The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

The Cyclic Cystine Ladder in θ-Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

(2013) Anne C. Conibear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids

(2013) Alexander Bochen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

(2012) Jonathan E. Bock et al.   ACS Chemical Biology

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro

(2012) Florian Rechenmacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Characterization of the Cyclic Cystine Ladder Motif of θ-Defensins

(2012) Anne C. Conibear et al.   BIOCHEMISTRY

Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1)

(2012) Teshome L. Aboye et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.

(2012) Robert I. Lehrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Minireview Series on Circular Proteins

(2012) David J. Craik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1

(2012) Rasmus Eliasen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

(2012) Teshome L. Aboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhesus Macaque Theta Defensins Suppress Inflammatory Cytokines and Enhance Survival in Mouse Models of Bacteremic Sepsis

(2012) Justin B. Schaal et al.   PLoS One

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR Spectroscopy

(2011) Leszek Poppe et al.   ANALYTICAL CHEMISTRY

Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

(2011) Thomas A. Knappe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals

(2011) Anne C. Conibear et al.   ISRAEL JOURNAL OF CHEMISTRY

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Investigation of Stability and Disulfide Bond Shuffling of Lipid Transfer Proteins by Molecular Dynamics Simulation

(2010) Jane R. Allison et al.   BIOCHEMISTRY

The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins

(2010) Burkhardt Laufer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities

(2010) Prasad Tongaonkar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Medicinal Chemistry of Peptides

(2009) J. Nestor Jr.   CURRENT MEDICINAL CHEMISTRY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

(2008) Dominik Heckmann et al.   CHEMBIOCHEM

The design, structures and therapeutic potential of protein epitope mimetics

(2008) John A. Robinson et al.   DRUG DISCOVERY TODAY

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides

(2008) Panumart Thongyoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Unfolding the fold of cyclic cysteine-rich peptides

(2008) Amarda Shehu et al.   PROTEIN SCIENCE