Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

Late-Stage Fluorination: Fancy Novelty or Useful Tool?

(2015) Constanze N. Neumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B

(2015) Kara M. George Rosenker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

(2015) Stuart L. Schreiber et al.   CELL

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles

(2015) Shi Qing Tang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

(2014) Birgit Hoeger et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents

(2014) Elizabeth R Sharlow et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Photochemical Flow Reactions

(2014) Elaine M. Schuster et al.   ISRAEL JOURNAL OF CHEMISTRY

Protein-tyrosine Phosphatase 4A3 (PTP4A3) Promotes Vascular Endothelial Growth Factor Signaling and Enables Endothelial Cell Motility

(2014) Mark W. Zimmerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells

(2013) Garam Min et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Contributions of Academic Laboratories to the Discovery and Development of Chemical Biology Tools

(2013) Donna M. Huryn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural-like Replication of an Unnatural Base Pair for the Expansion of the Genetic Alphabet and Biotechnology Applications

(2013) Lingjun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer

(2013) Mark W. Zimmerman et al.   PLoS One

Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics

(2012) Sofie De Munter et al.   ACS Chemical Biology

PRL-3, An Emerging Marker of Carcinogenesis, Is Strongly Associated with Poor Prognosis

(2012) Katarzyna Guzinska-Ustymowicz et al.   Anti-Cancer Agents in Medicinal Chemistry

The human phosphatase interactome: An intricate family portrait

(2012) Francesca Sacco et al.   FEBS LETTERS

Modular evolution of phosphorylation-based signalling systems

(2012) J. Jin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Conversion of 2,3-dihydroxynaphthazarins to isoquinoline-1,3,4(2H)-trione derivatives

(2012) K. L. Borisova et al.   RUSSIAN CHEMICAL BULLETIN

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors

(2011) Gabriella Gentile et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

(2011) Thomas Mendgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer

(2009) Jian Ming et al.   PATHOLOGY

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage

(2008) S. Daouti et al.   CANCER RESEARCH