Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin αIIbβ3Activation and Granule Secretion in Platelets

An important role for Akt3 in platelet activation and thrombosis

(2011) K. A. O'Brien et al.   BLOOD

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

A PLCβ/PI3Kγ-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis

(2011) Wenwen Tang et al.   DEVELOPMENTAL CELL

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

(2011) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

Protein kinase C alpha enhances sodium–calcium exchange during store-operated calcium entry in mouse platelets

(2010) Matthew T. Harper et al.   CELL CALCIUM

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

(2010) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

(2010) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets

(2009) Roger W. Hunter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase Cα: disease regulator and therapeutic target

(2009) Olga Konopatskaya et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GSK3  is a negative regulator of platelet function and thrombosis

(2008) D. Li et al.   BLOOD

The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB

(2008) R. W. HUNTER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

NO-synthase-NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity

(2008) S. GAMBARYAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS