Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

(2018) Kelley E. McQueeney et al.   FASEB JOURNAL

Physiological and oncogenic roles of the PRL phosphatases

(2018) Serge Hardy et al.   FEBS Journal

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress

(2018) Jiska van der Reest et al.   Nature Communications

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Tyrosine Phosphatases: Time to End the Stigma

(2017) Stephanie M. Stanford et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3

(2017) Huizhi Zhang et al.   Scientific Reports

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

(2016) Petra den Hollander et al.   CANCER RESEARCH

Phosphocysteine in the PRL‐CNNM pathway mediates magnesium homeostasis

(2016) Irina Gulerez et al.   EMBO REPORTS

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

(2016) Joseph M. Salamoun et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver

(2015) Sven Stadlbauer et al.   PLoS One

Protein Topology Determines Cysteine Oxidation Fate: The Case of Sulfenyl Amide Formation among Protein Families

(2015) Lucas A. Defelipe et al.   PLoS Computational Biology

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

(2014) Birgit Hoeger et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thioredoxin-related Protein 32 (TRP32) Specifically Reduces Oxidized Phosphatase of Regenerating Liver (PRL)

(2013) Tasuku Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of the PRL phosphatases

(2012) Pablo Rios et al.   FEBS Journal

The Metastasis-Promoting Phosphatase PRL-3 Shows Activity toward Phosphoinositides

(2011) Victoria McParland et al.   BIOCHEMISTRY

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects

(2010) John J. Tanner et al.   ANTIOXIDANTS & REDOX SIGNALING

Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2 by Redox Cycling in Reducing Environments

(2010) Karina M. Soares et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents—real hits or promiscuous artifacts?

(2010) Paul A Johnston   CURRENT OPINION IN CHEMICAL BIOLOGY

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

Redox Regulation of the Human Dual Specificity Phosphatase YVH1 through Disulfide Bond Formation

(2009) Christopher A. Bonham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Mass spectrometry study of PRL-3 phosphatase inactivation by disulfide bond formation and cysteine into glycine conversion

(2009) Laura Orsatti et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Development of a 384-Well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents

(2008) Paul A. Johnston et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage

(2008) S. Daouti et al.   CANCER RESEARCH

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

(2008) A. Vogt et al.   MOLECULAR CANCER THERAPEUTICS

The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation

(2008) Shashwati Basak et al.   MOLECULAR CELL