Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies

Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map Analysis

(2011) X. Christopher Yu et al.   ANALYTICAL CHEMISTRY

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Rates and impact of human antibody glycation in vivo

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

N-terminal Glutamate to Pyroglutamate Conversionin Vivofor Human IgG2 Antibodies

(2011) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo

(2010) Bing Cai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations

(2010) Jennifer C. Rea et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: Effects of the solvent dielectric

(2010) Todd V. Brennan et al.   PROTEIN SCIENCE

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Investigation of Sample Preparation Artifacts Formed during the Enzymatic Release of N-Linked Glycans prior to Analysis by Capillary Electrophoresis

(2009) Yong Liu et al.   ANALYTICAL CHEMISTRY

Human antibody Fc deamidation in vivo

(2009) Y. Diana Liu et al.   BIOLOGICALS

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

(2009) Sandipan Sinha et al.   PROTEIN SCIENCE

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

(2008) Dingjiang Liu et al.   BIOCHEMISTRY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The art of antibody process development

(2008) David E. Steinmeyer et al.   DRUG DISCOVERY TODAY

Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals

(2008) Nigel Jenkins et al.   MOLECULAR BIOTECHNOLOGY

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

(2008) Georgeen Gaza-Bulseco et al.   PHARMACEUTICAL RESEARCH

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES