Flavivirus RNA-Dependent RNA Polymerase Interacts with Genome UTRs and Viral Proteins to Facilitate Flavivirus RNA Replication

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

(2019) Sundy Yang et al.   Cells

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

(2019) Ivan H. W. Ng et al.   ACS Infectious Diseases

Zika virus non‐structural protein 5 residue R681 is critical for dimer formation and enzymatic activity

(2019) Wuan‐Geok Saw et al.   FEBS LETTERS

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

(2019) Ludek Eyer et al.   JOURNAL OF VIROLOGY

Supramolecular arrangement of the full-length Zika virus NS5

(2019) Diego S. Ferrero et al.   PLoS Pathogens

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase

(2019) Shan Xu et al.   NUCLEIC ACIDS RESEARCH

Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses

(2019) Anna Dubankova et al.   ANTIVIRAL RESEARCH

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

(2018) Adam J. Lopez-Denman et al.   CELLULAR MICROBIOLOGY

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

(2018) Rolando Cannalire et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The rearrangement of motif F in the flavivirus RNA-directed RNA polymerase

(2018) Ulyana Potapova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development

(2018) Shun Chen et al.   PHARMACOLOGY & THERAPEUTICS

Molecular cloning and characterization of the genes encoding the proteins of Zika virus

(2017) Wangheng Hou et al.   GENE

Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication

(2017) Tadahisa Teramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A

(2017) Paul J. Bujalowski et al.   JOURNAL OF VIROLOGY

A CRISPR toolbox to study virus–host interactions

(2017) Andreas S. Puschnik et al.   NATURE REVIEWS MICROBIOLOGY

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

(2017) Crystall M. D. Swarbrick et al.   NUCLEIC ACIDS RESEARCH

The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase

(2017) Bo Shu et al.   RNA Biology

The 5′ and 3′ Untranslated Regions of the Flaviviral Genome

(2017) Wy Ng et al.   Viruses-Basel

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

(2017) Andre S. Godoy et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes

(2017) Alba Fernández-Sanlés et al.   Frontiers in Microbiology

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

(2016) Christian G. Noble et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication

(2016) Kenneth Hodge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Structure of the NS3 helicase from Zika virus

(2016) Rinku Jain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA Structure Duplications and Flavivirus Host Adaptation

(2016) Sergio M. Villordo et al.   TRENDS IN MICROBIOLOGY

Structure of the NS3 helicase from Zika virus

(2016) Rinku Jain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

(2016) Moon Y. F. Tay et al.   PLoS Pathogens

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

(2016) Federico A. De Maio et al.   PLoS Pathogens

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

(2016) Siew Pheng Lim et al.   PLoS Pathogens

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

(2016) Valerie J. Klema et al.   PLoS Pathogens

Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

(2016) Zhong-Yu Liu et al.   eLife

The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development

(2015) Dahai Luo et al.   ANTIVIRAL RESEARCH

Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy

(2015) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus

(2015) Jing Zou et al.   JOURNAL OF VIROLOGY

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

The C-terminal 50 Amino Acid Residues of Dengue NS3 Protein Are Important for NS3-NS5 Interaction and Viral Replication

(2014) Moon Y. F. Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection

(2014) Johanna E. Fraser et al.   JOURNAL OF INFECTIOUS DISEASES

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System

(2014) D. L. Akey et al.   SCIENCE

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

(2013) M.Y.F. Tay et al.   ANTIVIRAL RESEARCH

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

(2013) Holger Hannemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

(2013) A. Kumar et al.   JOURNAL OF VIROLOGY

Membrane Topology and Function of Dengue Virus NS2A Protein

(2013) X. Xie et al.   JOURNAL OF VIROLOGY

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

(2013) C. G. Noble et al.   JOURNAL OF VIROLOGY

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

(2013) Parag Surana et al.   NUCLEIC ACIDS RESEARCH

Protein–protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells

(2013) Li Yu et al.   VIROLOGY

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations

(2012) Abdelrahman S. Mayhoub   BIOORGANIC & MEDICINAL CHEMISTRY

Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus

(2012) S. Youn et al.   JOURNAL OF VIROLOGY

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

(2012) R. T. Mosley et al.   JOURNAL OF VIROLOGY

Motif D of Viral RNA-Dependent RNA Polymerases Determines Efficiency and Fidelity of Nucleotide Addition

(2012) Xiaorong Yang et al.   STRUCTURE

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase

(2010) Claudia V. Filomatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay of RNA Elements in the Dengue Virus 5' and 3' Ends Required for Viral RNA Replication

(2010) P. Friebe et al.   JOURNAL OF VIROLOGY

RNA-dependent RNA polymerases from Flaviviridae

(2009) Kyung H Choi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

(2009) Stephen M. Rawlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

(2008) M. F. Lodeiro et al.   JOURNAL OF VIROLOGY

Conformational Changes in the Solution Structure of the Dengue Virus 5' End in the Presence and Absence of the 3' Untranslated Region

(2008) C. Polacek et al.   JOURNAL OF VIROLOGY

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

(2008) Hongping Dong et al.   VIROLOGY