Replication origin–flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

(2017) Roxana Georgescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

(2017) Gideon Coster et al.   SCIENCE

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleosomes influence multiple steps during replication initiation

(2017) Ishara F Azmi et al.   eLife

Structure of the active form of human origin recognition complex and its ATPase motor module

(2017) Ante Tocilj et al.   eLife

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

Crystal structure of the eukaryotic origin recognition complex

(2015) Franziska Bleichert et al.   NATURE

Repair of a DNA-Protein Crosslink by Replication-Coupled Proteolysis

(2014) Julien P. Duxin et al.   CELL

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

(2013) Franziska Bleichert et al.   eLife

High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast

(2012) I. Liachko et al.   GENOME RESEARCH

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6

(2011) S. Chen et al.   GENES & DEVELOPMENT

High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements

(2011) FuJung Chang et al.   NUCLEIC ACIDS RESEARCH

Conserved nucleosome positioning defines replication origins

(2010) M. L. Eaton et al.   GENES & DEVELOPMENT

Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-Wide Analysis of Chromatin Structure

(2010) Nicolas M. Berbenetz et al.   PLoS Genetics

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Chromosome III Replicators Reveals an Unusual Structure for the ARS318 Silencer Origin and a Conserved WTW Sequence within the Origin Recognition Complex Binding Site

(2008) F. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

An ARS Element Inhibits DNA Replication through a SIR2-Dependent Mechanism

(2008) Amber Crampton et al.   MOLECULAR CELL