Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Disulfide-rich macrocyclic peptides as templates in drug design

(2014) Susan E. Northfield et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polycyclic Peptide Therapeutics

(2013) Vanessa Baeriswyl et al.   ChemMedChem

Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

(2012) Jonathan E. Bock et al.   ACS Chemical Biology

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides

(2011) Oded Ovadia et al.   MOLECULAR PHARMACEUTICS

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MultipleN-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

(2010) Lucas Doedens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

(2009) Conan K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION