Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

(2019) Olga L. Rojas et al.   CELL

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

(2019) Juliana Komuczki et al.   IMMUNITY

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View

(2018) Elizabeth A. Mills et al.   Frontiers in Immunology

Targeting the GM-CSF receptor for the treatment of CNS autoimmunity

(2017) Igal Ifergan et al.   JOURNAL OF AUTOIMMUNITY

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis

(2017) Marc-André Lécuyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

(2016) Lukas Haider et al.   BRAIN

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

(2016) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS Autoimmunity

(2016) Natalia B. Pikor et al.   Frontiers in Immunology

Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis

(2016) Rui Li et al.   Frontiers in Immunology

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy

(2015) Javad Rasouli et al.   JOURNAL OF IMMUNOLOGY

Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing–remitting multiple sclerosis

(2015) Margaret E. Walker-Caulfield et al.   JOURNAL OF NEUROIMMUNOLOGY

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

(2015) Rui Li et al.   Science Translational Medicine

Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis

(2014) Laure Michel et al.   CLINICAL IMMUNOLOGY

Syntenin-1 and Ezrin Proteins Link Activated Leukocyte Cell Adhesion Molecule to the Actin Cytoskeleton

(2014) Cicerone Tudor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALCAM and CD6 — multiple sclerosis risk factors

(2014) M. Wagner et al.   JOURNAL OF NEUROIMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

B Cells Promote Induction of Experimental Autoimmune Encephalomyelitis by Facilitating Reactivation of T Cells in the Central Nervous System

(2013) E. R. Pierson et al.   JOURNAL OF IMMUNOLOGY

ALCAM — Novel multiple sclerosis locus interfering with HLA-DRB1*1501

(2013) Marta Wagner et al.   JOURNAL OF NEUROIMMUNOLOGY

Secondary B Cell Receptor Diversification Is Necessary for T Cell Mediated Neuro-Inflammation during Experimental Autoimmune Encephalomyelitis

(2013) Georgina Galicia et al.   PLoS One

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

(2012) Sung R. Choi et al.   BRAIN

ALCAM/CD166 adhesive function is regulated by the tetraspanin CD9

(2012) Alvaro Gilsanz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions

(2011) Igal Ifergan et al.   ANNALS OF NEUROLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

(2011) D. M. Kofler et al.   JOURNAL OF IMMUNOLOGY

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

(2011) Stephanie Knippenberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis

(2010) Laura Piccio et al.   ARCHIVES OF NEUROLOGY

Detection of Epstein–Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look

(2010) Francesca Aloisi et al.   BRAIN

Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein

(2010) Christopher T. Harp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis

(2008) Christopher T. Harp et al.   CLINICAL IMMUNOLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN