Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
Authors
Keywords
-
Journal
NATURE
Volume 575, Issue 7784, Pages 704-710
Publisher
Springer Science and Business Media LLC
Online
2019-11-21
DOI
10.1038/s41586-019-1768-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Conformational control and DNA-binding mechanism of the metazoan origin recognition complex
- (2018) Franziska Bleichert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
- (2018) Tristan Ian Croll Acta Crystallographica Section D-Structural Biology
- Structure of the origin recognition complex bound to DNA replication origin
- (2018) Ningning Li et al. NATURE
- Replication origin–flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence
- (2017) Megan D. Warner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
- (2017) Yuanliang Zhai et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
- (2017) Simina Ticau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1
- (2017) Zuanning Yuan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model
- (2017) Yasunori Noguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading
- (2017) Gideon Coster et al. SCIENCE
- Cryo-EM structure of a licensed DNA replication origin
- (2017) Ferdos Abid Ali et al. Nature Communications
- Cdt1 stabilizes an open MCM ring for helicase loading
- (2017) Jordi Frigola et al. Nature Communications
- Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
- (2017) Yuanliang Zhai et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
- (2017) Simina Ticau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1
- (2017) Zuanning Yuan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading
- (2015) Simina Ticau et al. CELL
- Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA
- (2015) Julien Gros et al. MOLECULAR CELL
- Structure of the eukaryotic MCM complex at 3.8 Å
- (2015) Ningning Li et al. NATURE
- Crystal structure of the eukaryotic origin recognition complex
- (2015) Franziska Bleichert et al. NATURE
- Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation
- (2014) Sukhyun Kang et al. MOLECULAR CELL
- Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase
- (2014) Gideon Coster et al. MOLECULAR CELL
- An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly
- (2013) Alejandra Fernández-Cid et al. MOLECULAR CELL
- ATPase-dependent quality control of DNA replication origin licensing
- (2013) Jordi Frigola et al. NATURE
- CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6
- (2011) S. Chen et al. GENES & DEVELOPMENT
- Conserved nucleosome positioning defines replication origins
- (2010) M. L. Eaton et al. GENES & DEVELOPMENT
- Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing
- (2009) Dirk Remus et al. CELL
- A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
- (2009) C. Evrin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More