2016) Marc V. Fuccillo   Frontiers in Neuroscience

Altered Striatal Synaptic Function and Abnormal Behaviour inShank3Exon4-9 Deletion Mouse Model of Autism

(2015) Thomas C. Jaramillo et al.   Autism Research

Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist

(2015) Ekrem Dere et al.   BEHAVIOURAL BRAIN RESEARCH

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

(2015) Carlo Sala et al.   JOURNAL OF NEUROCHEMISTRY

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

(2015) H. E. Speed et al.   JOURNAL OF NEUROSCIENCE

Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments

(2015) J Liang et al.   MOLECULAR PSYCHIATRY

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

(2015) Jiseok Lee et al.   Frontiers in Cellular Neuroscience

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors

(2015) Prerana Shrestha et al.   eLife

Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID

(2015) Daniela M Cochoy et al.   Molecular Autism

Striatal Development in Autism: Repetitive Behaviors and the Reward Circuitry

(2014) Gregor Kohls et al.   BIOLOGICAL PSYCHIATRY

Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

(2014) Patrick E. Rothwell et al.   CELL

Enhanced synapse remodelling as a common phenotype in mouse models of autism

(2014) Masaaki Isshiki et al.   Nature Communications

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

(2013) Marieke Langen et al.   BIOLOGICAL PSYCHIATRY

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Therapeutic approaches for shankopathies

(2013) Xiaoming Wang et al.   Developmental Neurobiology

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

Identification of two novelShank3transcripts in the developing mouse neocortex

(2013) Chikako Waga et al.   JOURNAL OF NEUROCHEMISTRY

Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

(2013) M. Kouser et al.   JOURNAL OF NEUROSCIENCE

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Pyramidal Neurons in Prefrontal Cortex Receive Subtype-Specific Forms of Excitation and Inhibition

(2013) Anthony T. Lee et al.   NEURON

A Neural Circuit for Memory Specificity and Generalization

(2013) W. Xu et al.   SCIENCE

Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

(2013) Latha Soorya et al.   Molecular Autism

Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders

(2012) Luigi Boccuto et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

(2012) Michael J. Schmeisser et al.   NATURE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability

(2011) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aberrant Striatal Functional Connectivity in Children with Autism

(2011) Adriana Di Martino et al.   BIOLOGICAL PSYCHIATRY

Hyperconnectivity and Slow Synapses during Early Development of Medial Prefrontal Cortex in a Mouse Model for Mental Retardation and Autism

(2011) Guilherme Testa-Silva et al.   CEREBRAL CORTEX

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Neuron Number and Size in Prefrontal Cortex of Children With Autism

(2011) Eric Courchesne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

(2011) F. Wang et al.   SCIENCE

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Molecular Mechanisms Generating and Stabilizing Terminal 22q13 Deletions in 44 Subjects with Phelan/McDermid Syndrome

(2011) Maria Clara Bonaglia et al.   PLoS Genetics

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism

(2010) Tania Rinaldi   Frontiers in Neural Circuits

The Medial Prefrontal Cortex and Integration in Autism

(2009) Dorit Ben Shalom   NEUROSCIENTIST

Social approach in genetically engineered mouse lines relevant to autism

(2008) S. S. Moy et al.   GENES BRAIN AND BEHAVIOR

Atypical recruitment of medial prefrontal cortex in autism spectrum disorders: An fMRI study of two executive function tasks

(2008) Sam J. Gilbert et al.   NEUROPSYCHOLOGIA

Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders

(2008) Maria Luisa Scattoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS