Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Asparagine Deamidation Dependence on Buffer Type, pH, and Temperature

(2013) Amanda L. Pace et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule

(2013) David Ouellette et al.   mAbs

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies

(2012) Sheng Yin et al.   PHARMACEUTICAL RESEARCH

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Rates and impact of human antibody glycation in vivo

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

N-terminal Glutamate to Pyroglutamate Conversionin Vivofor Human IgG2 Antibodies

(2011) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of trisulfide modification in antibodies

(2010) Sheng Gu et al.   ANALYTICAL BIOCHEMISTRY

C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo

(2010) Bing Cai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Assessing monoclonal antibody product quality attribute criticality through clinical studies

(2010) Andrew M. Goetze et al.   mAbs

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

(2009) Boxu Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution

(2008) Stephan Schilling et al.   BIOLOGICAL CHEMISTRY

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

(2008) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human IgG2 Antibody Disulfide Rearrangementin Vivo

(2008) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES