Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s Disease

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

(2019) Feng Xiong et al.   Alzheimers & Dementia

Exosome-mimetic nanovesicles contain distinct proteome and post-translational modified protein cargo, in comparison to exosomes

(2019) Amirmohammad Nasiri Kenari et al.   PROTEOMICS

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology

(2019) Wojciech Michno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual strategy for reduced signal suppression effects in MALDI mass spectrometry imaging

(2019) Joakim Bastrup et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

(2018) Maria Luisa Moro et al.   Acta Neuropathologica Communications

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

(2018) Hiroyuki Konishi et al.   Frontiers in Cellular Neuroscience

Post-translational and transcriptional dynamics – regulating  extracellular vesicle biology

(2018) Bethany Claridge et al.   Expert Review of Proteomics

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

(2017) Nobuto Kakuda et al.   Acta Neuropathologica Communications

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology

(2016) Lei Yang et al.   NEUROCHEMICAL RESEARCH

An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

(2016) Luxi Shen et al.   Neuroscience Bulletin

Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

(2016) Sunil S. Adav et al.   Molecular Brain

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

Neutrophil Extracellular Traps in Ulcerative Colitis

(2015) Tue Bjerg Bennike et al.   INFLAMMATORY BOWEL DISEASES

Combined Genome-Wide CSF Aβ-42’s Associations and Simple Network Properties Highlight New Risk Factors for Alzheimer’s Disease

(2015) M. B. R. Souza et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective

(2015) Puneet Talwar et al.   MOLECULAR NEUROBIOLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

(2015) Jae Ho Kim et al.   Scientific Reports

Evaluation of the Effect of Trypsin Digestion Buffers on Artificial Deamidation

(2014) Piliang Hao et al.   JOURNAL OF PROTEOME RESEARCH

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapid and Deep Human Proteome Analysis by Single-dimension Shotgun Proteomics

(2013) Mohammad Pirmoradian et al.   MOLECULAR & CELLULAR PROTEOMICS

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Clusterin in Alzheimer’s disease: a player in the biological behavior of amyloid-beta

(2013) Xiang Li et al.   Neuroscience Bulletin

Amyloid plaque formation precedes dendritic spine loss

(2012) Tobias Bittner et al.   ACTA NEUROPATHOLOGICA

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

(2012) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PeaksPTM: Mass Spectrometry-Based Identification of Peptides with Unspecified Modifications

(2011) Xi Han et al.   JOURNAL OF PROTEOME RESEARCH

Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core

(2011) Christopher P. Sullivan et al.   NEUROSCIENCE LETTERS

Protein Oxidative Modifications During Electrospray Ionization: Solution Phase Electrochemistry or Corona Discharge-Induced Radical Attack?

(2009) Brian L. Boys et al.   ANALYTICAL CHEMISTRY

Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism

(2009) D. Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Characterization of the interaction between Aβ 1–42 and glyceraldehyde phosphodehydrogenase

(2008) Yann Verdier et al.   JOURNAL OF PEPTIDE SCIENCE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease

(2008) Joseph H. Lee et al.   NEUROGENETICS