Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells

Beta-cell mitochondrial carriers and the diabetogenic stress response

(2016) Thierry Brun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diluted serum from calorie-restricted animals promotes mitochondrial β-cell adaptations and protect against glucolipotoxicity

(2016) Fernanda M. Cerqueira et al.   FEBS Journal

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells

(2015) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells

(2014) Tetsuro Matsunaga et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Genome-wide Analysis of DNA Methylation Variations Caused by Chronic Glucolipotoxicity in Beta-Cells

(2014) Y. Hu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

(2014) Michala Prause et al.   PLoS One

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

(2013) Jonathan Barlow et al.   BIOCHEMICAL JOURNAL

Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

(2013) Baggavalli P Somesh et al.   BMC CELL BIOLOGY

Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: Potential mechanisms and functional consequences

(2012) Anjaneyulu Kowluru et al.   BIOCHEMICAL PHARMACOLOGY

GLP1-derived nonapeptide GLP1(28–36)amide protects pancreatic β-cells from glucolipotoxicity

(2012) Zhengu Liu et al.   JOURNAL OF ENDOCRINOLOGY

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondria-targeted Antioxidants Protect Pancreatic β-cells against Oxidative Stress and Improve Insulin Secretion in Glucotoxicity and Glucolipotoxicity

(2011) Sangbin Lim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells

(2011) Bhavaani Jayaram et al.   Islets

Impact of Sur1 gene inactivation on the morphology of mouse pancreatic endocrine tissue

(2009) Ihsane Marhfour et al.   CELL AND TISSUE RESEARCH

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes indb/dbMice

(2009) Jamie S. Harmon et al.   ENDOCRINOLOGY

Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress

(2009) Belinda Gier et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive Up-Regulation of Their Antioxidant Defenses

(2009) Grégory Lacraz et al.   PLoS One

Insulin exocytosis in Goto-Kakizaki rat β-cells subjected to long-term glinide or sulfonylurea treatment

(2008) Junko Kawai et al.   BIOCHEMICAL JOURNAL

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS