Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now

(2017) Nathan C Lo et al.   LANCET INFECTIOUS DISEASES

Miltefosine lipid nanocapsules: Intersection of drug repurposing and nanotechnology for single dose oral treatment of pre-patent schistosomiasis mansoni

(2016) Riham M. El-Moslemany et al.   ACTA TROPICA

Prophylactic effect of artemether on human schistosomiasis mansoni among Egyptian children: A randomized controlled trial

(2016) Hala Elmorshedy et al.   ACTA TROPICA

Discovery of Antischistosomal Drug Leads Based on Tetraazamacrocyclic Derivatives and Their Metal Complexes

(2016) M. O. Faruk Khan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

(2016) Chunkai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Nicholas J Kassebaum et al.   LANCET

Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial

(2016) Remigio M Olveda et al.   LANCET INFECTIOUS DISEASES

Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey

(2016) Stefanie Knopp et al.   Parasites & Vectors

Schistosomiasis vaccines: where do we stand?

(2016) Biniam Mathewos Tebeje et al.   Parasites & Vectors

Antischistosomal activity of artemisinin derivatives in vivo and in patients

(2016) Mohamed E.M. Saeed et al.   PHARMACOLOGICAL RESEARCH

Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best

(2016) Susanne H. Sokolow et al.   PLoS Neglected Tropical Diseases

Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems

(2016) Alessandra Guidi et al.   PLoS Neglected Tropical Diseases

Expanding Praziquantel (PZQ) Access beyond Mass Drug Administration Programs: Paving a Way Forward for a Pediatric PZQ Formulation for Schistosomiasis

(2016) Amaya L. Bustinduy et al.   PLoS Neglected Tropical Diseases

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial

(2016) Beatrice Barda et al.   PLoS Neglected Tropical Diseases

Efficacy of Synriam™, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoni

(2015) Shereen F. Mossallam et al.   ACTA TROPICA

Efficacy and Safety of Arachidonic Acid for Treatment of School-Age Children in Schistosoma mansoni High-Endemicity Regions

(2015) Rashida Barakat et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Activities ofN,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

(2015) Noemi Cowan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni

(2015) Noemi Cowan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Clinical implications of recent findings in schistosome proteomics

(2015) Patrick Driguez et al.   Expert Review of Proteomics

Target-based molecular modeling strategies for schistosomiasis drug discovery

(2015) Leonardo G Ferreira et al.   Future Medicinal Chemistry

Re-positioning protein-kinase inhibitors against schistosomiasis

(2015) Verena Gelmedin et al.   Future Medicinal Chemistry

Natural products with antischistosomal activity

(2015) Josué de Moraes   Future Medicinal Chemistry

Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis

(2015) Ying-Si Lai et al.   LANCET INFECTIOUS DISEASES

Natural Products as Leads in Schistosome Drug Discovery

(2015) Bruno Neves et al.   MOLECULES

Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni

(2015) Noemi Cowan et al.   Parasites & Vectors

Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

(2015) Gordana Panic et al.   PLoS Neglected Tropical Diseases

Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty

(2015) Ernest Tambo et al.   Infectious Diseases of Poverty

Efficacy and Safety of Arachidonic Acid for Treatment of Schistosoma mansoni-Infected Children in Menoufiya, Egypt

(2014) Sahar Selim et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Synthesis and activity of new triphenylphosphonium derivatives of betulin and betulinic acid against Schistosoma mansoni in vitro and in vivo

(2014) Anna Yu. Spivak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Artemisinin Combination Therapies and Malaria Parasite Drug Resistance: The Game Is Afoot

(2014) S. M. Taylor et al.   JOURNAL OF INFECTIOUS DISEASES

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

In vitro and in vivo antischistosomal activity of ferroquine derivatives

(2014) Jennifer Keiser et al.   Parasites & Vectors

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Praziquantel, Mefloquine-Praziquantel, and Mefloquine-Artesunate-Praziquantel against Schistosoma haematobium: A Randomized, Exploratory, Open-Label Trial

(2014) Jennifer Keiser et al.   PLoS Neglected Tropical Diseases

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

(2014) Katrin Ingram-Sieber et al.   PLoS Neglected Tropical Diseases

Repurposing drugs for the treatment and control of helminth infections

(2014) Gordana Panic et al.   International Journal for Parasitology-Drugs and Drug Resistance

Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models

(2013) Ronaldo G.C. Scholte et al.   ACTA TROPICA

Diagnosis and treatment of schistosomiasis in children in the era of intensified control

(2013) Stefanie Knopp et al.   Expert Review of Anti-Infective Therapy

The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment

(2013) Belen Pedrique et al.   Lancet Global Health

Time to set the agenda for schistosomiasis elimination

(2012) David Rollinson et al.   ACTA TROPICA

Antischistosomal Activities of Mefloquine-Related Arylmethanols

(2012) Katrin Ingram et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Schistosomiasis

(2012) Bruno Gryseels   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Medicinal Plants: A Source of Anti-Parasitic Secondary Metabolites

(2012) Michael Wink   MOLECULES

Whole-genome sequence of Schistosoma haematobium

(2012) Neil D Young et al.   NATURE GENETICS

Systematic Review and Meta-Analysis of Artemisinin Based Therapies for the Treatment and Prevention of Schistosomiasis

(2012) Luis Pérez del Villar et al.   PLoS One

In VivoActivity of Aryl Ozonides against Schistosoma Species

(2011) Jennifer Keiser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trioxaquine PA1259 Alkylates Heme in the Blood-Feeding Parasite Schistosoma mansoni

(2011) Vincent Pradines et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemistry and Pharmacology of Neglected Helminthic Diseases

(2011) A. Mullner et al.   CURRENT MEDICINAL CHEMISTRY

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

(2011) Connor O’Brien et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro

(2011) J. Keiser et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effectiveness of a comprehensive schistosomiasis japonica control program in Jiangsu province, China, from 2005 to 2008

(2010) Qing-biao Hong et al.   ACTA TROPICA

From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis

(2010) Jürg Utzinger et al.   ACTA TROPICA

Efficacy and Safety of Mefloquine, Artesunate, Mefloquine‐Artesunate, and Praziquantel againstSchistosoma haematobium: Randomized, Exploratory Open‐Label Trial

(2010) Jennifer Keiser et al.   CLINICAL INFECTIOUS DISEASES

Schistosoma mansoni: Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo

(2010) Theresia Manneck et al.   EXPERIMENTAL PARASITOLOGY

Miltefosine, a promising novel agent for schistosomiasis mansoni

(2010) Maha M. Eissa et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice

(2010) J. Keiser et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ACTs for schistosomiasis: do they act?

(2010) Jürg Utzinger et al.   LANCET INFECTIOUS DISEASES

The position of mefloquine as a 21st century malaria chemoprophylaxis

(2010) Patricia Schlagenhauf et al.   MALARIA JOURNAL

Schistosome genomes: a wealth of information

(2010) Joanne P. Webster et al.   TRENDS IN PARASITOLOGY

In Vitro Activities of Trioxaquines against Schistosoma mansoni

(2009) J. Boissier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

In vitro and in vivo trematode models for chemotherapeutic studies

(2009) J. KEISER   PARASITOLOGY

Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice

(2009) Shu-Hua Xiao et al.   PARASITOLOGY RESEARCH

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

(2009) Sandra D. Melman et al.   PLoS Neglected Tropical Diseases

Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in Mice

(2009) Jennifer Keiser et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice

(2008) Luc Van Nassauw et al.   Travel Medicine and Infectious Disease

Trick or Treat: The Role of Vaccines in Integrated Schistosomiasis Control

(2008) Robert Bergquist et al.   PLoS Neglected Tropical Diseases

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH