Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments

(2017) Kurt R. Brunden et al.   JOURNAL OF ALZHEIMERS DISEASE

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties

(2012) Carlo Ballatore et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Using Intramolecular Disulfide Bonds in Tau Protein to Deduce Structural Features of Aggregation-resistant Conformations

(2012) Sophie Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

“Lest we forget you — methylene blue …”

(2011) R. Heiner Schirmer et al.   NEUROBIOLOGY OF AGING

Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2 by Redox Cycling in Reducing Environments

(2010) Karina M. Soares et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies

(2010) C. Ballatore et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation

(2010) Carlo Ballatore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

(2010) John C O'Leary et al.   Molecular Neurodegeneration

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening

(2009) Alex Crowe et al.   BIOCHEMISTRY

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors

(2009) Kurt R. Brunden et al.   EXPERIMENTAL NEUROLOGY

Structure−Activity Relationship of Cyanine Tau Aggregation Inhibitors

(2009) Edward Chang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Cellular and molecular actions of Methylene Blue in the nervous system

(2009) Murat Oz et al.   MEDICINAL RESEARCH REVIEWS

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

P4-347: Tau aggregation inhibitor (TAI) therapy with rember™ arrests the trajectory of rCBF decline in brain regions affected by Tau pathology in mild and moderate Alzheimer's disease (AD)

(2008) Roger T. Staff et al.   Alzheimers & Dementia

Nucleation-dependent Tau Filament Formation

(2008) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY