Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule

Which are the antibodies to watch in 2012?

(2012) Janice M. Reichert   mAbs

World Bispecific Antibody Summit, September 27–28, 2011, Boston, MA

(2012) Eugen Dhimolea et al.   mAbs

Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies

(2012) Sheng Yin et al.   PHARMACEUTICAL RESEARCH

Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map Analysis

(2011) X. Christopher Yu et al.   ANALYTICAL CHEMISTRY

HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region

(2011) Daniel Boyd et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Taylor Dispersion Analysis Compared to Dynamic Light Scattering for the Size Analysis of Therapeutic Peptides and Proteins and Their Aggregates

(2011) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH

Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody

(2011) Alavattam Sreedhara et al.   PHARMACEUTICAL RESEARCH

Identification of isomerization and racemization of aspartate in the Asp–Asp motifs of a therapeutic protein

(2010) Jennifer Zhang et al.   ANALYTICAL BIOCHEMISTRY

Antibodies to watch in 2010

(2010) Janice M. Reichert   mAbs

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Direct Identification and Quantification of Aspartyl Succinimide in an IgG2 mAb by RapiGest Assisted Digestion

(2009) Holly Z. Huang et al.   ANALYTICAL CHEMISTRY

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

(2009) Boxu Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Formulation Development of Antibodies Using Robotic System and High-Throughput Laboratory (HTL)

(2009) Hui Zhao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation

(2008) Andrea Hawe et al.   ANALYTICAL BIOCHEMISTRY

Separation and Characterization of an IgG2 Antibody Containing a Cyclic Imide in CDR1 of Light Chain by Hydrophobic Interaction Chromatography and Mass Spectrometry

(2008) John Valliere-Douglass et al.   ANALYTICAL CHEMISTRY

Hydrophobic Interaction Chromatography of Soluble Interleukin I Receptor Type II To Reveal Chemical Degradations Resulting in Loss of Potency

(2008) Yuling Zhang et al.   ANALYTICAL CHEMISTRY

Separation of populations of antibody variants by fine tuning of hydrophobic-interaction chromatography operating conditions

(2008) John Valliere-Douglass et al.   JOURNAL OF CHROMATOGRAPHY A