Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage

Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

(2018) Omar M. Rahal et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Angiopoietin/Tie2 axis regulates the age-at-injury cerebrovascular response to traumatic brain injury

(2018) Thomas R. Brickler et al.   JOURNAL OF NEUROSCIENCE

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Nonclassical Monocytes Mediate Secondary Injury, Neurocognitive Outcome, and Neutrophil Infiltration after Traumatic Brain Injury

(2017) Hadijat M. Makinde et al.   JOURNAL OF IMMUNOLOGY

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Monitoring the Neuroinflammatory Response Following Acute Brain Injury

(2017) Eric Peter Thelin et al.   Frontiers in Neurology

Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury

(2016) Thomas Brickler et al.   MEDIATORS OF INFLAMMATION

Distinct roles for metalloproteinases during traumatic brain injury

(2016) Si Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Pathophysiology of Traumatic Brain Injury

(2016) Melissa J. McGinn et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death

(2016) Andrew Abboud et al.   Frontiers in Pharmacology

Endothelial-Specific EphA4 Negatively Regulates Native Pial Collateral Formation and Re-Perfusion following Hindlimb Ischemia

(2016) Benjamin Okyere et al.   PLoS One

Targeting the Eph System with Peptides and Peptide Conjugates

(2015) Stefan Riedl et al.   CURRENT DRUG TARGETS

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Differential Activation of Infiltrating Monocyte-Derived Cells After Mild and Severe Traumatic Brain Injury

(2015) Diane M. Trahanas et al.   SHOCK

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

A unique role for p53 in the regulation of M2 macrophage polarization

(2014) L Li et al.   CELL DEATH AND DIFFERENTIATION

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury

(2014) Christine L. Hsieh et al.   JOURNAL OF NEUROTRAUMA

Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype

(2014) Samuel García et al.   PLoS One

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Expression Profiling Reveals Distinct Molecular Signatures Associated With the Rupture of Intracranial Aneurysm

(2014) Hirofumi Nakaoka et al.   STROKE

EphrinB3 blocks EphB3 dependence receptor functions to prevent cell death following traumatic brain injury

(2014) M H Theus et al.   Cell Death & Disease

Traumatic brain injury induces macrophage subsets in the brain

(2013) Christine L. Hsieh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury

(2013) Hanna Algattas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Prospective Evaluation of the Temporal Matrix Metalloproteinase Response after Severe Traumatic Brain Injury in Humans

(2013) Derek J. Roberts et al.   JOURNAL OF NEUROTRAUMA

Association between the Cerebral Inflammatory and Matrix Metalloproteinase Responses after Severe Traumatic Brain Injury in Humans

(2013) Derek J. Roberts et al.   JOURNAL OF NEUROTRAUMA

Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages

(2013) Seung Hyeok Seok et al.   MOLECULES AND CELLS

HDL Induces the Expression of the M2 Macrophage Markers Arginase 1 and Fizz-1 in a STAT6-Dependent Process

(2013) Marie Sanson et al.   PLoS One

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

Interleukin 6 Mediates Neuroinflammation and Motor Coordination Deficits After Mild Traumatic Brain Injury and Brief Hypoxia in Mice

(2013) Sung H. Yang et al.   SHOCK

Biology of Intracranial Aneurysms: Role of Inflammation

(2012) Nohra Chalouhi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression and Activation of EphA4 in the Human Brain After Traumatic Injury

(2012) Tony Frugier et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice

(2012) Anders Hånell et al.   JOURNAL OF NEUROTRAUMA

Eph receptors at synapses: Implications in neurodegenerative diseases

(2011) Yu Chen et al.   CELLULAR SIGNALLING

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

(2011) Seth B. Coffelt et al.   JOURNAL OF IMMUNOLOGY

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

(2010) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of EphA receptors on CD4+ CD45RO+ memory cells stimulates migration

(2010) H. L. Holen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Upregulation of EphA4 on Astrocytes Potentially Mediates Astrocytic Gliosis after Cortical Lesion in the Marmoset Monkey

(2010) Yona Goldshmit et al.   JOURNAL OF NEUROTRAUMA

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data

(2010) Ilya Kupershmidt et al.   PLoS One

Emerging treatments for traumatic brain injury

(2009) Ye Xiong et al.   EXPERT OPINION ON EMERGING DRUGS