Sulfur-containing histidine compounds inhibit γ-glutamyl transpeptidase activity in human cancer cells

Anti-Inflammatory Activity of Marine Ovothiol A in an In Vitro Model of Endothelial Dysfunction Induced by Hyperglycemia

(2018) Immacolata Castellano et al.   Oxidative Medicine and Cellular Longevity

On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential

(2018) Immacolata Castellano et al.   NATURAL PRODUCT REPORTS

In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C–S Lyase and Methyltransferase Reactions

(2018) Nathchar Naowarojna et al.   ORGANIC LETTERS

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis

(2018) YOSUKE SHIMAMURA et al.   ANTICANCER RESEARCH

Antifibrotic Effect of Marine Ovothiol in an In Vivo Model of Liver Fibrosis

(2018) Mariarita Brancaccio et al.   Oxidative Medicine and Cellular Longevity

Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation

(2017) Simon S. Terzyan et al.   PROTEIN SCIENCE

CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia

(2017) Maria Russo et al.   Oncotarget

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

(2016) Akane Kamiyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy

(2016) David A. Gewirtz   CANCER RESEARCH

Short protecting-group-free synthesis of 5-acetylsulfanyl-histidines in water: novel precursors of 5-sulfanyl-histidine and its analogues

(2016) Sylvain Daunay et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Shedding light on ovothiol biosynthesis in marine metazoans

(2016) Immacolata Castellano et al.   Scientific Reports

Human γ-Glutamyl Transpeptidase 1

(2015) Simon S. Terzyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry

(2015) Ellis C. O'Neill et al.   Molecular BioSystems

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Ovothiol Isolated from Sea Urchin Oocytes Induces Autophagy in the Hep-G2 Cell Line

(2014) Gian Russo et al.   Marine Drugs

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma

(2014) Marina Tuzova et al.   Frontiers in Pharmacology

Thiohistidine Biosynthesis

(2013) Florian P. Seebeck   CHIMIA

Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line

(2013) I. Tedesco et al.   FOOD AND CHEMICAL TOXICOLOGY

γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications

(2012) Immacolata Castellano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Preventive Effect of GGsTop, a Novel and Selective  -Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats

(2011) S. Yamamoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification and Characterization of the First Ovothiol Biosynthetic Enzyme

(2011) Andrea Braunshausen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel, Species-specific Class of Uncompetitive Inhibitors of γ-Glutamyl Transpeptidase

(2009) Jarrod B. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells

(2009) Alessandro Corti et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS