Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

(2014) Anne C. Conibear et al.   CHEMBIOCHEM

Disulfide-rich macrocyclic peptides as templates in drug design

(2014) Susan E. Northfield et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides

(2014) Olivier Cheneval et al.   JOURNAL OF ORGANIC CHEMISTRY

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

(2014) Conan K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Form and Function in Cyclic Peptide Natural Products: A Pharmacokinetic Perspective

(2013) Andrew T. Bockus et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Cyclic Cystine Ladder in θ-Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

(2013) Anne C. Conibear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

(2013) Yanbin Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conference Scene: Advances in RNA nanotechnology promise to transform medicine

(2013) Neocles Leontis et al.   Nanomedicine

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Characterization of the Cyclic Cystine Ladder Motif of θ-Defensins

(2012) Anne C. Conibear et al.   BIOCHEMISTRY

Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1)

(2012) Teshome L. Aboye et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.

(2012) Robert I. Lehrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Minireview Series on Circular Proteins

(2012) David J. Craik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Synthesis of Circular Polypeptides

(2012) Teshome L. Aboye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

(2012) Teshome L. Aboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protease-Resistant Peptide Ligands from a Knottin Scaffold Library

(2011) Jennifer A. Getz et al.   ACS Chemical Biology

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals

(2011) Anne C. Conibear et al.   ISRAEL JOURNAL OF CHEMISTRY

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Modifications Designed to Improve Peptide Stability: Incorporation of Non-Natural Amino Acids, Pseudo-Peptide Bonds, and Cyclization

(2010) Luca Gentilucci et al.   CURRENT PHARMACEUTICAL DESIGN

Intracellular targets of RGDS peptide in melanoma cells

(2010) Maria Aguzzi et al.   Molecular Cancer

The Medicinal Chemistry of Peptides

(2009) J. Nestor Jr.   CURRENT MEDICINAL CHEMISTRY

Cyclotides as templates in drug design

(2009) Sónia Troeira Henriques et al.   DRUG DISCOVERY TODAY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma

(2008) V. Fogal et al.   CANCER RESEARCH

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics

(2008) A. C. Mita et al.   CLINICAL CANCER RESEARCH

The design, structures and therapeutic potential of protein epitope mimetics

(2008) John A. Robinson et al.   DRUG DISCOVERY TODAY

Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

(2008) Harald Kolmar   FEBS Journal

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

(2008) Sunithi Gunasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY