Assessing monoclonal antibody product quality attribute criticality through clinical studies

A Therapeutic Anti-VEGF Antibody with Increased Potency Independent of Pharmacokinetic Half-life

(2010) Y. A. Yeung et al.   CANCER RESEARCH

Naturally occurring glycan forms of human immunoglobulins G1 and G2

(2010) Gregory C. Flynn et al.   MOLECULAR IMMUNOLOGY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Direct Identification and Quantification of Aspartyl Succinimide in an IgG2 mAb by RapiGest Assisted Digestion

(2009) Holly Z. Huang et al.   ANALYTICAL CHEMISTRY

Large-Scale Identification and Quantification of Covalent Modifications in Therapeutic Proteins

(2009) Zhongqi Zhang   ANALYTICAL CHEMISTRY

Human antibody Fc deamidation in vivo

(2009) Y. Diana Liu et al.   BIOLOGICALS

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Roadmap for implementation of quality by design (QbD) for biotechnology products

(2009) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY

The effect of Fc glycan forms on human IgG2 antibody clearance in humans

(2008) X. Chen et al.   GLYCOBIOLOGY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IgG2 Antibody Disulfide Rearrangementin Vivo

(2008) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice

(2007) Thomas A. Millward et al.   BIOLOGICALS

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES